◀ Back to CDH1
CDH1 — CTNND1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
CDH1
→
CTNND1
(directlyDecreases, CTNND1 Activity)
Evidence: The homeodomain transcription factors Cdx1 and Cdx2 induce E-cadherin adhesion activity by reducing beta- and p120-catenin tyrosine phosphorylation. We specifically investigated beta- and p120-catenin for tyrosine phosphorylation and found that it was significantly diminished by Cdx1 or Cdx2 expression.
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NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
E-cadherin/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
E-cadherin/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1)
(modification, collaborate)
Anastasiadis et al., Nat Cell Biol 2000
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
E-cadherin/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
RHOA/GDP complex (RHOA)
(modification, collaborate)
Anastasiadis et al., Nat Cell Biol 2000
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
E-cadherin/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
p120 catenin/RhoA/GDP complex (CTNND1-RHOA)
(modification, collaborate)
Anastasiadis et al., Nat Cell Biol 2000
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
E-cadherin/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1)
→
p120 catenin/RhoA/GDP complex (CTNND1-RHOA)
(modification, collaborate)
Anastasiadis et al., Nat Cell Biol 2000
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
Fyn (FYN)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, activates)
Castaño et al., Mol Cell Biol 2007*
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF2/p120 catenin complex (CDH1-CTNND1)
→
p120 catenin (CTNND1)
(modification, collaborate)
Ferber et al., J Biol Chem 2008
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NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF2/p120 catenin complex (CDH1-CTNND1)
→
E-cad-CTF2 (CDH1)
(modification, collaborate)
Ferber et al., J Biol Chem 2008
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
p120 catenin (CTNND1)
→
E-cad-CTF2 (CDH1)
(modification, collaborate)
Ferber et al., J Biol Chem 2008
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
SNX1 (SNX1)
→
E-cadherin/beta catenin/p120 catenin complex (CDH1-CTNNB1-CTNND1)
(translocation, activates)
Bryant et al., J Cell Sci 2007
Evidence: other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
beta catenin (CTNNB1)
→
E-cadherin/Ca2+/p120 catenin complex (CDH1-CTNND1)
(modification, collaborate)
Miravet et al., Mol Cell Biol 2003, Hoschuetzky et al., J Cell Biol 1994, Shibamoto et al., Cell adhesion and communication 1994
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
beta catenin (CTNNB1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Miravet et al., Mol Cell Biol 2003, Hoschuetzky et al., J Cell Biol 1994, Shibamoto et al., Cell adhesion and communication 1994
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/p120 catenin complex (CDH1-CTNND1)
→
alpha catenin (CTNNA1)
(modification, collaborate)
Miravet et al., Mol Cell Biol 2003, Hoschuetzky et al., J Cell Biol 1994, Shibamoto et al., Cell adhesion and communication 1994
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/p120 catenin complex (CDH1-CTNND1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Miravet et al., Mol Cell Biol 2003, Hoschuetzky et al., J Cell Biol 1994, Shibamoto et al., Cell adhesion and communication 1994
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
EGFR/EGFR/EGF/EGF complex (EGFR-EGF)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, activates)
Miravet et al., Mol Cell Biol 2003, Hoschuetzky et al., J Cell Biol 1994, Shibamoto et al., Cell adhesion and communication 1994
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
alpha catenin (CTNNA1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Miravet et al., Mol Cell Biol 2003, Hoschuetzky et al., J Cell Biol 1994, Shibamoto et al., Cell adhesion and communication 1994
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF1/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
E-cad-CTF2/p120 catenin complex (CDH1-CTNND1)
(modification, collaborate)
Marambaud et al., EMBO J 2002, Maretzky et al., Proc Natl Acad Sci U S A 2005, Ferber et al., J Biol Chem 2008, Kiss et al., Mol Biol Cell 2008, Kouchi et al., J Biol Chem 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF1/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
alpha catenin (CTNNA1)
(modification, collaborate)
Marambaud et al., EMBO J 2002, Maretzky et al., Proc Natl Acad Sci U S A 2005, Ferber et al., J Biol Chem 2008, Kiss et al., Mol Biol Cell 2008, Kouchi et al., J Biol Chem 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF1/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
beta catenin-gamma catenin (CTNNB1/JUP)
(modification, collaborate)
Marambaud et al., EMBO J 2002, Maretzky et al., Proc Natl Acad Sci U S A 2005, Ferber et al., J Biol Chem 2008, Kiss et al., Mol Biol Cell 2008, Kouchi et al., J Biol Chem 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF2/p120 catenin complex (CDH1-CTNND1)
→
alpha catenin (CTNNA1)
(modification, collaborate)
Marambaud et al., EMBO J 2002, Maretzky et al., Proc Natl Acad Sci U S A 2005, Ferber et al., J Biol Chem 2008, Kiss et al., Mol Biol Cell 2008, Kouchi et al., J Biol Chem 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF2/p120 catenin complex (CDH1-CTNND1)
→
beta catenin-gamma catenin (CTNNB1/JUP)
(modification, collaborate)
Marambaud et al., EMBO J 2002, Maretzky et al., Proc Natl Acad Sci U S A 2005, Ferber et al., J Biol Chem 2008, Kiss et al., Mol Biol Cell 2008, Kouchi et al., J Biol Chem 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
