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ITGA4 — PXN

Pathways - manually collected, often from reviews:

• KEGG Focal adhesion: PXN → Complex of 21 proteins (protein-protein, binding/association)
• NCI Pathway Database Alpha4 beta1 integrin signaling events: None → alpha4/beta1 Integrin/Fibronectin/Paxillin/YWHAZ (dimer) complex (ITGA4-PXN-YWHAZ-ITGB1-FN1) (modification, collaborate)
  Deakin et al., J Cell Sci 2009
  Evidence: mutant phenotype
• NCI Pathway Database Alpha4 beta1 integrin signaling events: CDC42/GDP complex () → alpha4/beta1 Integrin/Fibronectin/Paxillin/YWHAZ (dimer) complex (ITGA4-PXN-YWHAZ-ITGB1-FN1) (modification, collaborate)
  Deakin et al., J Cell Sci 2009
  Evidence: mutant phenotype
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/Fibronectin/Paxillin/YWHAZ (dimer) complex (ITGA4-PXN-YWHAZ-ITGB1-FN1) → None (modification, activates) Deakin et al., J Cell Sci 2009
  Evidence: mutant phenotype
• NCI Pathway Database CXCR4-mediated signaling events: alpha-beta1 Integrin (ITGA8/ITGB1/ITGA10/ITGB1/ITGA6/ITGB1/ITGA1/ITGB1/ITGA3/ITGB1/ITGA2/ITGB1/ITGAV/ITGB1/ITGA11/ITGB1/ITGA4/ITGB1/ITGA7/ITGB1/ITGA5/ITGB1/ITGA9/ITGB1) → FAK/p130 Cas/Paxillin complex (PTK2-BCAR1-PXN) (cell adhesion, collaborate)
  Okabe et al., J Hematother Stem Cell Res 2002, Glodek et al., Leukemia 2007
  Evidence: mutant phenotype, assay
• NCI Pathway Database Alpha4 beta1 integrin signaling events: Type I PKA complex (PRKACA-PRKAR1A-PRKAR1B-PRKACB) → alpha4/beta1 Integrin/Fibronectin/Paxillin complex (PXN-ITGA4-ITGB1-FN1) (modification, activates)
  Liu et al., Nature 1999, Han et al., J Biol Chem 2001, Han et al., J Biol Chem 2003, Nishiya et al., Nat Cell Biol 2005
  Evidence: assay, physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/Fibronectin complex (ITGA4-ITGB1-FN1) → Paxillin (PXN) (modification, collaborate) Liu et al., Nature 1999, Han et al., J Biol Chem 2001, Han et al., J Biol Chem 2003, Nishiya et al., Nat Cell Biol 2005
  Evidence: assay, physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/Fibronectin complex (ITGA4-ITGB1-FN1) → alpha4/beta1 Integrin/Fibronectin/Paxillin complex (PXN-ITGA4-ITGB1-FN1) (modification, collaborate)
  Liu et al., Nature 1999, Han et al., J Biol Chem 2001, Han et al., J Biol Chem 2003, Nishiya et al., Nat Cell Biol 2005
  Evidence: assay, physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: Paxillin (PXN) → alpha4/beta1 Integrin/Fibronectin/Paxillin complex (PXN-ITGA4-ITGB1-FN1) (modification, collaborate)
  Liu et al., Nature 1999, Han et al., J Biol Chem 2001, Han et al., J Biol Chem 2003, Nishiya et al., Nat Cell Biol 2005
  Evidence: assay, physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: Fibronectin/alpha4/beta1 Integrin complex (ITGA4-ITGB1-FN1) → Paxillin (PXN) (modification, collaborate) Liu et al., Nature 1999, Liu et al., J Biol Chem 2000, Hyduk et al., Blood 2004*
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: Fibronectin/alpha4/beta1 Integrin complex (ITGA4-ITGB1-FN1) → alpha4/beta1 Integrin/Fibronectin/Paxillin complex (PXN-ITGA4-ITGB1-FN1) (modification, collaborate)
  Liu et al., Nature 1999, Liu et al., J Biol Chem 2000, Hyduk et al., Blood 2004*
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: Paxillin (PXN) → alpha4/beta1 Integrin/Fibronectin/Paxillin complex (PXN-ITGA4-ITGB1-FN1) (modification, collaborate)
  Liu et al., Nature 1999, Liu et al., J Biol Chem 2000, Hyduk et al., Blood 2004*
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1) → Talin (TLN1) (modification, collaborate) Alon et al., J Cell Biol 2005
  Evidence: mutant phenotype
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1) → alpha4/beta1 Integrin/VCAM1/Paxillin/Talin complex (VCAM1-PXN-TLN1-ITGA4-ITGB1) (modification, collaborate)
  Alon et al., J Cell Biol 2005
  Evidence: mutant phenotype
• NCI Pathway Database Alpha4 beta1 integrin signaling events: Talin (TLN1) → alpha4/beta1 Integrin/VCAM1/Paxillin/Talin complex (VCAM1-PXN-TLN1-ITGA4-ITGB1) (modification, collaborate)
  Alon et al., J Cell Biol 2005
  Evidence: mutant phenotype
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1) → FAK (PTK2) (modification, activates) Rose et al., J Immunol 2003, Nojima et al., Cell Immunol 1995*, Manie et al., Blood 1996
  Evidence: mutant phenotype
• NCI Pathway Database Alpha4 beta1 integrin signaling events: Fibronectin/alpha4/beta1 Integrin complex (ITGA4-ITGB1-FN1) → Paxillin (PXN) (modification, collaborate) Liu et al., Nature 1999, Liu et al., J Biol Chem 2000, Han et al., J Biol Chem 2001, Liu et al., J Biol Chem 2002*, Goldfinger et al., J Cell Biol 2003, Kummer et al., J Biol Chem 2010*
  Evidence: assay
