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IL8 — RHOA
Text-mined interactions from Literome
Schmeck et al., Biochem Pharmacol 2006
:
Activation of
RhoA , Rac1 and Cdc42 ( CNF1 ), but not of RhoA alone ( CNF ( Y ) ),
enhanced Listeria dependent
IL-8 release significantly
Perez et al., Am J Physiol Lung Cell Mol Physiol 2007
(Cystic Fibrosis...) :
Continuous inhibition of CFTR-Cl ( - ) conductance for 3-5 days resulted in significant increase in
IL-8 secretion at basal ( P = 0.006 ) and in
response to 10 ( 9 ) Pseudomonas ( P = 0.0001 ), a fourfold decrease in Smad3 expression ( P = 0.02 ), a threefold increase in
RhoA expression, and increased NF-kappaB nuclear translocation upon TNF-alpha/IL-1beta stimulation ( P < 0.000001 )
Petreaca et al., Mol Biol Cell 2007
:
Furthermore, inhibition of the VEGFR abolishes
RhoA activation by
IL-8/CXCL8 , and gap formation, suggesting a mechanism whereby VEGFR2 transactivation mediates IL-8/CXCL8 induced permeability
Liang et al., Zhonghua Yi Xue Za Zhi 2011
(Arthritis, Rheumatoid) :
Inhibition of
RhoA and ROCK with a specific inhibitor
inhibited the secretion of
IL-8 , RANTES and MCP-2 in PG-induced RA FLS