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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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GLI3 — WNT3

Pathways - manually collected, often from reviews:

  • KEGG Hedgehog signaling pathway: GLI1/GLI2/GLI3 → WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B (gene expression, expression)
  • KEGG Pathways in cancer: GLI1/GLI2/GLI3 → WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B (gene expression, expression)
  • KEGG Basal cell carcinoma: GLI1/GLI2/GLI3 → WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B (gene expression, expression)

Text-mined interactions from Literome

Ulloa et al., Curr Biol 2007 : Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling
Alvarez-Medina et al., Development 2008 : Additionally, we show that Gli3 expression is controlled by Wnt activity ... These indicated that dorsal Gli3 expression might be directly regulated by canonical Wnt activity
Martinez-Ferre et al., J Neurosci 2013 : Early Wnt expression in the ZLI regulates Gli3 and L-fng to generate a permissive territory in which Shh is progressively induced by planar signals of the basal plate