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MAPK1 — RPS6KA3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: RPS6KA3 → MAPK1 (increases, MAPK1 Activity, RPS6KA3 Activity)
  Evidence: We further find that the FAP1 site binds ATF1 and CREB from HeLa nuclear extracts and that the phosphorylation of these factors is induced by TPA. ATF1 and CREB can be phosphorylated by Rsk2(RPS6KA3) which is a protein kinase directly activated by Erk (MAPK1) MAP kinases. These results suggest a signaling pathway in which Erk MAP kinase activates the c-fos enhancer by direct phosphorylation of p62TCF and by activation of Rsk related kinases that phosphorylate ATF1 and CREB.
• KEGG Oocyte meiosis: MAPK1/MAPK3 → RPS6KA1/RPS6KA2/RPS6KA3/RPS6KA6 (protein-protein, activation)
  
• KEGG Long-term potentiation: MAPK1/MAPK3 → RPS6KA1/RPS6KA2/RPS6KA3/RPS6KA6 (protein-protein, activation)
  
• KEGG Neurotrophin signaling pathway: MAPK1/MAPK3 → RPS6KA1/RPS6KA2/RPS6KA3/RPS6KA6 (protein-protein, activation)
  
• KEGG Progesterone-mediated oocyte maturation: MAPK1/MAPK3 → RPS6KA1/RPS6KA2/RPS6KA3/RPS6KA6 (protein-protein, activation)
  
• KEGG MAPK signaling pathway: MAPK1/MAPK3 → RPS6KA1/RPS6KA2/RPS6KA3/RPS6KA6 (protein-protein, phosphorylation)
  
• NCI Pathway Database ErbB1 downstream signaling: Erk1-2-active (MAPK3/MAPK1) → RSK2 (RPS6KA3) (modification, activates) Frödin et al., EMBO J 2000*, Roux et al., Mol Cell Biol 2003*, Kang et al., J Biol Chem 2008*
  Evidence: assay, physical interaction
• Reactome Reaction: RPS6KA3 → MAPK1 (reaction) Roux et al., Mol Cell Biol 2003*, Ranganathan et al., Arch Biochem Biophys 2006*
• WikiPathways Insulin Signaling: MINK1/MAP4K4/MAP3K2/MAPK12/MAP3K5/MAPK10/MAP3K3/MAP4K1/MAPK3/MAP2K7/MAPK13/MAP3K1/MAP4K3/MAP2K6/MAP3K8/MAP3K12/MAP2K4/MAPK7/MAPK14/MAP3K11/MAP3K7/MAPK11/MAPK9/MAPK6/MAP3K13/MAP2K3/MAPK4/MAP4K2/MAP2K5/MAP3K10/MAPK1/MAP2K1/MAP3K6/MAP3K4/MAP3K9/MAP4K5/MAP2K2/MAPK8/MAP3K14 → RPS6KA4/RPS6KA3/RPS6KA6/RPS6KA5/RPS6KA1/RPS6KA2 (activation)
  
• WikiPathways Angiopoietin Like Protein 8 Regulatory Pathway: MAP2K1/MAP3K7/MAPK14/MAPK1/MAP2K2/MAP3K2/MAP3K6/MAPK8/MAP4K1/MAP3K11/MAP4K3/MAPK10/MAP2K7/MAP3K4/MAP3K1/MAP3K12/MAPK4/MAPK11/MAP4K5/MAPK6/MAP4K4/MAPK3/MAP3K14/MAPK12/MAP2K5/MAP2K4/MAPK13/MAP3K5/MAPK9/MAPK7/MAP3K3/MAP3K9/MAP3K8/MAP2K6/MAP3K13/MAP4K2/MAP2K3/MAP3K10/MINK1 → RPS6KA5/RPS6KA6/RPS6KA4/RPS6KA1/RPS6KA2/RPS6KA3 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MAPK1 — RPS6KA3 (direct interaction, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Biogrid Interaction: MAPK1 — RPS6KA3 (physical association, affinity chromatography technology) Zhao et al., J Biol Chem 1996*
• IRef Biogrid Interaction: MAPK1 — RPS6KA3 (physical association, affinity chromatography technology) Smith et al., J Biol Chem 1999*
• IRef Hprd Interaction: MAPK1 — RPS6KA3 (in vivo) Roux et al., Mol Cell Biol 2003*, Smith et al., J Biol Chem 1999*
• IRef Innatedb Interaction: MAPK1 — RPS6KA3 (unknown, -) Roux et al., Mol Cell Biol 2003*
• IRef Intact Interaction: MAPK1 — RPS6KA3 (physical association, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Intact Interaction: Complex of 12 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: Complex of MAPK12-PDCD6IP-HMGB1-NAV1-CEP350-RPS6KA2-MAPK3-RPS6KA3-MAPK1 (association, tandem affinity purification) Varjosalo et al., Cell reports 2013
• IRef Ophid Interaction: MAPK1 — RPS6KA3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: MAPK1 — RPS6KA3 (aggregation, confirmational text mining) Roux et al., Mol Cell Biol 2003*