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TGFB2 — TMED7

Text-mined interactions from Literome

Taipale et al., Exp Cell Res 2000 : The p27 ( Kip1 ) cyclin dependent kinase inhibitor translocates in response to transforming growth factor-beta to a Cdk2-cyclin E complex inhibiting its catalytic activity, but the p27 ( Kip1 ) protein levels are unaffected [ 1 ] ... We show here that transforming growth factor-beta induces the accumulation of a form of p27 ( Kip1 ) representing a subpopulation of total p27 ( Kip1 ) in growth arrested Mv1Lu epithelial cells
Kim et al., Molecular vision 2001 : Nuclear Cdk4 was absent when the actively cycling cells were treated with TGF-beta2, whereas TGF-beta2 did not induce the expression of nuclear p27 in the same cultures ... TGF-beta2 inhibited phosphorylation of p27 in actively cycling cells, but it had no effect on phosphorylation of p27 in contact inhibited cells ... In these cells, TGF-beta2 downregulated Cdk4 expression and prevented the phosphorylation of p27 , which is a prerequisite for nuclear export of the inhibitor molecule for degradation
Kim et al., Invest Ophthalmol Vis Sci 2001 : When cells were stained for phosphorylated p27 ( Kip1 ), FGF-2 markedly enhanced the staining of phosphorylated p27 ( Kip1 ) in nuclei, whereas both cAMP and TGF-beta2 prevented the phosphorylation of p27 ( Kip1 )
Ciarallo et al., Mol Cell Biol 2002 : Altered p27 ( Kip1 ) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta mediated G ( 1 ) arrest
Joyce et al., Invest Ophthalmol Vis Sci 2002 : Studies were then extended to cultured cells to more directly compare the effects of TGF-beta2 and cell-cell contact on the relative protein and mRNA expression of the CKIs, p27kip1 , and p15INK4b