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PTGS2 — SIL1

Text-mined interactions from Literome

Ho et al., J Toxicol Environ Health 2002 (Adenocarcinoma...) : The involvement of COX-2 in BaP activation was confirmed by transfection of H460 cells with a recombinant adenovirus, Ad-pgk-Cox2, coding for COX-2, which resulted in a significant increase in the levels of the COX-2 product prostaglandin E2 in the medium and in the susceptibility of H460 cells to BaP
Chang et al., Carcinogenesis 2007 : BaP induces COX-2 expression, and an interaction between BaP and estrogen in relation to COX-2 expression is suspected ... In the present study, 10 muM BaP alone only slightly increased COX-2 mRNA expression and 10 nM 17-beta estradiol ( E ( 2 ) ) alone slightly increased prostaglandin E2 ( PGE2 ) secretion in human bronchial epithelial cells ... Utilizing specific inhibitors and reporter assays, we further investigated the potentiation mechanisms of E ( 2 ) on BaP induced COX-2 expression ... Third, although the aryl hydrocarbon receptor (AhR) did not play a role in BaP induced COX-2 expression, the potentiation effect of E ( 2 ) itself was AhR dependent ... Our findings that the BaP-E ( 2 ) interaction enhanced COX-2 expression and hydroxyestradiol accumulation in the media of cultivated lung cells and tissues provide the needed scientific basis for higher risk of BaP associated lung cancer in females
Bugiak et al., Aquat Toxicol 2009 : In contrast, ANF antagonized TCDD and BaP induced COX-2b and TCDD induced CYP1C1 expression increases, as well as reduced baseline CYP1B1 and COX-2a expression in liver, while failing to affect BaP and TCDD induced hepatic CYP1A increases