Gene interactions and pathways from curated databases and text-mining

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IL2 — RAF1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Maslinski et al., J Biol Chem 1992 : Interleukin-2 (IL-2) induces tyrosine kinase dependent translocation of active raf-1 from the IL-2 receptor into the cytosol
Turner et al., Proc Natl Acad Sci U S A 1991 : Furthermore, much of the IL-2 stimulated phosphorylation of p72-74 Raf-1 occurred on tyrosines
Turner et al., Proc Natl Acad Sci U S A 1993 : Interleukin 2 regulates Raf-1 kinase activity through a tyrosine phosphorylation dependent mechanism in a T-cell line ... These findings provide evidence that the IL-2 stimulated phosphorylation of Raf-1 on tyrosines plays an important role in upregulating the activity of this serine/threonine-specific kinase in CTLL-2 cells and, as such, provides a model system for studying the transfer of growth factor initiated signals from protein tyrosine kinases to serine/threonine-specific kinases
Owaki et al., EMBO J 1993 : Raf-1 is required for T cell IL2 production ... The effects of Raf-1 on interleukin 2 (IL2) production in T cells were examined using activated and inhibitory forms of Raf-1 ... This increase in Raf-1 expression allowed antibodies to CD3 and to CD28 to stimulate IL2 production in the absence of phorbol myristate acetate ( PMA ) and enhanced IL2 production stimulated by these antibodies in the presence of PMA ... We conclude that Raf-1 activity is necessary for IL2 gene transcription and secretion
Whitehurst et al., J Immunol 1996 : Raf-1 activity promotes IL-2 production in activated T lymphocytes ... Expression of constitutively active Raf-1 or MEK1 in Jurkat T cells enhanced the stimulation of IL-2 promoter-driven transcription stimulated by a calcium ionophore and PMA, and together with a calcium ionophore the expression of each protein was sufficient to stimulate NF-AT activity
Barber et al., Blood 1997 : In addition, EPO, IL-2 , and IL-15 activated Raf1 and ERK2, demonstrating that the Raf1/MEK/MAP kinase pathway was activated