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AR — BRCA1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: AR → BRCA1 (decreases, BRCA1 Activity)
  Evidence: The role of BRCA1 in cancer development is unclear. In addition to its ability to coactivate p53 and to modulate p300/CBP expression, BRCA1 is also a ligand-independent corepressor for the ER, the androgen receptor and the PR [35]. If BRCA1 is mutated, all of these pathways will be more or less impaired.
• OpenBEL Selventa BEL large corpus: AR → BRCA1 (directlyIncreases, BRCA1 Activity) Yeh et al., Proc Natl Acad Sci U S A 2000*
  Evidence: Here, we report that BRCA1 interacts with androgen receptor (AR) and enhances AR target genes, such as p21((WAF1/CIP1)), that may result in the increase of androgen-induced cell death in prostate cancer cells.
• NCI Pathway Database Coregulation of Androgen receptor activity: BRCA1 (BRCA1) → AR/T-DHT complex (AR) (transcription, activates) Yeh et al., Proc Natl Acad Sci U S A 2000*
  Evidence: reporter gene

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: AR — BRCA1 (direct interaction, pull down) Park et al., Cancer Res 2000*
• IRef Biogrid Interaction: AR — BRCA1 (direct interaction, pull down) Yeh et al., Proc Natl Acad Sci U S A 2000*
• IRef Biogrid Interaction: AR — BRCA1 (direct interaction, two hybrid) Yeh et al., Proc Natl Acad Sci U S A 2000*
• IRef Dip Interaction: AR — BRCA1 (physical association, affinity chromatography technology) Park et al., Cancer Res 2000*
• IRef Hprd Interaction: AR — BRCA1 (in vitro) Yeh et al., Proc Natl Acad Sci U S A 2000*, Park et al., Cancer Res 2000*
• IRef Ophid Interaction: AR — BRCA1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Yeh et al., Proc Natl Acad Sci U S A 2000 (Prostatic Neoplasms) : Increase of androgen induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells
Rosen et al., Trends Endocrinol Metab 2003 (Breast Neoplasms...) : Recent studies indicate that BRCA1 interacts with and regulates the activity of estrogen receptor alpha (ER alpha) and the androgen receptor