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IL6 — VIP

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IL6 → VIP (decreases) Burian et al., Peptides 2010*
  Evidence: The known antiinflammatory effects of VIP are in part achieved by the downregulation of several pro-inflammatory cytokines such as interleukin 8 (IL-8), IL-6 and IL-1.

Text-mined interactions from Literome

Delgado et al., J Neuroimmunol 1999 (Endotoxemia) : VIP/PACAP inhibit the production of IL-12, IL-6 , tumor necrosis factor alpha (TNFalpha), and interferon gamma (IFNgamma) in vivo in endotoxemic mice
Delgado et al., J Neuroimmunol 1999 : We reported previously that VIP and PACAP inhibit IL-6 , IL-12, TNF alpha and NO production, and enhance IL-10 production, from lipopolysaccharide (LPS) stimulated macrophages
Delgado et al., J Biol Chem 1999 : We showed previously that VIP and PACAP inhibit the production of macrophage derived tumor necrosis factor-alpha, interleukin (IL)-6 , nitric oxide, and IL-12 ... We showed previously that VIP and PACAP inhibit the production of macrophage derived tumor necrosis factor-alpha, interleukin (IL)-6 , nitric oxide, and IL-12
Park et al., J Dermatol Sci 1999 : The effects of substance P and vasoactive intestinal peptide on interleukin-6 synthesis in cultured human keratinocytes
Brown et al., Mol Cell Neurosci 2000 : Also, VIP enhanced the expression of the high-affinity VIP receptor, increased astrocytic release of interleukin-6 , and indirectly reduced the toxicity of glutamate in neuronal conditioned astrocyte medium
Leceta et al., Ann N Y Acad Sci 2000 (Inflammation) : VIP/PACAP inhibit the production of TNF alpha, IL-6 , IL-12, and nitric oxide ( NO ), and stimulate IL-10 in peritoneal macrophages and Raw 264.7 cells
Delgado et al., J Leukoc Biol 2003 : VIP and PACAP inhibit TNF-alpha, IL-1beta, IL-6 , and NO production by lipopolysaccharide (LPS) activated microglia
Delgado et al., Biochem Biophys Res Commun 2003 : VIP was shown to inhibit IL-6 , TNFalpha, IL-12, chemokine, and nitric oxide production in endotoxin activated macrophages
Hernanz et al., Regul Pept 2003 (Arthritis, Rheumatoid...) : In the present study, we have investigated the in vitro effect of calcitonin related peptide ( CGRP ), neuropeptide Y (NPY), substance P ( SP ) and vasoactive intestinal peptide (VIP) at concentrations of 10 ( -8 ), 10 ( -9 ) and 10 ( -10 ) M on the production of different proinflammatory cytokines or chemokines such as IL-1beta, IL-6 and TNFalpha by peripheral whole blood cells from patients with rheumatoid arthritis, as well as from osteoarthritis patients studied as a control group without immunoinflammatory background
Juarranz et al., Rheumatology (Oxford) 2004 (Arthritis, Rheumatoid...) : The effects of VIP on basal or tumour necrosis factor alpha (TNF-alpha) stimulated production of CCL2 ( MCP-1, monocyte chemotactic protein 1 ), CXCL8 [ interleukin (IL)-8 ], IL-6 and TNF-alpha were studied by specific ELISAs ( enzyme linked immunosorbent assays )
Nagakawa et al., Oncol Rep 2005 (Prostatic Neoplasms) : We performed RT-PCR analysis to assess the expression of VIP receptor ( VPAC1, VPAC2 and PAC1 ) mRNA in normal prostate epithelial and stromal cells and prostate cancer cells, and investigated the effect of VIP and PACAP on the production of IL-6 ... VIP stimulated the production of IL-6 in DU-145/AR prostate cancer and PrEC cells ... VIP stimulated IL-6 promoter transcriptional activity in DU-145/AR cells
Persson et al., Bone 2005 : VIP stimulated IL-6 mRNA expression and protein release in a time- and concentration dependent manner, whereas mRNA expression of the IL-6 receptor, as well as mRNA expressions of IL-11, LIF, OSM and their cognate receptors, were unaffected by VIP
