◀ Back to NOS1
NOS1 — TGFB1
Text-mined interactions from Literome
Morbidelli et al., Int J Biochem Cell Biol 2001
:
NOS inhibition
reduced the basal expression of VEGF isoforms, while it markedly potentiated
TGF-beta1 expression
Saura et al., Circ Res 2002
:
Smad2 mediates
transforming growth factor-beta induction of endothelial
nitric oxide synthase expression
Schini et al., Eur J Pharmacol 1992
:
The induction of
nitric oxide synthase activity is
inhibited by
TGF-beta 1 , PDGFAB and PDGFBB in vascular smooth muscle cells
Boche et al., Neurobiol Dis 2006
(Chronic Disease...) :
In contrast, inhibition of
TGFbeta1 activity using an adenovirus expressing decorin
induces severe cerebral inflammation, expression of inducible
nitric oxide synthase and acute neuronal death in prion diseased animals only
Hamby et al., Prostaglandins Other Lipid Mediat 2008
:
TGF-beta1 reduces the heterogeneity of astrocytic cyclooxygenase-2 and
nitric oxide synthase-2 gene expression in a stimulus independent manner
Surachetpong et al., PLoS Pathog 2009
(MAP Kinase Signaling System) :
At the highest treatment dose of TGF-beta1, inhibition of ERK phosphorylation increased
TGF-beta1 induced expression of the anti-parasite effector gene
nitric oxide synthase (NOS) , suggesting that increasing levels of ERK activation negatively feed back on induced NOS expression
Koide et al., Hypertension 1994
:
These findings suggest that interferon gamma directly induces the expression of the inducible
nitric oxide synthase gene, whereas tumor necrosis factor-alpha and interleukin-1 beta induce it, at least in part, via the induction of intermediary protein ( s ), and that
transforming growth factor-beta 1 inhibits cytokine induced nitric oxide production by blocking the posttranscriptional synthesis of inducible nitric oxide synthase
Inoue et al., Arterioscler Thromb Vasc Biol 1995
:
Molecular
regulation of the bovine endothelial cell
nitric oxide synthase by
transforming growth factor-beta 1
Goureau et al., Proc Natl Acad Sci U S A 1993
:
Differential
regulation of inducible
nitric oxide synthase by fibroblast growth factors and
transforming growth factor beta in bovine retinal pigmented epithelial cells : inverse correlation with cellular proliferation
Vodovotz et al., J Exp Med 1996
(Alzheimer Disease) :
In mice,
NOS2 is normally
suppressed by
transforming growth factor beta 1 ( TGF-beta 1 )
Vincent et al., Glia 1997
:
Inhibition of endotoxin induced
nitric oxide synthase production in microglial cells by the presence of astroglial cells : a
role for
transforming growth factor beta
Mabley et al., J Endocrinol 1997
:
Transforming growth factor beta 1 prevents cytokine mediated inhibitory effects and induction of
nitric oxide synthase in the RINm5F insulin containing beta-cell line