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AKT2 — IRF6

Text-mined interactions from Literome

Xagorari et al., J Pharmacol Exp Ther 2001 (Inflammation) : Moreover, luteolin inhibited LPS induced phosphorylation of Akt
Klein et al., Cell Signal 2001 (MAP Kinase Signaling System) : LPS , fMLP, and LTB ( 4 ) stimulated similar levels of ERK and Akt activation
Monick et al., J Immunol 2001 : In human alveolar macrophages, we found that LPS activates PI 3-kinase and its downstream effector, Akt ... When we blocked LPS induced ceramide with the inhibitor D609, we blocked LPS induced PI 3-kinase and Akt activation
Zirngibl et al., Mol Cell Biol 2002 : Bone marrow derived Fps/Fes-null macrophages showed no defects in granulocyte-macrophage colony stimulating factor-, interleukin 6 (IL-6)-, or IL-3 induced activation of signal transducer and activator of transcription 3 ( Stat3 ) and Stat5A or LPS induced degradation of I kappa B or activation of p38, Jnk, Erk, or Akt
Xagorari et al., Br J Pharmacol 2002 : 4 : We have previously shown that luteolin blocks Akt phosphorylation in response to LPS in RAW 264.7 macrophages
Bozinovski et al., J Biol Chem 2002 (MAP Kinase Signaling System) : LPS markedly activated Akt and Erk1/2, but not p38, in a GM-CSF dependent manner in direct temporal association with NFkappaB and AP-1 activation
Haller et al., J Biol Chem 2003 (Bacteroides Infections) : The inhibitory effect of TGF-beta1 is mediated independently of B. vulgatus/LPS induced IkappaBalpha, Akt , and RelA phosphorylation as well as NF-kappaB DNA binding activity
Li et al., Infect Immun 2003 : In a stable transfection system, dominant negative mutants of myeloid differentiation factor 88 ( MyD88 ) and interleukin-1 (IL-1) receptor associated kinase 1 ( IRAK-1 ) ( MyD88-TIR and IRAK-DD, respectively ) blocked Akt kinase activity in response to LPS and IL-1 beta
Patel et al., J Surg Res 2004 : Simvastatin suppresses LPS induced Akt phosphorylation in the human monocyte cell line THP-1 ... Therefore, we hypothesized that LPS stimulation would also activate Akt , a downstream effector of Rac, and that this may be blocked by statin pretreatment ... Furthermore, LPS increased Akt activation in THP-1 cells when compared with the nonstimulated controls ... These data demonstrate that LPS stimulation leads to increased Akt phosphorylation, which can be suppressed with simvastatin pretreatment
Kang et al., J Pharmacol Exp Ther 2004 (Cystitis...) : Escherichia coli lipopolysaccharide (LPS) induces an inflammatory response in the bladder and rapidly increases phosphorylation of Akt/protein kinase B ( Akt ), a key enzyme regulating proliferation, apoptosis, and inflammation
Jhun et al., Biochem Biophys Res Commun 2004 : Finally, we observed that AICAR inhibited LPS induced activation of PI 3-kinase and Akt , whereas it had no effect on the activation of p38 and ERK1/2
Kim et al., J Immunol 2004 : TGF-beta1 was further found to decrease LPS induced activation of PI3K and Akt
Schabbauer et al., Arterioscler Thromb Vasc Biol 2004 (Disease Models, Animal...) : We found that wortmannin inhibited LPS induced Akt phosphorylation in blood cells
Connelly et al., J Biol Chem 2005 (Inflammation...) : Furthermore, in human umbilical vein endothelial cells, LPS leads to the activation of eNOS through phosphoinositide 3-kinase- and Akt/protein kinase B-dependent enzyme phosphorylation
Lu et al., J Leukoc Biol 2005 : LY294002 or wortmannin, inhibitors of PI-3K, suppressed LPS induced Akt activity and MMP-9 production
Chagnon et al., Circ Res 2005 (Heart Diseases...) : MIF neutralization also restored the LPS induced deficient nuclear translocation of phospho-Akt and consequently the expression of the heart survival nuclear factor GATA-4
Lee et al., J Pharmacol Exp Ther 2006 : Further analyses revealed that cardamomin did not directly inhibit IkappaB kinases, but it significantly suppressed LPS induced activation of Akt
Lee et al., Neurosci Lett 2006 (Encephalitis...) : Adenosine inhibited LPS induced phosphatidylinositol (PI) 3-kinase activation and Akt phosphorylation, whereas it had no effect on the phosphorylation of p38 and ERK1/2