beta catenin (CTNNB1)
→
E-cadherin/Ca2+/p120 catenin complex (CDH1-CTNND1)
(modification, collaborate)
Meigs et al., Proc Natl Acad Sci U S A 2001
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
beta catenin (CTNNB1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Meigs et al., Proc Natl Acad Sci U S A 2001
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/p120 catenin complex (CDH1-CTNND1)
→
alpha catenin (CTNNA1)
(modification, collaborate)
Meigs et al., Proc Natl Acad Sci U S A 2001
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/p120 catenin complex (CDH1-CTNND1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Meigs et al., Proc Natl Acad Sci U S A 2001
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
alpha catenin (CTNNA1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Meigs et al., Proc Natl Acad Sci U S A 2001
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
G12 family/GTP complex (GNA13_GNA12)
(modification, collaborate)
Meigs et al., Proc Natl Acad Sci U S A 2001
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF2/p120 catenin/Kaiso complex (CDH1-CTNND1-ZBTB33)
→
Kaiso (ZBTB33)
(transcription, activates)
Daniel et al., Nucleic Acids Res 2002*, Ferber et al., J Biol Chem 2008
Evidence: reporter gene, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF2/p120 catenin/Kaiso complex (CDH1-CTNND1-ZBTB33)
→
MMP7 (MMP7)
(transcription, activates)
Daniel et al., Nucleic Acids Res 2002*, Ferber et al., J Biol Chem 2008
Evidence: reporter gene, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
beta catenin (CTNNB1)
→
E-cadherin/Ca2+/p120 catenin complex (CDH1-CTNND1)
(modification, collaborate)
Piedra et al., Mol Cell Biol 2003, Miravet et al., Mol Cell Biol 2003, Hsu et al., Int J Biochem Cell Biol 2009*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
beta catenin (CTNNB1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Piedra et al., Mol Cell Biol 2003, Miravet et al., Mol Cell Biol 2003, Hsu et al., Int J Biochem Cell Biol 2009*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/p120 catenin complex (CDH1-CTNND1)
→
alpha catenin (CTNNA1)
(modification, collaborate)
Piedra et al., Mol Cell Biol 2003, Miravet et al., Mol Cell Biol 2003, Hsu et al., Int J Biochem Cell Biol 2009*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/p120 catenin complex (CDH1-CTNND1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Piedra et al., Mol Cell Biol 2003, Miravet et al., Mol Cell Biol 2003, Hsu et al., Int J Biochem Cell Biol 2009*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
alpha catenin (CTNNA1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Piedra et al., Mol Cell Biol 2003, Miravet et al., Mol Cell Biol 2003, Hsu et al., Int J Biochem Cell Biol 2009*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
None
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Anastasiadis et al., Nat Cell Biol 2000, Yamada et al., J Cell Biol 2007, Braga et al., J Cell Biol 1997
Evidence: assay
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
RHOA/GDP complex (RHOA)
(modification, activates)
Anastasiadis et al., Nat Cell Biol 2000, Yamada et al., J Cell Biol 2007, Braga et al., J Cell Biol 1997
Evidence: assay
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
None
(modification, activates)
Anastasiadis et al., Nat Cell Biol 2000, Yamada et al., J Cell Biol 2007, Braga et al., J Cell Biol 1997
Evidence: assay
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton complex (CDH1-CTNNB1-CTNNA1-CTNND1-LIMA1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN complex (CDH1-CTNNB1-CTNNA1-CTNND1-LIMA1)
(modification, collaborate)
Abe et al., Proc Natl Acad Sci U S A 2008
Evidence: mutant phenotype
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
None
→
E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin complex (CDH1-JUP-CTNNA1-CTNND1)
(modification, collaborate)
Ozawa et al., Proc Natl Acad Sci U S A 1990
Evidence: assay
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
p120 catenin (CTNND1)
→
E-cadherin/gamma catenin/alpha catenin complex (CDH1-JUP-CTNNA1)
(modification, collaborate)
Ozawa et al., Proc Natl Acad Sci U S A 1990
Evidence: assay
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
p120 catenin (CTNND1)
→
E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin complex (CDH1-JUP-CTNNA1-CTNND1)
(modification, collaborate)
Ozawa et al., Proc Natl Acad Sci U S A 1990
Evidence: assay
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
E-cadherin/gamma catenin/alpha catenin complex (CDH1-JUP-CTNNA1)
→
E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin complex (CDH1-JUP-CTNNA1-CTNND1)
(modification, collaborate)
Ozawa et al., Proc Natl Acad Sci U S A 1990
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
beta catenin (CTNNB1)
→
E-cadherin/Ca2+/p120 catenin complex (CDH1-CTNND1)
(modification, collaborate)
Brembeck et al., Genes Dev 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
beta catenin (CTNNB1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Brembeck et al., Genes Dev 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/p120 catenin complex (CDH1-CTNND1)
→
alpha catenin (CTNNA1)
(modification, collaborate)
Brembeck et al., Genes Dev 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/p120 catenin complex (CDH1-CTNND1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Brembeck et al., Genes Dev 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
HGF(dimer)/MET(dimer) complex (MET)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, activates)
Brembeck et al., Genes Dev 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
alpha catenin (CTNNA1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Brembeck et al., Genes Dev 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
