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ANG — SPP1

Text-mined interactions from Literome

Kupfahl et al., Cardiovasc Res 2000 : In the human heart, Ang II does not directly increase collagen or fibronectin mRNA, but it does increase TGFbeta-1 and osteopontin mRNA expression
Yu et al., Kidney Int 2000 (Disease Models, Animal...) : The present study examined whether OPN expression is involved in the progression of renal disease following subtotal ( 5/6 ) nephrectomy ( STNx ) in rats and whether angiotensin II (Ang II) mediates the up-regulation of renal OPN expression and macrophage accumulation in this model by administering valsartan, an Ang II type I (AT1) receptor antagonist, or ramipril, an angiotensin converting enzyme (ACE) inhibitor
Xie et al., J Cell Physiol 2001 : ANG II ( 1 microM, 16 h ) increased osteopontin expression ( fold increase 3.3+/-0.34, n = 12, P < 0.01 ) in CMEC as measured by northern analysis, but not in ARVM
Bruemmer et al., J Clin Invest 2003 (Aortic Aneurysm, Abdominal...) : These data suggest an important role for leukocyte derived OPN in mediating Ang II-accelerated atherosclerosis and aneurysm formation
Abe et al., Hypertens Res 2008 : The goal of the present study was to characterize the signaling mechanisms whereby Ang II increases OPN expression in vascular smooth muscle cells ( VSMC )
Luther et al., Endocrinology 2009 : Ang II did not stimulate osteopontin or TGF-beta expression in the heart or kidney
deBlois et al., Hypertension 1996 (Hypertension) : In vitro, smooth muscle cell expression of osteopontin is associated with cell cycle transit or alterations in cell phenotype, and it is increased by angiotensin II (Ang II) stimulation