Li et al., Domest Anim Endocrinol 2007 : AKT/protein kinase B (AKT/PKB) phosphorylation levels at time 0 were not different between GH-treated and control animals ; LPS increased the phosphorylation of AKT/PKB with GH treatment stimulating a four-fold further increase of AKT/PKB phosphorylation
Gutiérrez-Venegas et al., Eur J Pharmacol 2006 : Luteolin pretreatment attenuated LPS induced extracellular signal regulated kinase, p38, and Akt phosphorylation
Pan et al., Biochem Pharmacol 2006 (Cocarcinogenesis...) : We found that acacetin also inhibited LPS induced activation of PI3K/Akt and p44/42, but not p38 MAPK
Jin et al., J Cell Biochem 2007 (Muscular Atrophy) : LPS activated p38 and NF-kappaB, while inhibiting AKT ; whereas, curcumin administration inhibited LPS stimulated p38 activation, without altering the effect of LPS on NF-kappaB and AKT
Liu et al., Mol Immunol 2007 : Further studies show that the triptolide mediated inhibitory effects of LPS induced activation of phosphatidylinositol-3 kinase (PI3-K)/Akt and nuclear NF-kappaB activation are involved in down-regulation of COX-2 and CCR7 expression resulting in impaired migration to secondary lymphoid organs of DC
Miyatake et al., Biochem Biophys Res Commun 2007 : Furthermore, PKC412 suppressed LPS induced Akt and GSK-3beta phosphorylations
Lin et al., Toxicol Appl Pharmacol 2008 : LPS stimulated Src, PYK2, EGFR, and Akt phosphorylation and VCAM-1 expression were attenuated by the inhibitors of Src ( PP1 ), EGFR ( AG1478 ), PI3-K ( LY294002 and wortmannin ), and Akt ( SH-5 ), respectively, or transfection with siRNAs of Src or Akt and shRNA of p110 ... LPS stimulated Akt activation translocated into nucleus and associated with p300 and VCAM-1 promoter region was further confirmed by immunofluorescence, immunoprecipitation, and chromatin immunoprecipitation assays
Tsukamoto et al., J Immunol 2008 : In macrophages from the p110gamma ( -/- ) mouse, LPS induced phosphorylation of Akt occurred normally despite the fact that the action of anaphylatoxin C5a was impaired markedly ... In RAW 264.7 cells expressing short hairpin RNA that targets p110beta, LPS induced phosphorylation of Akt was significantly attenuated
Lee et al., Biochim Biophys Acta 2008 (Neoplasms...) : In addition, IRF-1 directly inhibited the tube formation of endothelial cells on Matrigel and reduced the expression of p-Akt , and p-eNOS, which play a significant role in angiogenesis when stimulated by VEGF
Lee et al., Mol Cells 2008 : In addition, pretreatment with raloxifene reduced LPS induced Akt phosphorylation as well as NF-kappa B DNA binding activity and NF-kappa B-dependent reporter gene activity
Lee et al., Biochem Pharmacol 2008 (Arthritis, Experimental) : This compound also inhibited LPS induced NF-kappaB inducing kinase (NIK) and Akt phosphorylation, which are upstream of NF-kappaB activation
Pan et al., J Agric Food Chem 2008 : We found that pterostilbene also inhibited LPS induced activation of PI3K/Akt , extracellular signal regulated kinase 1/2 and p38 MAPK
Pan et al., Mol Nutr Food Res 2008 : We found that 6-shogaol also inhibited LPS induced activation of PI3K/Akt and extracellular signal regulated kinase 1/2, but not p38 mitogen activated protein kinase ( MAPK )
Ku et al., J Agric Food Chem 2008 : Furthermore, LPS stimulated IKKalpha/beta and Akt phosphorylation was abolished by p38 inhibitor SB203580
Oh et al., Eur J Pharmacol 2008 (Inflammation) : Withaferin A inhibits iNOS expression and nitric oxide production by Akt inactivation and down regulating LPS induced activity of NF-kappaB in RAW 264.7 cells ... However, LPS induced Akt phosphorylation was markedly inhibited by withaferin A, while the phosphorylation of p42/p44 extracellular signal regulated kinases ( ERKs ) was slightly inhibited by withaferin A treatment
Walton et al., Am J Physiol Gastrointest Liver Physiol 2009 : LPS induced rapid phosphorylation of NF-kappaB p65, Akt , and p38 MAPK and degradation of Ikappa-Balpha
Noman et al., Innate Immun 2009 : Thalidomide prevented the activation of nuclear factor (NF)-KB by down regulating phosphorylation of inhibitory KB factor ( IKB ), and IKB kinase (IKK)-alpha and IKK-beta Moreover, thalidomide inhibited LPS induced phosphorylation of AKT , p38 and stress activated protein kinase ( SAPK ) /JNK
Wang et al., Cell Biol Int 2009 : Western blotting showed that 1.0microg/ml LPS enhanced phosphorylation of both Akt at Ser 473 and nuclear factor-kappa B (NF-kappaB) p65 at Ser 536