Persson et al., Biochem Biophys Res Commun 2005 : Here, we address the question whether IL-6 production can be affected by interactions between the neuropeptide VIP and proinflammatory, bone resorbing cytokines ... By using calvarial osteoblasts, we showed that IL-1beta increased IL-6 production time- and concentration-dependently, and that these effects were potentiated by VIP ... Furthermore, IL-1beta stimulated IL-6 promoter activity in the osteoblastic cell line MC3T3-E1 stably transfected with a human IL-6 promoter/luciferase construct, and both VIP , and the related neuropeptide PACAP-38, increased the effect of IL-1beta in a synergistic manner
Wang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2007 : VIP could regulate the expression pattern of IL-1, IL-6 , TGF-beta and FasL by Leydig cells, which may contribute to maintain immune privilege of the testis
Juarranz et al., Arthritis Rheum 2008 (Arthritis, Rheumatoid...) : The expression and function of the potential VIP receptors in FLS were studied by RT-PCR, determination of intracellular cAMP production, cell membrane adenylate cyclase ( AC ) activity, and interleukin-6 , CCL2, and CXCL8 production in response to VIP or specific agonists and antagonists
Arranz et al., Mol Immunol 2008 (Arthritis, Rheumatoid...) : As functional consequences, it was observed the VIP induced impaired production of IL-6 and RANTES/CCL5 after LPS stimulation
Nagata et al., J Cell Physiol 2009 : cAMP activation by PACAP/VIP stimulates IL-6 release and inhibits osteoblastic differentiation through VPAC2 receptor in osteoblastic MC3T3 cells ... We also found that PACAP and VIP stimulated IL-6 release, a stimulator of bone resorption, and VPAC2-R silencing inhibited IL-6 production ... Thus, PACAP/VIP can activate adenylate cyclase response and regulate IL-6 release through VPAC2 receptor with profound functional consequences for the inhibition of osteoblastic differentiation in MC3T3-E1 cells
Spangelo et al., Endocrinology 1991 : IL-1 alpha and IL-1 beta ( 10 ng/ml ), vasoactive intestinal peptide ( VIP, 500 nM ), prostaglandin E2 ( PGE2, 1 microM ), and LPS ( 1 ng/ml ) stimulated IL-6 release to a similar degree ... In the presence of VIP and PGE2, IL-1 alpha and IL-1 beta increased IL-6 release without any apparent further change in extracellular or intracellular cAMP
Natsume et al., Int J Mol Med 2010 : In the present study, we investigated the effect of vasoactive intestinal peptide (VIP) on TNF-alpha induced IL-6 synthesis in these cells ... VIP , which by itself slightly stimulated IL-6 synthesis, synergistically enhanced the TNF-alpha induced IL-6 synthesis in MC3T3-E1 cells ... The synergistic effect of VIP on the TNF-alpha induced IL-6 synthesis was concentration dependent in the range between 1 and 70 nM ... PD98059, a specific inhibitor of MEK1/2, significantly suppressed the enhancement of TNF-alpha induced IL-6 synthesis by VIP ... These results strongly suggest that VIP synergistically enhances TNF-alpha stimulated IL-6 synthesis via up-regulating p44/p42 MAP kinase through the adenylyl cyclase-cAMP system in osteoblasts
Spangelo et al., Endocrinology 1990 : Production of interleukin-6 by anterior pituitary cells is stimulated by increased intracellular adenosine 3',5'-monophosphate and vasoactive intestinal peptide ... These data suggest that anterior pituitary cells produce IL-6 in response to increased intracellular cAMP, and that the neuropeptide vasoactive intestinal peptide may act to regulate IL-6 production
Maimone et al., J Neuroimmunol 1993 : Norepinephrine and vasoactive intestinal peptide induce IL-6 secretion by astrocytes : synergism with IL-1 beta and TNF alpha ... NE and VIP promoted IL-6 mRNA synthesis and both substances synergized with interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha) in inducing IL-6 release