Ephrin A1/EPHA2 complex (EFNA1-EPHA2)
(modification, activates)
Zantek et al., Cell Growth Differ 1999, Orsulic et al., J Cell Sci 2000, Miura et al., Mol Biol Cell 2009
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
None
→
E-cad-CTF1/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Noë et al., J Cell Sci 2001, Wheelock et al., J Cell Biochem 1987
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
None
→
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Noë et al., J Cell Sci 2001, Wheelock et al., J Cell Biochem 1987
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF1/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Noë et al., J Cell Sci 2001, Wheelock et al., J Cell Biochem 1987
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF1/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
sE-cad (CDH1)
(modification, collaborate)
Noë et al., J Cell Sci 2001, Wheelock et al., J Cell Biochem 1987
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
MMP3 (MMP3)
(modification, collaborate)
Noë et al., J Cell Sci 2001, Wheelock et al., J Cell Biochem 1987
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
sE-cad (CDH1)
(modification, collaborate)
Noë et al., J Cell Sci 2001, Wheelock et al., J Cell Biochem 1987
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
None
→
E-cad-CTF1/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Noë et al., J Cell Sci 2001, Huguenin et al., PloS one 2008, Lynch et al., Journal of oncology 2010, Wheelock et al., J Cell Biochem 1987
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
None
→
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Noë et al., J Cell Sci 2001, Huguenin et al., PloS one 2008, Lynch et al., Journal of oncology 2010, Wheelock et al., J Cell Biochem 1987
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF1/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Noë et al., J Cell Sci 2001, Huguenin et al., PloS one 2008, Lynch et al., Journal of oncology 2010, Wheelock et al., J Cell Biochem 1987
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF1/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
sE-cad (CDH1)
(modification, collaborate)
Noë et al., J Cell Sci 2001, Huguenin et al., PloS one 2008, Lynch et al., Journal of oncology 2010, Wheelock et al., J Cell Biochem 1987
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
MMP7 (MMP7)
(modification, collaborate)
Noë et al., J Cell Sci 2001, Huguenin et al., PloS one 2008, Lynch et al., Journal of oncology 2010, Wheelock et al., J Cell Biochem 1987
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
sE-cad (CDH1)
(modification, collaborate)
Noë et al., J Cell Sci 2001, Huguenin et al., PloS one 2008, Lynch et al., Journal of oncology 2010, Wheelock et al., J Cell Biochem 1987
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
alpha catenin (CTNNA1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(translocation, collaborate)
Morali et al., Oncogene 2001
Evidence: physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin (CDH1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(translocation, collaborate)
Morali et al., Oncogene 2001
Evidence: physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
beta catenin (CTNNB1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(translocation, collaborate)
Morali et al., Oncogene 2001
Evidence: physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
None
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(translocation, collaborate)
Morali et al., Oncogene 2001
Evidence: physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
IGF-1R heterotetramer/IGF2 complex (IGF2-IGF1R)
(translocation, collaborate)
Morali et al., Oncogene 2001
Evidence: physical interaction
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
E-cadherin/Ca2+/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1)
→
p120 catenin (CTNND1)
(modification, collaborate)
Thoreson et al., J Cell Biol 2000, Ireton et al., J Cell Biol 2002, Hoshino et al., J Biol Chem 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
E-cadherin/Ca2+/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Thoreson et al., J Cell Biol 2000, Ireton et al., J Cell Biol 2002, Hoshino et al., J Biol Chem 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
p120 catenin (CTNND1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Thoreson et al., J Cell Biol 2000, Ireton et al., J Cell Biol 2002, Hoshino et al., J Biol Chem 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
RAP1/GTP/I-afadin complex (MLLT4-RAP1B_RAP1A)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, activates)
Thoreson et al., J Cell Biol 2000, Ireton et al., J Cell Biol 2002, Hoshino et al., J Biol Chem 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database E-cadherin signaling in keratinocytes:
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
formin 1 (FMN1)
(translocation, activates)
Kobielak et al., Nat Cell Biol 2004
Evidence: physical interaction, other species
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
IGF1 (IGF1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Qian et al., EMBO J 2004
Evidence: assay, physical interaction
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
IGF-1R heterotetramer complex (IGF1R)
(modification, inhibits)
Qian et al., EMBO J 2004
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
None
→
E-cadherin/beta catenin/p120 catenin complex (CDH1-CTNNB1-CTNND1)
(translocation, collaborate)
Bryant et al., J Cell Sci 2007
Evidence: mutant phenotype, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
None
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(translocation, collaborate)
