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PTHLH — RUNX2
Text-mined interactions from Literome
Li et al., Exp Cell Res 2004
:
In the present study, we investigated the
effect of
PTHrP on
Runx2 expression in chick upper sternal chondrocytes ( USCs ) ... We further determined the signaling pathways through which
PTHrP regulates
Runx2 transcription ... Our results show that
PTHrP inhibits
Runx2 expression at both the mRNA and protein levels concomitant with a PTHrP mediated suppression of the phenotypic marker of hypertrophy, type X collagen ... We further determined potential signaling pathways through which
PTHrP inhibits
Runx2 expression using protein kinase inhibitors, H89 ( PKA inhibitor ) : Go-6976 ( PKC inhibitor ) : SB203850 ( p38 MAPK inhibitor ), and U0126 ( MEK inhibitor )
van der Horst et al., J Bone Miner Res 2005
:
In addition,
PTHrP and PTH
repressed RunX2 and osx expression ...
PTHrP and PTH
prevented the upregulation of
RunX2 expression associated with osteoblast differentiation in an indirect response
Silvestris et al., Clin Cancer Res 2008
(Multiple Myeloma) :
E4BP4 was specifically induced by
PTHrP and
inhibited both
Runx2 and Osterix, whereas E4BP4 silenced osteoblasts expressed functional levels of both factors
Pratap et al., Cancer Res 2008
(Bone Neoplasms...) :
Furthermore,
Runx2 directly
regulates the TGFbeta induced
PTHrP levels
Wealthall et al., J Cell Physiol 2009
:
In addition, exogenous
PTHrP reduced the expression of genes associated with terminal differentiation : type X collagen,
Runx2 , and ALP, as well as the PTH/PTHrP receptor (PPR)
Zhang et al., J Cell Sci 2009
:
In the present studies, we tested the hypothesis that
PTHrP regulates both
Runx2 and Runx3 protein stability through cyclin D1 ...
PTHrP significantly
suppressed protein levels of both
Runx2 and Runx3 in primary chondrocytes derived from wild-type mice ... By contrast, the suppressive
effect of
PTHrP on
Runx2 and Runx3 protein levels was completely abolished in primary chondrocytes derived from Ccnd1-knockout mice ...
PTHrP suppresses
Runx2 and Runx3 protein levels in chondrocytes through cyclin D1
Kramann et al., Kidney Int 2013
:
Ardura et al. demonstrate a possible link between
PTHrP induced
Runx2 expression and an antiapoptotic effect in tubular epithelial cells