Gene interactions and pathways from curated databases and text-mining

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ACD — CD3E

Text-mined interactions from Literome

Grader-Beck et al., Blood 2003 : Increase of cAMP also inhibited activation of Rap1 mediated by TCR/CD3 plus CD28
Li et al., Blood 2005 : T-cell receptor (TCR)-CD3/CD28 mediated activation of Rap1 and Akt was retained in Tregs, but activation of Ras, mitogenactivated protein kinase 1/2 ( MEK1/2 ), and extracellular signal regulated kinase 1/2 ( Erk1/2 ) was impaired
Hoshi et al., Int Immunol 1994 : The stimulation through TCR-CD3 complexes by immobilized anti-CD3 antibody induced the production of IL-2 and activation induced cell death (ACD) in the majority of T cell hybridomas