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FOXO3 — RELA
Text-mined interactions from Literome
Mitsiades et al., Oncogene 2002
(Multiple Myeloma) :
In contrast, IL-6 does not cause sustained
NF-kappaB activation,
induces less pronounced Akt activation and
FKHRL-1 phosphorylation than IGF-1, and increases the expression of only survivin
Su et al., Immunity 2004
(Lymphoproliferative Disorders) :
Another fork in the road
: Foxo3a regulates
NF-kappaB activation
Lin et al., Immunity 2004
(Hypersensitivity...) :
Regulation of
NF-kappaB , Th activation, and autoinflammation by the forkhead transcription factor
Foxo3a ...
Foxo3a inhibits
NF-kappaB activation, whose overactivity was responsible for T cell hyperactivity in Foxo3a-deficient mice ... Thus,
Foxo3a regulates helper T cell activation and tolerance by inhibiting
NF-kappaB activity, reinforcing a generalized role for the forkhead proteins in the maintenance of T cell tolerance through the inhibition of inflammatory transcriptional activities
Terragni et al., BMC cell biology 2008
:
Phosphatidylinositol 3-kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of
FOXO and non-canonical
activation of
NFkappaB transcription factors
Zhou et al., Gastroenterology 2009
(Colitis...) :
Mechanistically,
FoxO4 inhibited the transcriptional activity of
nuclear factor-kappaB (NF-kappaB) , and Foxo4 deficiency is associated with increased NF-kappaB activity in vivo