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BCR — CRKL
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
CRKL
—
BCR
(direct interaction, two hybrid)
Kolibaba et al., Leukemia & lymphoma 1999*
-
IRef Biogrid Interaction:
CRKL
—
BCR
(direct interaction, two hybrid)
Bai et al., Oncogene 1998*
-
IRef Biogrid Interaction:
CRKL
—
BCR
(direct interaction, two hybrid)
Heaney et al., Blood 1997*
-
IRef Biogrid Interaction:
CRKL
—
BCR
(physical association, affinity chromatography technology)
Heaney et al., Blood 1997*
-
IRef Biogrid Interaction:
CRKL
—
BCR
(physical association, affinity chromatography technology)
Million et al., Mol Cell Biol 2004*
-
IRef Biogrid Interaction:
CRKL
—
BCR
(direct interaction, far western blotting)
Kolibaba et al., Leukemia & lymphoma 1999*
-
IRef Hprd Interaction:
CRKL
—
BCR
(two hybrid)
Heaney et al., Blood 1997*
-
IRef Hprd Interaction:
CRKL
—
BCR
(in vitro)
Heaney et al., Blood 1997*
Text-mined interactions from Literome
Rhodes et al., Exp Hematol 2000
:
Additionally, in the
presence of
Bcr-Abl ,
CrkL is found in the nucleus, can be detected in a Stat5/DNA complex, and increases transcriptional activation from a Stat-responsive reporter construct
Ingham et al., J Biol Chem 1996
:
We show that engaging the
B cell antigen receptor (BCR) on the RAMOS B cell line
caused both
Crk-L and Crk II to associate with several tyrosine phosphorylated proteins
Heaney et al., Blood 1997
(Cell Transformation, Neoplastic) :
Thus, a direct interaction of CRKL and
BCR-ABL is not
required for
CRKL to become tyrosine phosphorylated by BCR-ABL and suggests that CRKL function may still be required for BCR-ABL function through an indirect interaction