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LEP — MAT2A

Text-mined interactions from Literome

Chen et al., Gastroenterology 2007 (Colonic Neoplasms...) : Epidermal growth factor, insulin-like growth factor 1, and leptin increased growth and up-regulated MAT2A expression and MAT2A promoter activity in RKO and HT-29 cells
Ramani et al., Hepatology 2008 (Liver Neoplasms) : Leptin 's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta ... Leptin induced the expression of MAT2A and MAT2beta in HepG2 cells and normal human and mouse hepatocytes, but although it increased SAMe level in HepG2 cells, it had no effect on SAMe level in normal hepatocytes ... Increased expression of MAT2A and MAT2beta is required for leptin to be mitogenic, although by entirely different mechanisms ... CONCLUSION : Leptin induces MAT2A and MAT2beta expression in HepG2 cells and normal hepatocytes but is mitogenic only in HepG2 cells
Ramani et al., Hepatology 2010 : Also, MAT2beta regulates leptin signaling