• NCI Pathway Database Alpha4 beta1 integrin signaling events: Fibronectin/alpha4/beta1 Integrin complex (ITGA4-ITGB1-FN1) → alpha4/beta1 Integrin/Fibronectin/Paxillin complex (PXN-FN1) (modification, collaborate)
  Liu et al., Nature 1999, Liu et al., J Biol Chem 2000, Han et al., J Biol Chem 2001, Liu et al., J Biol Chem 2002*, Goldfinger et al., J Cell Biol 2003, Kummer et al., J Biol Chem 2010*
  Evidence: assay
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/Fibronectin complex (ITGA4-ITGB1-FN1) → alpha4/beta1 Integrin/Fibronectin/Paxillin/YWHAZ (dimer) complex (ITGA4-PXN-YWHAZ-ITGB1-FN1) (modification, collaborate)
  Deakin et al., J Cell Sci 2009
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/Fibronectin complex (ITGA4-ITGB1-FN1) → Paxillin (PXN) (modification, collaborate) Deakin et al., J Cell Sci 2009
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/Fibronectin/Paxillin/YWHAZ (dimer) complex (ITGA4-PXN-YWHAZ-ITGB1-FN1) → Paxillin (PXN) (modification, collaborate) Deakin et al., J Cell Sci 2009
  Evidence: physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/Fibronectin/Paxillin/YWHAZ (dimer) complex (ITGA4-PXN-YWHAZ-ITGB1-FN1) → YWHAZ/YWHAZ complex (YWHAZ) (modification, collaborate)
  Deakin et al., J Cell Sci 2009
  Evidence: physical interaction
• NCI Pathway Database a4b7 Integrin signaling: alpha4/beta7 Integrin complex (ITGA4-ITGB7) → Paxillin (PXN) (modification, collaborate) Liu et al., J Biol Chem 2000
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1) → PYK2 (PTK2B) (modification, activates) Kanda et al., Biochem Biophys Res Commun 2003*, Rose et al., J Immunol 2003
  Evidence: mutant phenotype
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1) → Paxillin (PXN) (modification, collaborate) Alon et al., J Cell Biol 2005
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1) → alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1) (modification, collaborate)
  Alon et al., J Cell Biol 2005
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Alpha4 beta1 integrin signaling events: Paxillin (PXN) → alpha4/beta1 Integrin/VCAM1 complex (VCAM1-ITGA4-ITGB1) (modification, collaborate)
  Alon et al., J Cell Biol 2005
  Evidence: mutant phenotype, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: ITGA4 — PXN (affinity chromatography technology) Liu et al., Nature 1999
• IRef Bind_translation Interaction: ITGA4 — PXN (coimmunoprecipitation) Liu et al., Nature 1999
• IRef Biogrid Interaction: ITGA4 — PXN (direct interaction, pull down) Liu et al., J Biol Chem 2002*
• IRef Biogrid Interaction: ITGA4 — PXN (direct interaction, pull down) Han et al., J Biol Chem 2001
• MIPS CORUM ITGA4-PXN-GIT1 complex: ITGA4-PXN-GIT1 complex complex (GIT1-ITGA4-PXN) Nishiya et al., Nat Cell Biol 2005
• IRef Corum Interaction: Complex of GIT1-PXN-ITGA4 (association, affinity chromatography technology) Nishiya et al., Nat Cell Biol 2005
• IRef Dip Interaction: ITGA4 — PXN (physical association, pull down) Ring et al., Proc Natl Acad Sci U S A 2011
• IRef Hprd Interaction: Complex of PXN-ITGA4-PXN-PXN-ITGA4-ITGB1-ITGA4-ITGB1-ITGB1 (in vivo) Pinco et al., Mol Biol Cell 2002*
• IRef Hprd Interaction: ITGA4 — PXN (in vivo) Han et al., J Biol Chem 2001, Liu et al., J Biol Chem 2002*, Rose et al., Immunol Rev 2002*
• IRef Hprd Interaction: ITGA4 — PXN (in vitro) Han et al., J Biol Chem 2001, Liu et al., J Biol Chem 2002*, Rose et al., Immunol Rev 2002*
• IRef Intact Interaction: Complex of 13 proteins (association, anti bait coimmunoprecipitation) Liu et al., Nature 1999
• IRef Intact Interaction: Complex of ITGB1-PXN-ITGA4-VCAM1 (association, cross-linking study) Humphries et al., Science signaling 2009
• IRef Intact Interaction: ITGA4 — PXN (physical association, anti bait coimmunoprecipitation) Liu et al., Nature 1999
• IRef Intact Interaction: ITGA4 — PXN (physical association, affinity chromatography technology) Liu et al., Nature 1999
• IRef Ophid Interaction: ITGA4 — PXN (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Murata et al., Immunol Lett 2002 : Here we demonstrate that ligation of alpha4beta7 integrin with MAdCAM-1 induces a prominent tyrosine phosphorylation of paxillin and a 105-kDa protein (p105) that is reactive with an anti-p130 ( Cas ) antibody, in the mouse T-cell line TK-1
Manevich et al., J Biol Chem 2007 : Talin 1, but not paxillin , was required for VLA-4 to undergo optimal stimulation by the prototypic chemokine, CXCL12, under shear stress conditions
Uhm et al., J Cancer Res Clin Oncol 2010 (Bile Duct Neoplasms...) : Furthermore, phosphorylation of paxillin , cell migration related molecule, was regulated by silencing of integrin alpha4