Gene interactions and pathways from curated databases and text-mining

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CDH1 — CTNND1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

van Hengel et al., Proc Natl Acad Sci U S A 1999 (Adenocarcinoma...) : Expression of E-cadherin directed p120(ctn) out of the nucleus ... Moreover, the NES function of endogenously or exogenously expressed p120(ctn) isoforms B was sensitive to the nuclear export inhibitor leptomycin B. Expression of exogenous E-cadherin down-regulated nuclear p120(ctn) whereas activation of protein kinase C increased the level of nuclear p120(ctn)
Davis et al., J Cell Biol 2003 (Cell Transformation, Neoplastic...) : p120-catenin stabilizes epithelial cadherin ( E-cadherin ) in SW48 cells, but the mechanism has not been established
Lee et al., Mol Cells 2005 : Furthermore, Fer binds p120 catenin and has been shown to regulate cadherin function by modulating cadherin-beta-catenin interaction
Nong et al., World J Gastroenterol 2006 (Carcinoma, Hepatocellular...) : We stably overexpressed p120ctn isoform 3A in BEL-7404 human hepatoma cells and studied the effect of p120ctn on beta-catenin and E-cadherin binding as well as p120ctn and beta-catenin subcellular localization using immunoprecipitation, Western blotting and confocal microscopy
Elia et al., Neuron 2006 : In addition, p120 catenin loss resulted in reduced cadherin levels and misregulation of Rho-family GTPases, with decreased Rac1 and increased RhoA activity
Daniel et al., Biochim Biophys Acta 2007 (Neoplasms) : In the past decade, many studies have revealed roles for p120(ctn) in regulating Rho family GTPase activity and E-cadherin stability and turnover, events that occur predominantly at the plasma membrane or in the cytoplasm
Liu et al., Lung Cancer 2009 (Carcinoma, Non-Small-Cell Lung...) : Studies on a variety of cell lines have shown that p120-catenin can directly regulate the stability of E-cadherin complexes and control the activity of small GTPases to influence cell adhesion
Dohn et al., J Cell Biol 2009 : p120-catenin regulates epithelial cadherin stability and has been suggested to function as a tumor suppressor
Reynolds et al., Cell 2010 : p120-catenin regulates cell-cell adhesion by controlling cell surface retention of cadherin
Ardawatia et al., Exp Cell Res 2011 : p120 Catenin ( p120(ctn) ) regulates cadherin stability, and thus facilitates strong cell-cell adhesion
Tikhmyanova et al., PloS one 2011 : We here establish that Cas proteins negatively regulate E-cadherin expression in human mammary cells
Pieters et al., Frontiers in bioscience (Landmark edition) 2012 : Thereby, p120ctn regulates the phosphorylation status and the junctional stability of the cadherin-catenin complex
Yu et al., PloS one 2012 (Adenocarcinoma...) : In the current study, HBE, H460, SPC and LTE cell lines were used to examine the effects of p120ctn isoforms 1A and 3A on E-cadherin expression and cell invasiveness
Hartsock et al., PloS one 2012 : Competitive regulation of E-cadherin juxtamembrane domain degradation by p120-catenin binding and Hakai mediated ubiquitination