◀ Back to LEP
LEP — ROCK1
Text-mined interactions from Literome
Zeidan et al., J Pharmacol Exp Ther 2007
(Hypertrophy) :
Our results indicate that the activation of
RhoA/ROCK and PI3K/Akt
plays a pivotal role in
leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics
Moey et al., J Pharmacol Exp Ther 2011
(Cardiomegaly) :
The
stimulation of
RhoA/ROCK by
leptin was associated with significantly increased p115RhoGEF gene and protein expression and exchange activity, all of which were completely prevented by ginseng ... The ability of ginseng to prevent
leptin induced activation of
RhoA/ROCK was further associated with diminished p38 MAPK activation and nuclear translocation
Huang et al., Nat Neurosci 2012
(Obesity) :
Leptin promoted the physical interaction of JAK2 and
ROCK1 , thereby increasing phosphorylation of JAK2 and downstream activation of Stat3 and FOXO1