Bryant et al., J Cell Sci 2007
Evidence: mutant phenotype, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
alpha catenin (CTNNA1)
→
E-cadherin/beta catenin/p120 catenin complex (CDH1-CTNNB1-CTNND1)
(translocation, collaborate)
Bryant et al., J Cell Sci 2007
Evidence: mutant phenotype, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
alpha catenin (CTNNA1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(translocation, collaborate)
Bryant et al., J Cell Sci 2007
Evidence: mutant phenotype, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/beta catenin/p120 catenin complex (CDH1-CTNNB1-CTNND1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(translocation, collaborate)
Bryant et al., J Cell Sci 2007
Evidence: mutant phenotype, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
RAC1/GTP complex (RAC1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(translocation, activates)
Bryant et al., J Cell Sci 2007
Evidence: mutant phenotype, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
beta catenin (CTNNB1)
→
E-cadherin/Ca2+/p120 catenin complex (CDH1-CTNND1)
(modification, collaborate)
Roura et al., J Biol Chem 1999, Piedra et al., J Biol Chem 2001, Fujita et al., Nat Cell Biol 2002, Duchesne et al., J Biol Chem 2003, Simoneau et al., Cell Signal 2011
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
beta catenin (CTNNB1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Roura et al., J Biol Chem 1999, Piedra et al., J Biol Chem 2001, Fujita et al., Nat Cell Biol 2002, Duchesne et al., J Biol Chem 2003, Simoneau et al., Cell Signal 2011
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/p120 catenin complex (CDH1-CTNND1)
→
alpha catenin (CTNNA1)
(modification, collaborate)
Roura et al., J Biol Chem 1999, Piedra et al., J Biol Chem 2001, Fujita et al., Nat Cell Biol 2002, Duchesne et al., J Biol Chem 2003, Simoneau et al., Cell Signal 2011
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/p120 catenin complex (CDH1-CTNND1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Roura et al., J Biol Chem 1999, Piedra et al., J Biol Chem 2001, Fujita et al., Nat Cell Biol 2002, Duchesne et al., J Biol Chem 2003, Simoneau et al., Cell Signal 2011
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
alpha catenin (CTNNA1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Roura et al., J Biol Chem 1999, Piedra et al., J Biol Chem 2001, Fujita et al., Nat Cell Biol 2002, Duchesne et al., J Biol Chem 2003, Simoneau et al., Cell Signal 2011
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
Src (SRC)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, activates)
Roura et al., J Biol Chem 1999, Piedra et al., J Biol Chem 2001, Fujita et al., Nat Cell Biol 2002, Duchesne et al., J Biol Chem 2003, Simoneau et al., Cell Signal 2011
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
gamma catenin (JUP)
→
E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin complex (CDH1-JUP-CTNNA1-CTNND1)
(modification, collaborate)
Miravet et al., Mol Cell Biol 2003, Shibamoto et al., Cell adhesion and communication 1994
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
alpha catenin (CTNNA1)
→
E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin complex (CDH1-JUP-CTNNA1-CTNND1)
(modification, collaborate)
Miravet et al., Mol Cell Biol 2003, Shibamoto et al., Cell adhesion and communication 1994
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin (CDH1)
→
E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin complex (CDH1-JUP-CTNNA1-CTNND1)
(modification, collaborate)
Miravet et al., Mol Cell Biol 2003, Shibamoto et al., Cell adhesion and communication 1994
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin (CDH1)
→
p120 catenin (CTNND1)
(modification, collaborate)
Miravet et al., Mol Cell Biol 2003, Shibamoto et al., Cell adhesion and communication 1994
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin complex (CDH1-JUP-CTNNA1-CTNND1)
→
Src (SRC)
(modification, collaborate)
Miravet et al., Mol Cell Biol 2003, Shibamoto et al., Cell adhesion and communication 1994
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin complex (CDH1-JUP-CTNNA1-CTNND1)
→
None
(modification, collaborate)
Miravet et al., Mol Cell Biol 2003, Shibamoto et al., Cell adhesion and communication 1994
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin complex (CDH1-JUP-CTNNA1-CTNND1)
→
p120 catenin (CTNND1)
(modification, collaborate)
Miravet et al., Mol Cell Biol 2003, Shibamoto et al., Cell adhesion and communication 1994
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
beta catenin (CTNNB1)
→
E-cadherin/Ca2+/p120 catenin complex (CDH1-CTNND1)
(modification, collaborate)
Gujral et al., Cancer Res 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
beta catenin (CTNNB1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Gujral et al., Cancer Res 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/p120 catenin complex (CDH1-CTNND1)
→
alpha catenin (CTNNA1)
(modification, collaborate)
Gujral et al., Cancer Res 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/p120 catenin complex (CDH1-CTNND1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Gujral et al., Cancer Res 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
alpha catenin (CTNNA1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Gujral et al., Cancer Res 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
RET/GFRalpha1/GDNF complex (GDNF-RET-GFRA1)
(modification, collaborate)
Gujral et al., Cancer Res 2008
Evidence: assay, physical interaction
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
E-cadherin/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
