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CCND1 — PPARG

Text-mined interactions from Literome

Wang et al., Mol Cell Biol 2001 : Herein PPARgamma , liganded by either natural ( 15d-PGJ ( 2 ) and PGD ( 2 ) ) or synthetic ligands ( BRL49653 and troglitazone ), selectively inhibited expression of the cyclin D1 gene
Wang et al., Mol Cell Biol 2003 (Breast Neoplasms...) : PPAR gamma transactivation induced by the ligand BRL49653 was inhibited by cyclin D1 through a pRB- and cdk independent mechanism, requiring a region predicted to form an helix-loop-helix ( HLH ) structure
Sharma et al., J Biol Chem 2004 : Our aim was to elucidate the pathway of PPARgamma2 activation mediated modulation of cyclin D1 transcription in mouse hepatocytes ... Furthermore activation of PPARgamma2 attenuated cyclin D1 promoter activity indicating a transcriptional regulation of cyclin D1 ... Since beta-catenin plays a pivotal role in regulating cyclin D1 transcription, we studied whether PPARgamma2 mediated inhibition of cyclin D1 transcription involved beta-catenin ... Interestingly overexpression of either wild-type or S37A mutant beta-catenin was unable to rescue PPARgamma2 mediated suppression of cyclin D1 transcription, whereas overexpression of cAMP-response element binding protein ( CREB ) was capable of antagonizing this inhibitory effect of PPARgamma2 ... Additionally pretreatment with okadaic acid antagonized PPARgamma2 mediated inhibition of cyclin D1 transcription without any effect on beta-catenin expression ... These results indicated that PPARgamma2 activation inhibited cyclin D1 transcription in hepatocytes via CREB dependent and beta-catenin independent pathways
Sharma et al., J Biol Chem 2004 (Adenomatous Polyposis Coli) : Our earlier studies have shown that troglitazone ( TZD ) -mediated activation of PPARgamma2 in hepatocytes inhibits growth and attenuates cyclin D1 transcription via modulating CREB levels
Huang et al., Mol Pharmacol 2005 (Breast Neoplasms) : We obtain evidence that the ability of high doses of troglitazone and ciglitazone to repress cyclin D1 is independent of PPARgamma activation
Fu et al., J Biol Chem 2005 : In this study, we determined the molecular mechanism by which cyclin D1 regulated PPARgamma function
York et al., Clin Cancer Res 2007 (Carcinoma, Renal Cell...) : PPARgamma is overexpressed in ACHN cells and barely detectable in 786-0 cells, and treatment with DIM-C-pPhtBu induces proteasome dependent degradation of cyclin D1 and variable effects on p21 and p27 expression in both cell lines
Fujisawa et al., J Pharmacol Sci 2008 (Colonic Neoplasms...) : PPARgamma inhibition promoted cell proliferation and increased expressions of the c-myc and cyclin D1 genes and the beta-catenin protein in the colon epithelium
Rageul et al., Int J Cancer 2009 (Colonic Neoplasms) : We also demonstrate that PPARgamma activation leads to increased ( p21WAF1/Cip1 and keratin 19 ) or decreased ( cyclin D1 ) expression of known KLF4 targets, suggesting that KLF4 is a nodal player in a network of PPARgamma regulated genes