Gene interactions and pathways from curated databases and text-mining

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CXCR1 — IRF6

Text-mined interactions from Literome

Juffermans et al., J Infect Dis 2000 (Endotoxemia...) : In healthy subjects, LPS induced a transient decrease in granulocyte CXCR1 and CXCR2 expression, whereas in tuberculosis patients, only CXCR2 showed reduced levels ... In whole blood in vitro, LPS , lipoarabinomannan from Mycobacterium tuberculosis, and lipoteichoic acid from Staphylococcus aureus reduced expression of CXCR2 but not of CXCR1
Tikhonov et al., Clin Exp Immunol 2001 : In contrast, LPS reduced CXCR1 and CXCR2 expression in purified PMN and whole blood in a TNF-alpha independent manner
van den Blink et al., J Clin Immunol 2004 (Endotoxemia) : The LPS induced reduction of neutrophil CXCR 1 and 2 expression, as determined by fluorescence activated cell sorter analysis, was inhibited in volunteers receiving the high dose of the p38 MAPK inhibitor
Leyva-Baca et al., Anim Genet 2008 : This study demonstrated that LPS induced expression of IL8RA in cows with the c.-1768AA genotype was significantly greater when compared with the c.-1768AT and c.-1768TT genotypes ( P < 0.05 ) before as well as after in vitro LPS challenge
Khandaker et al., J Immunol 1998 : In the present study, we investigated the mechanism by which bacterial LPS induces the down-modulation of IL-8 responsiveness and CXCR1 and CXCR2 expression on human neutrophils