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CDH1 — HBEGF
Text-mined interactions from Literome
Al Moustafa et al., Lung Cancer 2002
(Carcinoma...) :
In contrast, epidermal growth factor (EGF) or
heparin binding EGF-like growth factor ( HB-EGF )
induces the epithelial-like to fibroblastoid conversion of A549 and H322 cell lines, slightly reduces the expression of
E-cadherin and beta-catenin, but not alpha- and gamma-catenins, and stimulates cell motility
Wang et al., Cancer Res 2007
(Pancreatic Neoplasms) :
Our data here clearly indicated the distinct
role of
pro-HB-EGF in the regulation of
E-cadherin expression and the epithelial-mesenchymal transition ... Expression of noncleaved
pro-HB-EGF in pancreatic cells
resulted in the up-regulation of
E-cadherin through suppression of ZEB1, which is a transcriptional repressor of E-cadherin ... Moreover,
up-regulation of
E-cadherin by
pro-HB-EGF not only resulted in cellular morphologic change but also decreased cell motility and enhanced apoptotic sensitivity in response to gemcitabine-erlotinib treatment
Stoll et al., J Invest Dermatol 2012
:
Immunostaining revealed
HB-EGF induced expression of the mesenchymal protein vimentin and decreased expression of
E-cadherin , as well as nuclear translocation of ß-catenin ... Immunostaining revealed
HB-EGF induced expression of the mesenchymal protein vimentin and decreased expression of
E-cadherin , as well as nuclear translocation of ß-catenin
Su et al., Growth Factors 2013
(Disease Models, Animal...) :
We evaluated the
effect of
HB-EGF on the expression of integrins,
E-cadherin/ß-catenin , and integrin a5ß1 dependent cell-ECM interactions