◀ Back to SP1

E2F3 — SP1

Pathways - manually collected, often from reviews:

• FastForward regulation: SP1 → E2F3 (transcriptional regulation, unknown)
  Evidence: DNABINDING
• NCI Pathway Database Direct p53 effectors: E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1) → SP1 (SP1) (transcription, activates) Bist et al., Biochemistry 2000
  Evidence: mutant phenotype, reporter gene, physical interaction
• Reactome Reaction: SP1 → E2F3 (indirect_complex) Parisi et al., Biochem Biophys Res Commun 2002*
• Reactome Reaction: SP1 → E2F3 (reaction) Parisi et al., Biochem Biophys Res Commun 2002*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: SP1 — E2F3 Karlseder et al., Mol Cell Biol 1996
• IRef Bind_translation Interaction: SP1 — E2F3 (unspecified method) Karlseder et al., Mol Cell Biol 1996
• IRef Hprd Interaction: SP1 — E2F3 (in vitro) Karlseder et al., Mol Cell Biol 1996
• IRef Intact Interaction: Complex of 248 proteins (association, pull down) von Eyss et al., EMBO J 2012
• IRef Mppi Interaction: SP1 — E2F3 (copurification) Karlseder et al., Mol Cell Biol 1996
• IRef Ophid Interaction: SP1 — E2F3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Nicolás et al., Biochem J 2003 : Whereas overexpression of NF-Y or E2F had an additive effect on Sp1 overexpression, the activation of Sp1 transcription due to Sp1 was counteracted by Sp3 overexpression
Tapias et al., Cell cycle (Georgetown, Tex.) 2008 : Among the known Sp1 interacting proteins, E2F-DP1 , Cyclin D1, Stat3 and Rb activated the Sp1 promoter, whereas p53 and NF kappaB inhibited it
Hazar-Rethinam et al., J Invest Dermatol 2011 : Transient transfection of E2F1-E2F6 indicated that E2F mediated reduction of Sp1 transcription was not responsible for E2F mediated suppression of squamous differentiation
Shao et al., Oncogene 1995 : Since Rb is a regulator of E2F and Sp1 mediated transcription, we have examined the effect of overexpression of cyclins on transcription mediated by E2F dependent adenovirus E2 promoter and by Sp1 in a cotransfection assay in 3T3 cells