E-cadherin(dimer)/Ca2+ complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Takeda et al., Nat Struct Biol 1999*, Pertz et al., EMBO J 1999*, Klingelhöfer et al., Mol Cell Biol 2002*
Evidence: mutant phenotype, assay
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
E-cadherin/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
None
(modification, collaborate)
Takeda et al., Nat Struct Biol 1999*, Pertz et al., EMBO J 1999*, Klingelhöfer et al., Mol Cell Biol 2002*
Evidence: mutant phenotype, assay
-
NCI Pathway Database E-cadherin signaling in the nascent adherens junction:
E-cadherin(dimer)/Ca2+ complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
None
(modification, collaborate)
Takeda et al., Nat Struct Biol 1999*, Pertz et al., EMBO J 1999*, Klingelhöfer et al., Mol Cell Biol 2002*
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
alpha catenin (CTNNA1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(translocation, collaborate)
Bryant et al., Mol Biol Cell 2005
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/beta catenin complex (CDH1-CTNNB1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(translocation, collaborate)
Bryant et al., Mol Biol Cell 2005
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/beta catenin complex (CDH1-CTNNB1)
→
p120 catenin (CTNND1)
(translocation, collaborate)
Bryant et al., Mol Biol Cell 2005
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
None
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(translocation, collaborate)
Bryant et al., Mol Biol Cell 2005
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
p120 catenin (CTNND1)
(translocation, collaborate)
Bryant et al., Mol Biol Cell 2005
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
FGFR1-FGF complex (/)
(translocation, collaborate)
Bryant et al., Mol Biol Cell 2005
Evidence: assay
-
NCI Pathway Database Arf6 trafficking events:
alpha catenin (CTNNA1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(translocation, collaborate)
Palacios et al., EMBO J 2001, Palacios et al., Nat Cell Biol 2002
Evidence: genetic interaction, mutant phenotype, other species
-
NCI Pathway Database Arf6 trafficking events:
E-cadherin/beta catenin complex (CDH1-CTNNB1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(translocation, collaborate)
Palacios et al., EMBO J 2001, Palacios et al., Nat Cell Biol 2002
Evidence: genetic interaction, mutant phenotype, other species
-
NCI Pathway Database Arf6 trafficking events:
E-cadherin/beta catenin complex (CDH1-CTNNB1)
→
p120 catenin (CTNND1)
(translocation, collaborate)
Palacios et al., EMBO J 2001, Palacios et al., Nat Cell Biol 2002
Evidence: genetic interaction, mutant phenotype, other species
-
NCI Pathway Database Arf6 trafficking events:
None
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(translocation, collaborate)
Palacios et al., EMBO J 2001, Palacios et al., Nat Cell Biol 2002
Evidence: genetic interaction, mutant phenotype, other species
-
NCI Pathway Database Arf6 trafficking events:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
Dynamin 2/GTP complex (DNM2)
(translocation, collaborate)
Palacios et al., EMBO J 2001, Palacios et al., Nat Cell Biol 2002
Evidence: genetic interaction, mutant phenotype, other species
-
NCI Pathway Database Arf6 trafficking events:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
p120 catenin (CTNND1)
(translocation, collaborate)
Palacios et al., EMBO J 2001, Palacios et al., Nat Cell Biol 2002
Evidence: genetic interaction, mutant phenotype, other species
-
NCI Pathway Database E-cadherin signaling in keratinocytes:
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Xie et al., Mol Biol Cell 2005, Xie et al., J Biol Chem 2007
Evidence: assay, physical interaction
-
NCI Pathway Database FGF signaling pathway:
p120ctn (CTNND1)
→
E-cadherin (CDH1)
(translocation, activates)
Bryant et al., Mol Biol Cell 2005
Evidence: assay
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
Vinculin (VCL)
(translocation, activates)
Vasioukhin et al., Cell 2000*, Weiss et al., J Cell Biol 1998*
Evidence: assay, physical interaction
-
NCI Pathway Database E-cadherin signaling in keratinocytes:
E-cadherin/beta catenin-gamma catenin complex (CDH1-CTNNB1_JUP)
→
E-cadherin/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Xie et al., Mol Biol Cell 2005, Calautti et al., J Cell Biol 1998
Evidence: assay, physical interaction, other species
-
NCI Pathway Database E-cadherin signaling in keratinocytes:
E-cadherin/beta catenin-gamma catenin complex (CDH1-CTNNB1_JUP)
→
p120 catenin (CTNND1)
(modification, collaborate)
Xie et al., Mol Biol Cell 2005, Calautti et al., J Cell Biol 1998
Evidence: assay, physical interaction, other species
-
NCI Pathway Database E-cadherin signaling in keratinocytes:
alpha catenin (CTNNA1)
→
E-cadherin/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Xie et al., Mol Biol Cell 2005, Calautti et al., J Cell Biol 1998
Evidence: assay, physical interaction, other species
-
NCI Pathway Database E-cadherin signaling in keratinocytes:
Src (SRC)
→
E-cadherin/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, activates)
Xie et al., Mol Biol Cell 2005, Calautti et al., J Cell Biol 1998
Evidence: assay, physical interaction, other species
-
NCI Pathway Database E-cadherin signaling in keratinocytes:
E-cadherin/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
p120 catenin (CTNND1)
(modification, collaborate)
Xie et al., Mol Biol Cell 2005, Calautti et al., J Cell Biol 1998
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF2/p120 catenin/Kaiso complex (CDH1-CTNND1-ZBTB33)
→
E-cad-CTF2/p120 catenin complex (CDH1-CTNND1)
(modification, collaborate)
Ferber et al., J Biol Chem 2008
