Gene interactions and pathways from curated databases and text-mining

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HSPD1 — IRF6

Text-mined interactions from Literome

Schuchmann et al., Immunol Lett 2004 (Liver Failure) : HSP60 and CpG-DNA-oligonucleotides differentially regulate LPS-tolerance of hepatic Kupffer cells
Kilmartin et al., Eur J Immunol 2004 (Inflammation) : Addition of an anti-IL-10 neutralizing antibody had no significant effect on HSP60- or LPS induced tolerance.HSP60 priming of monocytes also results in significant down-regulation of HLA-DR, CD86 and Toll-like receptor 4 expression, but minimally up-regulates CD80 expression, similar to that previously reported with LPS
Bonior et al., J Physiol Pharmacol 2007 (Endotoxemia) : In spite of this observations the effects of LPS and caerulein on pro-apoptotic HSP60 and Bax protein expression in the pancreatic acinar cells has not been examined yet
Teng et al., Mol Med Report 2013 : Our data showed that LPS induced the activation of nuclear factor-?B ( NF-?B ) and its upstream protein caspase 3, upregulated the expression of an additional apoptosis-inducing factor, heat shock protein 60 (HSP60), in BV2 microglial cells and increased the release of TNF-a and HSP60 in the culture media ... Furthermore, the enhanced expression of HSP60 was reduced and the LPS induced release of TNF-a and HSP60 were inhibited
Seitz et al., Lab Invest 1996 : Increased coordinated LPS dependent expression of hsp60 and ICAM-1 correlates with monocyte and T-cell adhesion to aortic endothelium
Amberger et al., Cell Stress Chaperones 1997 (Arteriosclerosis) : Escherichia coli lipopolysaccharide (LPS) , native and oxidized low-density lipoprotein ( LDL ; oxLDL ) and high temperature to induce adhesion molecules as well as Hsp60 and Hsp70 expression in human endothelial cells ( EC )