Matsumoto et al., Endocrinology 1993 (Pituitary Neoplasms) : PACAP-38, PACAP-27, and VIP all stimulated the release of interleukin-6 (IL-6) from TtT/GF cells ... PACAP-38 and VIP stimulated IL-6 secretion significantly at 10 ( -10 ) -10 ( -9 ) M in a bell shaped manner ; the maximum values were 10 ( -7 ) and 10 ( -8 ) M, respectively
Greenfield et al., J Biol Chem 1996 : In addition, cAMP analogues as well as vasoactive intestinal peptide and isoproterenol, two neuropeptides that stimulate bone resorption by activating cAMP signal transduction in osteoblasts, also induce interleukin-6 and leukemia inhibitory factor in these cells
Lieb et al., J Neuroimmunol 1996 : We demonstrate that the neuropeptides SP, vasoactive intestinal peptide , substance K. cholecytokinine, alpha-endorphin and beta-endorphin are consistently unable to induce the synthesis of IL-1 and IL-6 in human peripheral blood monocytes
Hernanz et al., J Neuroimmunol 1996 : In addition, the production of IL-6 was enhanced by GRP, NPY and VIP in young and old people ... Differential effects of gastrin releasing peptide, neuropeptide Y, somatostatin and vasoactive intestinal peptide on interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha production by whole blood cells from healthy young and old subjects ... In the present study, we have investigated the effect in vitro of gastrin releasing peptide ( GRP, 10 ( -10 ) M ), neuropeptide Y ( NPY, 10 ( -10 ) M ), somatostatin ( 10 ( -10 ) M ) and vasoactive intestinal peptide ( VIP, 10 ( -9 ) M ) on the production of IL-1 beta, IL-6 and TNF alpha by peripheral whole blood cells from healthy young and old people
Cai et al., Endocrinology 1997 : Both forms of PACAP, PACAP-27 and PACAP-38, as well as VIP significantly increased IL-6 production by rat BM-derived stromal cells at physiological concentrations ranging from 10 ( -10 ) -10 ( -8 ) M ... The stimulatory potency of the three related peptides for the production of IL-6, cAMP, and IP3 was almost consistent, suggesting that the dual signaling transduction pathways may be involved in PACAP/VIP induced IL-6 production in rat BM-derived stromal cells ... The results shown in this paper suggest that PACAP/VIP and their receptor play an important role in the IL-6 production and perhaps in the hematopoiesis in the BM
Mullol et al., Neuropeptides 1997 : Vasoactive intestinal peptide (VIP) induces IL-6 and IL-8, but not G-CSF and GM-CSF release from a human bronchial epithelial cell line ... We investigated the effect of VIP on the secretion of IL-6 , IL-8, GM-CSF, and G-CSF from a bronchial epithelial cell line ( BEAS 2B ) ... After 8 h of incubation, VIP increased IL-6 release by 59 % ( P < 0.01 ), causing no effect on IL-8 release ... After 24 h of incubation, VIP increased the release of IL-6 by 48 % ( P < 0.05 ) and IL-8 by 45 % ( P < 0.05 )
Martínez et al., J Leukoc Biol 1998 : We have investigated the effects of VIP and PACAP38 on the production of interleukin-6 (IL-6) , a proinflammatory cytokine, by endotoxin activated murine macrophages ... Whereas VIP and PACAP inhibit with similar dose-response curves the release of IL-6 from macrophages stimulated with a LPS dose range from 100 pg/mL to 10 microg/mL, both neuropeptides enhance IL-6 secretion in unstimulated macrophages and in macrophages stimulated with very low LPS concentrations ( 1-10 pg/mL ) ... VIP and PACAP regulate the production of IL-6 at a transcriptional level
Martinez et al., J Neuroimmunol 1998 : In this study, we investigated the effects of VIP and of the structurally related neuropeptide pituitary adenylate cyclase activating polypeptide ( PACAP38 ) on the production of IL-6 in unstimulated murine peritoneal macrophages ... VIP and PACAP38 regulate the production of IL-6 at a transcriptional level, affecting the de novo synthesis of this cytokine
Delgado et al., J Immunol 1999 : Previous reports showed that VIP/PACAP inhibit IL-6 and TNF-alpha production in LPS stimulated macrophages