Evidence: physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF2/p120 catenin/Kaiso complex (CDH1-CTNND1-ZBTB33)
→
Kaiso (ZBTB33)
(modification, collaborate)
Ferber et al., J Biol Chem 2008
Evidence: physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF2/p120 catenin complex (CDH1-CTNND1)
→
Kaiso (ZBTB33)
(modification, collaborate)
Ferber et al., J Biol Chem 2008
Evidence: physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
None
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Thoreson et al., J Cell Biol 2000, Ireton et al., J Cell Biol 2002, Davis et al., J Cell Biol 2003*, Davis et al., Dev Cell 2006*, Fukumoto et al., Exp Cell Res 2008*
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
p120 catenin (CTNND1)
→
E-cadherin/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1)
(modification, collaborate)
Thoreson et al., J Cell Biol 2000, Ireton et al., J Cell Biol 2002, Davis et al., J Cell Biol 2003*, Davis et al., Dev Cell 2006*, Fukumoto et al., Exp Cell Res 2008*
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
p120 catenin (CTNND1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Thoreson et al., J Cell Biol 2000, Ireton et al., J Cell Biol 2002, Davis et al., J Cell Biol 2003*, Davis et al., Dev Cell 2006*, Fukumoto et al., Exp Cell Res 2008*
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Thoreson et al., J Cell Biol 2000, Ireton et al., J Cell Biol 2002, Davis et al., J Cell Biol 2003*, Davis et al., Dev Cell 2006*, Fukumoto et al., Exp Cell Res 2008*
Evidence: assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF1/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Maretzky et al., Proc Natl Acad Sci U S A 2005, Wild-Bode et al., J Biol Chem 2006, Huguenin et al., PloS one 2008, Dittmer et al., Cell Mol Life Sci 2009, Wheelock et al., J Cell Biochem 1987
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF1/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
None
(modification, collaborate)
Maretzky et al., Proc Natl Acad Sci U S A 2005, Wild-Bode et al., J Biol Chem 2006, Huguenin et al., PloS one 2008, Dittmer et al., Cell Mol Life Sci 2009, Wheelock et al., J Cell Biochem 1987
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF1/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
sE-cad (CDH1)
(modification, collaborate)
Maretzky et al., Proc Natl Acad Sci U S A 2005, Wild-Bode et al., J Biol Chem 2006, Huguenin et al., PloS one 2008, Dittmer et al., Cell Mol Life Sci 2009, Wheelock et al., J Cell Biochem 1987
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
ADAM10 (ADAM10)
→
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, activates)
Maretzky et al., Proc Natl Acad Sci U S A 2005, Wild-Bode et al., J Biol Chem 2006, Huguenin et al., PloS one 2008, Dittmer et al., Cell Mol Life Sci 2009, Wheelock et al., J Cell Biochem 1987
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
None
(modification, collaborate)
Maretzky et al., Proc Natl Acad Sci U S A 2005, Wild-Bode et al., J Biol Chem 2006, Huguenin et al., PloS one 2008, Dittmer et al., Cell Mol Life Sci 2009, Wheelock et al., J Cell Biochem 1987
Evidence: mutant phenotype, assay
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
sE-cad (CDH1)
(modification, collaborate)
Maretzky et al., Proc Natl Acad Sci U S A 2005, Wild-Bode et al., J Biol Chem 2006, Huguenin et al., PloS one 2008, Dittmer et al., Cell Mol Life Sci 2009, Wheelock et al., J Cell Biochem 1987
Evidence: mutant phenotype, assay
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
EPLIN (LIMA1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN complex (CDH1-CTNNB1-CTNNA1-CTNND1-LIMA1)
(modification, collaborate)
Abe et al., Proc Natl Acad Sci U S A 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
EPLIN (LIMA1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Abe et al., Proc Natl Acad Sci U S A 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN complex (CDH1-CTNNB1-CTNNA1-CTNND1-LIMA1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Abe et al., Proc Natl Acad Sci U S A 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF2/p120 catenin complex (CDH1-CTNND1)
→
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Marambaud et al., EMBO J 2002
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF2/p120 catenin complex (CDH1-CTNND1)
→
alpha catenin (CTNNA1)
(modification, collaborate)
Marambaud et al., EMBO J 2002
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-CTF2/p120 catenin complex (CDH1-CTNND1)
→
beta catenin-gamma catenin (CTNNB1/JUP)
(modification, collaborate)
Marambaud et al., EMBO J 2002
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
alpha catenin (CTNNA1)
(modification, collaborate)
Marambaud et al., EMBO J 2002
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
beta catenin-gamma catenin (CTNNB1/JUP)
(modification, collaborate)
Marambaud et al., EMBO J 2002
Evidence: assay, physical interaction
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
EGFR (EGFR)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Qian et al., EMBO J 2004, Hoschuetzky et al., J Cell Biol 1994, Takahashi et al., Exp Cell Res 1996
Evidence: assay, physical interaction
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
EGF (EGF)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Qian et al., EMBO J 2004, Hoschuetzky et al., J Cell Biol 1994, Takahashi et al., Exp Cell Res 1996
Evidence: assay, physical interaction
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
EGFR/EGFR/EGF/EGF complex (EGFR-EGF)
(modification, inhibits)
Qian et al., EMBO J 2004, Hoschuetzky et al., J Cell Biol 1994, Takahashi et al., Exp Cell Res 1996
Evidence: assay, physical interaction
-
NCI Pathway Database E-cadherin signaling in keratinocytes:
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
