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BCL6 — IL21

Text-mined interactions from Literome

Ozaki et al., J Immunol 2004 (Lupus Erythematosus, Systemic) : Moreover, we demonstrate that IL-21 unexpectedly induces expression of both Blimp-1 and Bcl-6 , indicating mechanisms as to how IL-21 can serve as a complex regulator of B cell maturation and terminal differentiation
Tsuruoka et al., Immunol Lett 2007 : IL-21 has a pro-apoptotic effect on freshly isolated B cells stimulated with LPS, and also induces Bcl6 expression in the activated B cells
Nurieva et al., Science 2009 : Bcl6 expression is regulated by interleukin-6 and interleukin-21
Linterman et al., J Exp Med 2010 : IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
Poholek et al., J Immunol 2010 : Bcl6 upregulation and T ( FH ) cell differentiation were independent of IL-6 and IL-21 , revealing that either cytokine is not absolutely required for development of Bcl6 ( + ) T ( FH ) cells in vivo
Eto et al., PloS one 2011 : The combined absence of IL-6 and IL-21 resulted in reduced Tfh differentiation and reduced Bcl6 protein expression
Nakayamada et al., Immunity 2011 : Herein, we showed interleukin-12 acting via the transcription factor STAT4 induced both Il21 and Bcl6 genes, generating cells with features of both Tfh and Th1 cells