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IL12A — JUN

Pathways - manually collected, often from reviews:

• KEGG Toll-like receptor signaling pathway: FOS/JUN → IL12A/IL12B (protein-protein, expression)

Text-mined interactions from Literome

Nakahira et al., J Immunol 2002 : An increase in c-Jun, a component of AP-1, in the nuclear compartment was elicited by stimulation with either IL-12 or IL-18, but accumulation of serine phosphorylated c-Jun was induced only by IL-18 capable of activating c-Jun N-terminal kinase
Sugimoto et al., Eur J Immunol 2003 : IL-18, but not IL-12 , induced activator protein-1 (AP-1) responsible for high levels of IFN-gamma promoter activation
Ma et al., J Immunol 2004 : The role of AP-1 in IL-12p40 transcription was confirmed by using antisense c-fos and c-jun oligonucleotides ... Taken together, our results suggest that DXM may inhibit IL-12p40 production in LPS stimulated human monocytic cells by down regulating the activation of JNK MAPK, the AP-1 , and NF-kappaB transcription factors
Park et al., Int Immunol 2004 : IL-12 stimulation greatly enhanced the promoter binding activity of c-Jun/AP-1 , a critical transcription factor for IFN-gamma gene expression in wild-type T cells, but not in STAT4-deficient ( STAT4 ( -/- ) ) T cells ... IL-12 stimulation greatly enhanced the promoter binding activity of c-Jun/AP-1 , a critical transcription factor for IFN-gamma gene expression in wild-type T cells, but not in STAT4-deficient ( STAT4 ( -/- ) ) T cells
Matsumoto et al., J Immunol 2004 (Inflammation) : Concomitantly, simvastatin induces the phosphorylation of c-Jun by the c-Jun N-terminal kinase, resulting in c-Jun dependent activation of the IL-12p40 promoter
Ma et al., J Biol Chem 2009 (Acquired Immunodeficiency Syndrome) : We have previously shown that lipopolysaccharide (LPS) induced IL-12p40 production in monocytic cells is regulated by NFkappaB and AP-1 transcription factors through the activation of two distinct upstream signaling pathways, namely the c-Jun-N-terminal kinase (JNK) and the calmodulin dependent protein kinase-II activated pathways
Wang et al., J Immunol 2012 : ESAT-6 reduced LPS/CD40L stimulated transcription of IL-12p35 and enhanced that of IL-23p19 through inhibition of IFN regulatory factor-1 and upregulation of activating transcription factor-2 and c-Jun , transcriptional regulators of IL-12p35 and IL-23p19, respectively