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PLAU — SRC
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Irigoyen et al., Biochem Biophys Res Commun 1999
:
Furthermore, expression of either FRNK, a kinase-minus FAK-like molecule acting as a dominant negative FAK, or a dominant negative
Src suppressed CSR induced
uPA gene promoter activation
Shin et al., J Cancer Res Clin Oncol 2002
(Neoplasm Invasiveness...) :
However, only inhibition of
Src and ERK could
block KGF stimulated secretion of
uPA and MMP-9
Faisal et al., J Biol Chem 2004
:
In a quest for molecules upstream of ShcA in this signaling, we found that CSR induced ShcA tyrosine phosphorylation, its association with Grb2, Erk activation, and
uPA gene expression were all
dependent on Rho kinase, p38 mitogen activated protein kinase, and
Src
Das et al., J Biol Chem 2004
(Breast Neoplasms...) :
To our knowledge, this is the first report that OPN induces alpha(v)beta(3) integrin mediated AP-1 activity and uPA secretion by activating c-Src/EGFR/ERK signaling pathways and further demonstrates a functional molecular link between OPN induced
integrin/c-Src dependent EGFR phosphorylation and ERK/AP-1 mediated
uPA secretion, and all of these ultimately control the motility of breast cancer cells
Estrella et al., Int J Oncol 2007
(MAP Kinase Signaling System...) :
Further, tyrosine phosphorylation and functional
Src were
required for optimal
uPA secretion
Amos et al., J Neuropathol Exp Neurol 2010
(Glioblastoma...) :
In summary, these results suggest that
c-Src , mitogen activated protein kinase, and a composite activator protein 1 on the uPA promoter are
responsible for EGF induced
uPA expression and GBM invasion