Peairs et al., Clin Exp Immunol 2009 (Lupus Nephritis) : Mechanistically, AICAR inhibited the LPS/IFN-gamma stimulated PI3K/Akt signalling inflammatory cascade but did not affect LPS/IFN-gamma mediated inhibitory kappa B phosphorylation or nuclear factor (NF)-kappaB ( p65 ) nuclear translocation ... Taken together, these observations suggest that AICAR inhibits LPS/IFN-gamma induced Akt phosphorylation through AMPK activation and may serve as a potential therapeutic target in inflammatory diseases
Kiely et al., J Endocrinol 2009 : Insulin receptor-beta (IR beta) expression levels were increased significantly from 1+/-0.52 to 8.6+/-1.83 units ( P < 0.01 ), whereas calcineurin activity and Akt phosphorylation were significantly ( P < 0.01 and P < 0.05 respectively ) reduced in response to 24 h incubation in the presence of LPS
Oh et al., Neurosci Lett 2009 : We also showed that OA inhibited LPS induced phosphorylation of Akt and p38 MAPK, but not that of ERK
Kuo et al., Mol Nutr Food Res 2009 : Inotilone also inhibited LPS induced activation of PI3K/Akt and extracellular signal regulated kinase 1/2 and p38 mitogen activated protein kinase
Lee et al., J Mol Med (Berl) 2009 (Edema...) : Moreover, the LPS stimulated phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2 and Akt was suppressed by BITC
Lai et al., J Agric Food Chem 2009 : We also found that rosmanol suppressed LPS induced phosphorylation of ERK1/2, p38 mitogen activated protein kinase ( MAPK ) and phosphatidylinositol 3-kinase (PI3K)/Akt signaling
Lee et al., J Immunol 2009 (Atherosclerosis...) : In addition, activation of iPLA(2)beta by LPS caused Akt phosphorylation and was followed by increased Nox1 expression
Sousa et al., J Leukoc Biol 2010 (Inflammation) : LPS resulted in a time dependent activation of Akt , which was blocked by treatment with rolipram or PI3K and Akt inhibitors, and PI3K and Akt inhibitors also enhanced apoptosis and promoted neutrophil clearance
Xuan et al., Cell Physiol Biochem 2010 : Moreover, LPS induced phosphorylation of prosurvival kinases Akt and ERK1/2 was abrogated by thymoquinone
Oh et al., Neurosci Lett 2010 (Inflammation) : We also showed that oleamide inhibited LPS induced phosphorylation of Akt , p38 MAPK, and ERK, activation of PI 3-kinase, and accumulation of reactive oxygen species ( ROS )
Huang et al., J Immunol 2010 : Blockage of LPS induced ERK, JNK, Akt , and NF-kappaB activation contributed to the inhibitory effect of quercetin on DCs
Noman et al., Cell Immunol 2010 (Inflammation) : LPS significantly augmented the expression of RIZ1 and the augmentation was mediated by the activation of nuclear factor (NF)-kappaB and Akt
Munhoz et al., J Neurosci 2010 (Inflammation) : Using electrophoretic mobility shift assay, real-time PCR, and immunoblotting, we investigated the ability of varying concentrations of corticosterone ( CORT, the GC of rats ) to modulate lipopolysaccharide (LPS) induced activation of NF-?B ( nuclear factor ?B ), expression of anti- and proinflammatory factors and of the MAP ( mitogen activated protein ) kinase family [ ERK ( extracellular signal regulated kinase ), p38, and JNK/SAPK ( c-Jun N-terminal protein kinase/stress activated protein kinase ) ], and AKT
Lee et al., PloS one 2010 (Endotoxemia) : Furthermore, in vitro cellular studies demonstrated that LPS ( lipopolysaccharide ) activation of mTORC1-S6K still occurs in the presence of PI3K-Akt inhibition alone, but can be suppressed by concurrent inhibition of PI3K-Akt and MEK-ERK pathways
Hsu et al., Cancer Res 2011 (Colorectal Neoplasms...) : Taken together, the results indicate that stimulation of the TLR4/MD2 complex by LPS activates PI3K/AKT signaling and promotes downstream ß1 integrin function, thereby increasing the adhesiveness and metastatic capacity of CRC cells
Min et al., Int Immunopharmacol 2011 (Inflammation) : Withaferin A had no effect on LPS induced Akt and ERK phosphorylation, but phosphorylation of p38 and JNK was slightly decreased by withaferin A. Withaferin A significantly inhibited LPS induced STAT1 and STAT3 phosphorylation in a dose dependent manner
