Kendrick et al., Gynecol Oncol 2008
(Uterine Cervical Neoplasms) :
IHC revealed an increase in DR5 expression in tumor slices treated with cisplatin for 24 h. IHC and Western blotting demonstrated TRA-8 induced cell death via apoptosis and activation of caspase 3 and 8
Yuan et al., Clin Cancer Res 2013
:
PARP-1 knockdown increased TRA-8 induced activation of caspase-8 in the death induced signaling complex ( DISC )