◀ Back to JUN

EDN1 — JUN

Pathways - manually collected, often from reviews:

• BioCarta hypoxia-inducible factor in the cardivascular system: HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN) → Endothelin 1 (EDN1) (transcription, activates)
• NCI Pathway Database HIF-1-alpha transcription factor network: AP1 complex (FOS-JUN) → ET1 (EDN1) (transcription, activates) Yamashita et al., J Biol Chem 2001
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database AP-1 transcription factor network: JUN/FOS/GATA2 complex (JUN-FOS-GATA2) → ET1 (EDN1) (transcription, activates) Lee et al., J Biol Chem 1991*, Kawana et al., Mol Cell Biol 1995*
  Evidence: reporter gene, physical interaction

Text-mined interactions from Literome

Vichi et al., J Biol Chem 1999 : Interestingly, the TM7 mutants fell into two classes ; several exhibited greatly decreased AP-1 activity, relative to wild type ETB, whereas others displayed augmented endothelin stimulated AP-1 transcriptional activity relative to wild type ETB
Petkova et al., Int J Parasitol 2001 (Chagas Cardiomyopathy...) : Mitogen activated protein kinases and the transcription factor activator-protein-1 regulate the expression of endothelin-1
Shi-Wen et al., Mol Cell Biol 2006 (Pulmonary Fibrosis) : Constitutive ALK5 independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis : evidence of an autocrine endothelin loop operating through the endothelin A and B receptors
Kawana et al., Mol Cell Biol 1995 : Cooperative interaction of GATA-2 and AP1 regulates transcription of the endothelin-1 gene
Kojima et al., J Vet Med Sci 1997 : In the 5'-upstream region of the EDN1 gene, AP-1 and NF-1 elements were found, suggesting the possibility that the expression of swine EDN1 gene is controlled by protooncogene products Fos and Jun , and TGF-beta
Yamboliev et al., Pulm Pharmacol Ther 1998 : Endothelin-1 activates MAP kinases and c-Jun in pulmonary artery smooth muscle