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NOS2 — PRNP

Text-mined interactions from Literome

Lu et al., DNA Cell Biol 2012 : In the present study, we examined the activat2ion of nuclear factor-kappa B ( NF-?B ) upon exposure to PrP106-126 and its role in PrP106-126 induced upregulation of inducible nitric oxide synthase (iNOS) and proinflammatory cytokines ( interleukin [ IL]-1ß, tumor necrosis factor [ TNF ] -a, IL-6 ) in Ana-1 macrophages ... The results showed that iNOS and proinflammatory cytokine release was significantly elevated in Ana-1 macrophages upon exposure to PrP106-126 ; that PrP106-126 treatment led to a significant NF-?B activation ; that proinflammatory cytokines gene expression was elevated in macrophages upon exposure to PrP106-126 ; and that NF-?B inhibition significantly abrogated PrP106-126 induced upregulation of iNOS and inflammatory cytokine mRNA expression
Zhang et al., Acta Biochim Biophys Sin (Shanghai) 2013 : PP2 and piceatannol inhibit PrP106-126 induced iNOS activation mediated by CD36 in BV2 microglia