None
(modification, collaborate)
Calautti et al., J Cell Biol 1998
Evidence: assay, other species
-
NCI Pathway Database E-cadherin signaling in keratinocytes:
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
E-cadherin/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Calautti et al., J Cell Biol 1998
Evidence: assay, other species
-
NCI Pathway Database E-cadherin signaling in keratinocytes:
None
→
E-cadherin/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Calautti et al., J Cell Biol 1998
Evidence: assay, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin/IQGAP1/p120 catenin complex (CDH1-CTNNB1-CTNND1)
→
alpha catenin (CTNNA1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin/IQGAP1/p120 catenin complex (CDH1-CTNNB1-CTNND1)
→
IQGAP1 (IQGAP1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin/IQGAP1/p120 catenin complex (CDH1-CTNNB1-CTNND1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
alpha catenin (CTNNA1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
IQGAP1 (IQGAP1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
RAC1-CDC42/GTP/IQGAP1 complex (RAC1_CDC42-IQGAP1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: physical interaction
-
NCI Pathway Database E-cadherin signaling in keratinocytes:
EGFR (EGFR)
→
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Pece et al., J Biol Chem 2000, Betson et al., J Biol Chem 2002
Evidence: assay, physical interaction
-
NCI Pathway Database E-cadherin signaling in keratinocytes:
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
EGFR(dimer) complex (EGFR)
(modification, activates)
Pece et al., J Biol Chem 2000, Betson et al., J Biol Chem 2002
Evidence: assay, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
alpha catenin (CTNNA1)
→
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Huguenin et al., PloS one 2008
Evidence: assay, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-97kDa EC (CDH1)
→
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Huguenin et al., PloS one 2008
Evidence: assay, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cad-97kDa EC (CDH1)
→
p120 catenin (CTNND1)
(modification, collaborate)
Huguenin et al., PloS one 2008
Evidence: assay, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
beta catenin-gamma catenin (CTNNB1/JUP)
(modification, collaborate)
Huguenin et al., PloS one 2008
Evidence: assay, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
E-cadherin cytoplasmic tail (CDH1)
(modification, collaborate)
Huguenin et al., PloS one 2008
Evidence: assay, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
MEP1B (MEP1B)
(modification, collaborate)
Huguenin et al., PloS one 2008
Evidence: assay, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1)
→
p120 catenin (CTNND1)
(modification, collaborate)
Huguenin et al., PloS one 2008
Evidence: assay, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin cytoplasmic tail (CDH1)
→
p120 catenin (CTNND1)
(modification, collaborate)
Huguenin et al., PloS one 2008
Evidence: assay, other species
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
HGF (HGF)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Qian et al., EMBO J 2004
Evidence: assay
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
MET (MET)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Qian et al., EMBO J 2004
Evidence: assay
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
HGF/MET complex (HGF-MET)
(modification, inhibits)
Qian et al., EMBO J 2004
Evidence: assay
-
NCI Pathway Database FGF signaling pathway:
p120ctn (CTNND1)
→
E-cadherin (CDH1)
(translocation, activates)
Bryant et al., Mol Biol Cell 2005, Sørensen et al., Mol Cell Biol 2008*
Evidence: mutant phenotype, assay
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin complex (PVRL2-MLLT4)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(translocation, activates)
Yeaman et al., J Cell Sci 2004, Nejsum et al., J Cell Biol 2007
Evidence: mutant phenotype, physical interaction
-
Reactome Reaction:
CDH1
→
CTNND1
(direct_complex)
Hülsken et al., J Cell Biol 1994
-
Reactome Reaction:
CDH1
→
CTNND1
(reaction)
Hülsken et al., J Cell Biol 1994
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
CDH1
—
CTNND1
Bonné et al., J Cell Biol 2003*
-
IRef Bind_translation Interaction:
CDH1
—
CTNND1
(two hybrid)
Bonné et al., J Cell Biol 2003*
-
IRef Biogrid Interaction:
CDH1
—
CTNND1
(physical association, affinity chromatography technology)
Hazan et al., J Biol Chem 1998
-
IRef Biogrid Interaction:
CDH1
—
CTNND1
(direct interaction, pull down)
Piedra et al., Mol Cell Biol 2003
-
IRef Biogrid Interaction:
CDH1
—
CTNND1
(direct interaction, two hybrid)
Bonné et al., J Cell Biol 2003*
-
IRef Biogrid Interaction:
CDH1
—
CTNND1
(physical association, affinity chromatography technology)
Piedra et al., Mol Cell Biol 2003
-
IRef Biogrid Interaction:
CDH1
—
CTNND1
(physical association, affinity chromatography technology)
Shibamoto et al., J Cell Biol 1995*
-
IRef Biogrid Interaction:
CDH1
—
CTNND1
(direct interaction, pull down)
Ohkubo et al., J Biol Chem 1999*
-
IRef Biogrid Interaction:
CDH1
—
CTNND1
(physical association, affinity chromatography technology)
Ohkubo et al., J Biol Chem 1999*
-
IRef Biogrid Interaction:
CDH1
—
CTNND1
(direct interaction, two hybrid)
Daniel et al., Mol Cell Biol 1995*
-
IRef Biogrid Interaction:
CDH1
—
CTNND1
(direct interaction, pull down)
Ishiyama et al., Cell 2010*
-
IRef Biogrid Interaction:
CDH1
—
CTNND1
(association, x-ray crystallography)
Ishiyama et al., Cell 2010*
-
IRef Biogrid Interaction:
CDH1
—
CTNND1
(colocalization, imaging technique)
Ishiyama et al., Cell 2010*
-
IRef Biogrid Interaction:
CDH1
—
CTNND1
(physical association, affinity chromatography technology)
