Gene interactions and pathways from curated databases and text-mining

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AHR — IL2RA

Text-mined interactions from Literome

Joetham et al., J Immunol 2007 (Hypersensitivity...) : Significantly, CD4 ( + ) CD25 ( + ) T cells isolated from IL-10 ( -/- ) mice had no effect on AHR and inflammation, but when incubated with rIL-10 before transfer, suppressed AHR , and inflammation, and was associated with elevated levels of bronchoalveolar lavage TGF-beta levels
Joetham et al., Proc Natl Acad Sci U S A 2007 (Hypersensitivity...) : Naturally occurring Foxp3 ( + ) CD4 ( + ) CD25 ( + ) T cells ( nTregs ) isolated from lungs of naive mice regulate allergic airway hyperresponsiveness (AHR) and inflammation
Funatake et al., J Immunotoxicol 2008 (Graft vs Host Disease) : When CD4+ and CD8+ donor T-cells from AhR-WT and AhR-KO mice were injected in various combinations into F1 mice, the enhanced expression of CD25 on CD8+ T-cells required AhR in donor CD4+ T-cells, while down-regulation of CD62L required AhR in the donor CD8+ T-cells themselves
Kerkvliet et al., Biochem Pharmacol 2009 : With TCDD, most adaptive immune responses are highly suppressed, which has been recently linked to the AHR dependent induction of CD4 ( + ) CD25 ( + ) regulatory T cells
Funatake et al., J Immunotoxicol 2009 (Disease Models, Animal...) : Expression of CA-AhR in donor T-cells enhanced the down-regulation of CD62L on Day 2 after injection, similar to a single oral dose of TCDD, but did not induce up-regulation of CD25 on Day 2 or affect CTL activity on Day 10