Yasuda et al., J Pharmacol Sci 2011 : LPS ( 200 ng/ml ) activated Akt and NF-?B, whereas HA ( 1 mg/ml ) down-regulated LPS stimulated phosphorylation of Akt and NF-?B ... Pretreatment with anti-intercellular adhesion molecule-1 ( ICAM-1 ) antibody ( 20 µg/ml ) reversed the inhibitory effects of HA on LPS induced production of IL-6 and activation of Akt and NF-?B
Park et al., Br J Pharmacol 2011 : Moreover, kaempferol inhibited LPS induced NF-?B activation and p38 MAPK, JNK and AKT phosphorylation
Bosmann et al., FASEB J 2011 (Endotoxemia) : In vitro signaling studies indicated that LPS or C5a, or the combination, caused phosphorylation of Akt occurring at threonine 308 but not at serine 473
Min et al., J Pineal Res 2012 : Melatonin markedly inhibited LPS induced Akt phosphorylation and NF-?B activation
Bauerfeld et al., J Immunol 2012 : AKT/PKB is a serine/threonine protein kinase that plays an important role in cell survival, protein synthesis, and controlled inflammation in response to TLRs. Hence we investigated the role of LPS mediated AKT activation in mitochondrial bioenergetics and function in cultured murine macrophages ( B6-MCL ) and bone marrow derived macrophages
Lee et al., Exp Mol Med 2012 (Inflammation) : Interestingly, DK-139 blocked LPS induced Akt phosphorylation
Bordone et al., J Neurochem 2012 (Retinal Degeneration) : Moreover, wortmannin prevented the effect of LPS on p-Akt levels
Arranz et al., Proc Natl Acad Sci U S A 2012 : The microRNA miR-155, whose expression was repressed in naive and in LPS stimulated Akt2 ( -/- ) macrophages, and its target C/EBPß appear to play a key role in this process
Sugiyama et al., Mol Immunol 2012 : Moreover, we revealed that LPS induced phosphorylation of Akt , another key molecule involved in IRF-3 activation, was inhibited by 2-AP
Kim et al., Inflamm Res 2012 : Pretreatment with the PI3K? inhibitor, AS 605240 decreased the LPS induced increase of ROS generation, phosphorylation of Akt , and production of phosphatidyl 3,4,5-trisphosphate in A549 cells
Yang et al., J Mol Med (Berl) 2013 (Endotoxemia...) : LPS caused p38 MAPK-, JNK-, and PI3K/AKT mediated Mcl-1 stabilization and prevented apoptosis, and LPS induced GSK-3ß inactivation mainly through p38 MAPK and PI3K/AKT
Jakus et al., J Nutr Biochem 2013 : Here, we provide the first evidence that resveratrol, by suppressing LPS induced TRAF6 expression and ubiquitination, attenuates the LPS induced TLR4-TRAF6, MAP kinase and Akt pathways that can be significant in its anti-inflammatory effects
Khan et al., J Ethnopharmacol 2013 (Edema...) : The results demonstrated that pretreatment with capillarisin effectively inhibited the LPS induced activation of NF-?B, Akt , and MAP kinase activated inflammatory genes, which is mediated by MyD88 and TIRAP ... The LPS induced activation of p-JNK, p-p38, p-ERK, and p-Akt was significantly inhibited
Schnetzke et al., J Cancer Res Clin Oncol 2013 (Leukemia, Myeloid, Acute) : The E3 ubiquitin ligase TRAF6 inhibits LPS induced AKT activation in FLT3-ITD positive MV4-11 AML cells
Liu et al., Eur J Pharmacol 2013 : Signal transduction studies indicated that DSC significantly inhibited LPS induced phosphorylation of Akt , but not c-Jun N-terminal kinase 1/2, p38, or extracellular signal regulated kinase 1/2
Hyam et al., Eur J Pharmacol 2013 : Arctigenin inhibited LPS induced PI3K, AKT and IKKß phosphorylation, but did not suppress LPS induced IRAK-1 phosphorylation
Jang et al., Int J Mol Med 2013 : In addition, PGS suppressed NF-?B translocation and inhibited the LPS induced phosphorylation of AKT and MAPKs
Liang et al., Arch Pharm Res 2013 : Furthermore, SsnB efficiently suppressed LPS induced phosphorylation of extracellular -signal regulated kinase ( Erk1/2 ) and Akt in HUVECs
Yang et al., Mediators Inflamm 2013 (Acute Lung Injury) : In rat primary alveolar type II ( ATII ) cells, LPS decreased CFTR protein expression via activation of PI3K/Akt, and lipoxin A4 suppressed LPS stimulated phosphorylation of Akt
Yang et al., Food Chem Toxicol 2013 (Disease Models, Animal...) : Furthermore, isorhamnetin inhibited LPS induced JNK and AKT/IKKa/ß phosphorylation
Jeong et al., Biol Pharm Bull 2013 : Ginsenoside Rh1 significantly inhibited LPS/CHX induced Akt phosphorylation, as well as mammalian target of rapamycin and Bcl-2 associated death promoter activation in both cell types