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HDAC1 — NOS3

Text-mined interactions from Literome

Gan et al., J Biol Chem 2005 : Induction of eNOS expression by histone deacetylase (HDAC) inhibitors trichostatin A (TSA) and sodium butyrate was observed in all four different types of non-endothelial cells examined ... Our data suggest that HDAC1 plays a critical role in eNOS repression, and the proximal Sp1 site may serve a key target for HDCA1 mediated eNOS repression in non-endothelial cells
Fish et al., J Biol Chem 2005 : Inhibition of histone deacetylase activity by trichostatin A increased acetylation of histones H3 and H4 at the eNOS proximal promoter in nonexpressing cell types and led to increased steady-state eNOS mRNA transcript levels
Gan et al., Biochem Biophys Res Commun 2006 : Dual effects of histone deacetylase inhibition by trichostatin A on endothelial nitric oxide synthase expression in endothelial cells