◀ Back to AHR
AHR — IL2RA
Text-mined interactions from Literome
Joetham et al., J Immunol 2007
(Hypersensitivity...) :
Significantly, CD4 ( + )
CD25 ( + ) T cells isolated from IL-10 ( -/- ) mice had no effect on AHR and inflammation, but when incubated with rIL-10 before transfer,
suppressed AHR , and inflammation, and was associated with elevated levels of bronchoalveolar lavage TGF-beta levels
Joetham et al., Proc Natl Acad Sci U S A 2007
(Hypersensitivity...) :
Naturally occurring Foxp3 ( + ) CD4 ( + )
CD25 ( + ) T cells ( nTregs ) isolated from lungs of naive mice
regulate allergic
airway hyperresponsiveness (AHR) and inflammation
Funatake et al., J Immunotoxicol 2008
(Graft vs Host Disease) :
When CD4+ and CD8+ donor T-cells from AhR-WT and AhR-KO mice were injected in various combinations into F1 mice, the enhanced expression of
CD25 on CD8+ T-cells
required AhR in donor CD4+ T-cells, while down-regulation of CD62L required AhR in the donor CD8+ T-cells themselves
Kerkvliet et al., Biochem Pharmacol 2009
:
With TCDD, most adaptive immune responses are highly suppressed, which has been recently linked to the
AHR dependent
induction of CD4 ( + )
CD25 ( + ) regulatory T cells
Funatake et al., J Immunotoxicol 2009
(Disease Models, Animal...) :
Expression of
CA-AhR in donor T-cells enhanced the down-regulation of CD62L on Day 2 after injection, similar to a single oral dose of TCDD, but did not
induce up-regulation of
CD25 on Day 2 or affect CTL activity on Day 10