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MMP9 — PPARG

Text-mined interactions from Literome

Liu et al., Breast Cancer Res Treat 2003 (Breast Neoplasms...) : Recent data indicate that PPARgamma activation by its ligands can also lead to the inhibition of gelatinase B ( MMP-9 ) and the blockage of migration in macrophages and muscle cells, implying the possibility that PPARgamma ligands may possess anti-invasive activities on tumor cells
Hetzel et al., Thorax 2003 (Bronchitis) : Activation of PPARgamma by rosiglitazone or pioglitazone significantly reduced TNF-alpha and PMA induced MMP-9 gelatinolytic activity in a concentration dependent manner in both cell lines, but did not alter the expression of tissue inhibitor of MMPs type 1 (TIMP-1), the local inhibitor of MMP-9
Worley et al., J Biol Chem 2003 : The synthetic PPAR gamma agonist, GW7845, and the natural agonist 15d-PGJ2, suppressed PMA stimulated MMP-9 in human monocyte-like cells ( THP-1 ) only in the presence of 9-cis-retinoic acid ... Pretreatment of THP-1 cells with the PPAR gamma antagonist, GW9662, suggests that PPAR gamma plays subtly different roles in the regulation of MMP-9 , ADAMTS4 and ADAM28 gene expression
Mix et al., Mol Pharmacol 2004 : Here, we test the hypothesis that CDDO and 15-dPGJ2 use PPAR-gamma to repress MMP gene expression
Liu et al., Cancer Chemother Pharmacol 2005 (Leukemia, Myeloid) : The present study was undertaken to investigate PPAR-gamma ligands induced cell growth inhibition and its influence on matrix metalloproteinase MMP-9 and MMP-2 activities on leukemia K562 and HL-60 cells in vitro
Saika et al., Am J Physiol Cell Physiol 2007 (Burns, Chemical...) : Epithelial cell expression of MMP-2/-9 and TGFbeta1 and its migration were suppressed by PPARgamma overexpression
Ricote et al., Nature 1998 : Here we show that PPAR-gamma is markedly upregulated in activated macrophages and inhibits the expression of the inducible nitric oxide synthase, gelatinase B and scavenger receptor A genes in response to 15d-PGJ2 and synthetic PPAR-gamma ligands
Marx et al., Am J Pathol 1998 (Arteriosclerosis) : Stimulation of PPARgamma with troglitazone or 15-deoxy-delta12,14-prostaglandin J2 in human monocyte derived macrophages inhibited MMP-9 gelatinolytic activity in a concentration dependent fashion as revealed by zymography ... Thus, PPARgamma is present in macrophages in human atherosclerotic lesions and may regulate expression and activity of MMP-9 , an enzyme implicated in plaque rupture