Gene interactions and pathways from curated databases and text-mining

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EPHB2 — ITGB3

Text-mined interactions from Literome

Das et al., J Biol Chem 2004 (Breast Neoplasms...) : Furthermore, OPN induces alpha(v)beta(3) integrin/EGFR mediated ERK1/2 phosphorylation and AP-1 activation
Brockbank et al., Br J Cancer 2005 (Carcinoma, Squamous Cell...) : However, integrin beta1 is not required for cell growth or activation of FAK and ERK signalling in vitro or in vivo
Rucci et al., J Cell Sci 2005 (Bone Resorption) : Engagement of alphavbeta3 integrin triggered ERK1/2 phosphorylation, but the underlying molecular mechanism was surprisingly independent of the well known Shc/Ras/Raf-1 cascade, and of phosphorylated MAP/ERK kinase (MEK)1/2, so far the only recognized direct activator of ERK1/2
Pavasant et al., Oral Dis 2008 (MAP Kinase Signaling System) : The anti-alphavbeta3 integrin antibody could also inhibit ERK activation, suggesting the possible role of alphavbeta3 integrin on the regulation of ERK and cell migration
Park et al., Reproductive biology and endocrinology : RB&E 2009 (Endometrial Neoplasms) : Thus, in the present study, we further examined the possibility that GnRH induces integrin beta3 and activation of focal adhesion kinase ( FAK ) through mitogen activated protein kinases ( MAPKs ), ERK1/2 and p38, to inhibit the growth of HEC1A endometrial cancer cell line