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IL13 — JAK3

Text-mined interactions from Literome

Li et al., J Immunol 1999 (Asthma) : IL-13 was able to induce eotaxin in the lung of JAK3-deficient mice, suggesting that JAK3 is not required for IL-13 signaling in airway epithelial cells ; however, eosinophilia was not induced in this situation, suggesting that JAK3 transduces other IL-13 mediated mechanisms critical for eosinophil recruitment
Doucet et al., Oncogene 2000 (Lung Neoplasms...) : In addition to these pathways, in lung tumor myofibroblasts, IL-4 and IL-13 induced the phosphorylation of JAK3 and increased the phosphorylation of Tyk2
Doucet et al., Eur J Immunol 2002 (Inflammation) : Here we show that in normal lung fibroblasts IL-4 and IL-13 induce the expression of the gamma c chain and its association with Janus kinase (JAK) 3 , while lung myofibroblasts constitutively express a gamma c chain displaying a limited association with JAK3
To et al., Br J Cancer 2004 (Cell Transformation, Neoplastic...) : The interleukin mediated Janus kinase ( JAK ) /STAT pathway plays a crucial role in carcinogenesis
Russell et al., Islets 2013 : Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic ß-cells
Keegan et al., Proc Natl Acad Sci U S A 1995 : Interestingly, although IL-4 induced the tyrosine phosphorylation of JAK3, we did not detect JAK3 phosphorylation in response to IL-13 ... However, our data further indicate that there are significant differences because IL-13 does not activate JAK3
Izuhara et al., J Biol Chem 1996 (Severe Combined Immunodeficiency) : However, Jak3 was not activated by IL-13 , even in normal B cells
Murata et al., J Immunol 1996 (Colonic Neoplasms) : IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines : similarities between IL-4 and IL-13 signaling
Malabarba et al., Biochem J 1996 (Leukemia, Erythroblastic, Acute) : Interleukin-13 is a potent activator of JAK3 and STAT6 in cells expressing interleukin-2 receptor-gamma and interleukin-4 receptor-alpha
Yu et al., J Immunol 1998 : Furthermore, we demonstrate that IL-13 , like IL-4, induces distinct STAT6-DNA binding complexes and tyrosine phosphorylation of STAT6 and Janus kinase 3 (JAK3) in NK and T cells