Smyth et al., PloS one 2012*
-
IRef Biogrid Interaction:
CDH1
—
CTNND1
(physical association, affinity chromatography technology)
Chen et al., J Cell Biochem 2009*
-
IRef Biogrid Interaction:
CDH1
—
CTNND1
(physical association, affinity chromatography technology)
Del Valle-Pérez et al., J Cell Sci 2011*
-
IRef Biogrid Interaction:
CDH1
—
CTNND1
(physical association, affinity chromatography technology)
Daniel et al., Mol Cell Biol 1995*
-
IRef Biogrid Interaction:
CDH1
—
CTNND1
(physical association, affinity chromatography technology)
Kinch et al., J Cell Biol 1995*
-
IRef Biogrid Interaction:
CDH1
—
CTNND1
(physical association, affinity chromatography technology)
Ireton et al., J Cell Biol 2002
-
IRef Hprd Interaction:
CTNND1
—
CDH1
(in vivo)
Aono et al., J Cell Biol 1999*, Ohkubo et al., J Biol Chem 1999*, Thoreson et al., J Cell Biol 2000, Wijnhoven et al., Br J Surg 2000*, Baki et al., Proc Natl Acad Sci U S A 2001*, Kinch et al., J Cell Biol 1995*, Daniel et al., Mol Cell Biol 1995*
-
IRef Hprd Interaction:
CTNND1
—
CDH1
(in vitro)
Aono et al., J Cell Biol 1999*, Ohkubo et al., J Biol Chem 1999*, Thoreson et al., J Cell Biol 2000, Wijnhoven et al., Br J Surg 2000*, Baki et al., Proc Natl Acad Sci U S A 2001*, Kinch et al., J Cell Biol 1995*, Daniel et al., Mol Cell Biol 1995*
-
IRef Hprd Interaction:
CTNND1
—
CDH1
(two hybrid)
Aono et al., J Cell Biol 1999*, Ohkubo et al., J Biol Chem 1999*, Thoreson et al., J Cell Biol 2000, Wijnhoven et al., Br J Surg 2000*, Baki et al., Proc Natl Acad Sci U S A 2001*, Kinch et al., J Cell Biol 1995*, Daniel et al., Mol Cell Biol 1995*
-
IRef Innatedb Interaction:
CTNND1
—
CDH1
(unknown, -)
Ling et al., J Cell Biol 2007*
-
IRef Innatedb Interaction:
CTNND1
—
CDH1
(unknown, -)
Reynolds et al., Exp Cell Res 1996*
-
IRef Intact Interaction:
Complex of YAP1-IQGAP1-CDH1-CTNNA1-CTNND1-CTNNA2-CDH3-CTNNB1
(association, anti bait coimmunoprecipitation)
Schlegelmilch et al., Cell 2011
-
IRef Intact Interaction:
Complex of CDH1-CTNND1-FRMD5
(association, anti bait coimmunoprecipitation)
Wang et al., FEBS Lett 2012*
-
IRef Intact Interaction:
Complex of 59 proteins
(association, tandem affinity purification)
Li et al., Molecular systems biology 2013
-
IRef Intact Interaction:
Complex of 24 proteins
(association, tandem affinity purification)
Li et al., Molecular systems biology 2013
-
IRef Intact Interaction:
Complex of PLEKHA7-CDH1-CTNND1
(physical association, anti tag coimmunoprecipitation)
Meng et al., Cell 2008*
-
IRef Intact Interaction:
CDH1
—
CTNND1
(direct interaction, x-ray crystallography)
Ishiyama et al., Cell 2010*
-
IRef Intact Interaction:
CDH1
—
CTNND1
(colocalization, fluorescence microscopy)
Ishiyama et al., Cell 2010*
Text-mined interactions from Literome
van Hengel et al., Proc Natl Acad Sci U S A 1999
(Adenocarcinoma...) :
Expression of
E-cadherin directed
p120(ctn) out of the nucleus ... Moreover, the NES function of endogenously or exogenously expressed p120(ctn) isoforms B was sensitive to the nuclear export inhibitor leptomycin B. Expression of exogenous
E-cadherin down-regulated nuclear
p120(ctn) whereas activation of protein kinase C increased the level of nuclear p120(ctn)
Davis et al., J Cell Biol 2003
(Cell Transformation, Neoplastic...) :
p120-catenin stabilizes
epithelial cadherin ( E-cadherin ) in SW48 cells, but the mechanism has not been established
Lee et al., Mol Cells 2005
:
Furthermore, Fer binds
p120 catenin and has been shown to
regulate cadherin function by modulating
cadherin-beta-catenin interaction
Nong et al., World J Gastroenterol 2006
(Carcinoma, Hepatocellular...) :
We stably overexpressed p120ctn isoform 3A in BEL-7404 human hepatoma cells and studied the
effect of
p120ctn on beta-catenin and
E-cadherin binding as well as p120ctn and beta-catenin subcellular localization using immunoprecipitation, Western blotting and confocal microscopy
Elia et al., Neuron 2006
:
In addition,
p120 catenin loss
resulted in reduced
cadherin levels and misregulation of Rho-family GTPases, with decreased Rac1 and increased RhoA activity
Daniel et al., Biochim Biophys Acta 2007
(Neoplasms) :
In the past decade, many studies have revealed
roles for
p120(ctn) in regulating Rho family GTPase activity and
E-cadherin stability and turnover, events that occur predominantly at the plasma membrane or in the cytoplasm
Liu et al., Lung Cancer 2009
(Carcinoma, Non-Small-Cell Lung...) :
Studies on a variety of cell lines have shown that
p120-catenin can directly
regulate the stability of
E-cadherin complexes and control the activity of small GTPases to influence cell adhesion
Dohn et al., J Cell Biol 2009
:
p120-catenin regulates
epithelial cadherin stability and has been suggested to function as a tumor suppressor
Reynolds et al., Cell 2010
:
p120-catenin regulates cell-cell adhesion by controlling cell surface retention of
cadherin
Ardawatia et al., Exp Cell Res 2011
:
p120 Catenin ( p120(ctn) )
regulates cadherin stability, and thus facilitates strong cell-cell adhesion
Tikhmyanova et al., PloS one 2011
:
We here establish that
Cas proteins negatively
regulate E-cadherin expression in human mammary cells
Pieters et al., Frontiers in bioscience (Landmark edition) 2012
:
Thereby,
p120ctn regulates the phosphorylation status and the junctional stability of the
cadherin-catenin complex
Yu et al., PloS one 2012
(Adenocarcinoma...) :
In the current study, HBE, H460, SPC and LTE cell lines were used to examine the
effects of
p120ctn isoforms 1A and 3A on
E-cadherin expression and cell invasiveness
Hartsock et al., PloS one 2012
:
Competitive
regulation of
E-cadherin juxtamembrane domain degradation by
p120-catenin binding and Hakai mediated ubiquitination