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MMP9 — NOS1
Text-mined interactions from Literome
Novaro et al., Reprod Fertil Dev 2001
:
In addition, we demonstrated a positive regulatory role of NO on the activity and protein expression of MMP-2 and MMP-9, because NO donors ( NOC-18 and spermine-NONOate ) or the NOS substrate ( L-arginine ) stimulate, whereas
NOS inhibitors ( N ( G ) -nitro-L-arginine methyl ester and N ( G ) -monomethyl-L-arginine )
reduce the expression and gelatinolytic activity of MMP-2 and
MMP-9 in isolated trophoblast cells
Johanning et al., Ann Vasc Surg 2002
(Aortic Aneurysm, Abdominal) :
Nitric oxide synthase (NOS) expression, hemodynamic consequences of NO inhibition, and the
effect of NO on
matrix metalloproteinase ( MMP ) expression during aneurysm formation are unknown
Eagleton et al., J Surg Res 2002
:
This study tested the hypothesis that
nitric oxide synthase (NOS) inhibition in whole aortic wall
causes increases in cytokine stimulated
MMP and TIMP expression ...
NOS inhibition in ex vivo aortic tissue
causes a dose dependent increase in
MMP-9 expression and activity
Robinson et al., Shock 2006
(Endotoxemia) :
Therefore, the purpose of these studies was to compare the
effects of selective and nonselective
NOS inhibition on LPS induced gastric
MMP production
Yang et al., Neurol Res 2007
(Brain Ischemia...) :
In the
presence of a
nitric oxide synthase (NOS) inhibitor, N ( omega ) -nitro-L-arginine methyl ester ( L-NAME ), the expression levels of MMP-2 were decreased, but the expression of
MMP-9 was not decreased by agmatine administration
Pustovrh et al., Reproduction 2007
(Diabetes Mellitus, Experimental) :
In addition, while a NO donor enhanced MMP2 and
MMP9 activities, a
NOS inhibitor
reduced these activities in the maternal side of the placenta from control rats ... On the other hand, the NO donor did not modify MMP2 and MMP9 activities, while the
NOS inhibitor
reduced MMP9 activity in the fetal side of both control and diabetic placentas
Lukivskaya et al., Eur J Clin Invest 2008
(Disease Models, Animal...) :
Both
NOS inhibitors
up-regulated procollagen alpha1 ( I ),
MMP-13 , TIMP-1 and PAI-1 mRNA expression
Chen et al., Tokai J Exp Clin Med 2008
(Plaque, Atherosclerotic) :
Activation of inducible
nitric oxide synthase increases MMP-2 and
MMP-9 levels in ApoE-knockout mice
Moore et al., Gastroenterology 2011
(Disease Models, Animal...) :
Induction of
MMP-9 expression
requires inducible
nitric oxide synthase