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IRF6 — NEU3
Text-mined interactions from Literome
Gee et al., J Biol Chem 2003
:
Studies conducted to understand the role of MAPKs in the induction of sialidase activity revealed that
LPS induced
sialidase activity was dependent on p42/44 MAPK mediated TNF-alpha production ... Blocking TNF-alpha production by PD98059, a p42/44 inhibitor, significantly reduced the
LPS induced
sialidase activity and CD44-HA binding
Amith et al., Glycoconj J 2009
:
Neuraminidase inhibitors BCX1827, 2-deoxy-2,3-dehydro-N-acetylneuraminic acid ( DANA ), zanamivir and oseltamivir carboxylate have a limited significant inhibition of the
LPS induced
sialidase activity in live BMC-2 macrophage cells but Tamiflu ( oseltamivir phosphate ) completely blocks this activity ... Tamiflu inhibits
LPS induced
sialidase activity in live BMC-2 cells with an IC ( 50 ) of 1.2 microM compared to an IC ( 50 ) of 1015 microM for its hydrolytic metabolite oseltamivir carboxylate ... Tamiflu blockage of
LPS induced Neu1
sialidase activity is not affected in BMC-2 cells pretreated with anticarboxylesterase agent clopidogrel
Finlay et al., Glycoconj J 2010
(Mucolipidoses) :
In contrast, the parent black seed oil ( BSO ) and another constituent of BSO para-cymene ( p-CY ) completely block
LPS induced
sialidase activity