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EGFR — ITGA1

Text-mined interactions from Literome

Yoon et al., Cancer Res 2006 (Breast Neoplasms...) : In summary, we propose a novel mechanism for ErbB2 up-regulation and Ras activation in serum depleted breast cancer cells ; integrin alpha(6)beta ( 4 ) regulates the expression of ErbB2 and the subsequent phosphorylation of EGFR and activation of Ras
Chen et al., Mol Cell Biol 2010 : Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator activated receptor gamma dependent caveolin-1 expression ... Integrin alpha1beta1 negatively regulates the generation of profibrotic reactive oxygen species ( ROS ) by inhibiting epidermal growth factor receptor (EGFR) activation ; however, the mechanism by which it does this is unknown ... In this study, we show that caveolin-1 (Cav-1), a scaffolding protein that binds integrins and controls growth factor receptor signaling, participates in integrin alpha1beta1 mediated EGFR activation ... Thus, integrin alpha1beta1 negatively regulates EGFR activation by positively controlling Cav-1 levels, and the ERK/PPARgamma axis plays a key role in regulating integrin alpha1beta1 dependent Cav-1 expression and consequent EGFR mediated ROS production ... Thus, integrin alpha1beta1 negatively regulates EGFR activation by positively controlling Cav-1 levels, and the ERK/PPARgamma axis plays a key role in regulating integrin alpha1beta1 dependent Cav-1 expression and consequent EGFR mediated ROS production