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UCSC Genome Browser Gene Interaction Graph
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Gene interactions and pathways from curated databases and text-mining
◀ Back to EIF4G1
EIF4A1 — EIF4G1
Pathways - manually collected, often from reviews:
BioCarta mtor signaling pathway :
eukaryotic translation initiation factor 4 gamma 1 (EIF4G1)
→
EIF-4A (EIF4A1)
(modification, collaborate)
BioCarta mtor signaling pathway :
eukaryotic translation initiation factor 4 gamma 1 (EIF4G1)
→
EIF-4E/EIF-4G/EIF-4A/eIF-4B/RNA strand/eIF3/40s Ribosome subunit complex (EIF4E-EIF4G1-EIF4A1-EIF4B-EIF3S10)
(modification, collaborate)
BioCarta mtor signaling pathway :
eIF3 (EIF3S10)
→
EIF-4E/EIF-4G/EIF-4A/eIF-4B/RNA strand/eIF3/40s Ribosome subunit complex (EIF4E-EIF4G1-EIF4A1-EIF4B-EIF3S10)
(modification, collaborate)
BioCarta mtor signaling pathway :
EIF-4E (EIF4E)
→
EIF-4E/EIF-4G/EIF-4A/eIF-4B/RNA strand/eIF3/40s Ribosome subunit complex (EIF4E-EIF4G1-EIF4A1-EIF4B-EIF3S10)
(modification, collaborate)
BioCarta mtor signaling pathway :
EIF-4A (EIF4A1)
→
EIF-4E/EIF-4G/EIF-4A/eIF-4B/RNA strand/eIF3/40s Ribosome subunit complex (EIF4E-EIF4G1-EIF4A1-EIF4B-EIF3S10)
(modification, collaborate)
BioCarta mtor signaling pathway :
EIF-4E/EIF-4G/EIF-4A/eIF-4B/RNA strand/eIF3/40s Ribosome subunit complex (EIF4E-EIF4G1-EIF4A1-EIF4B-EIF3S10)
→
eIF-4B (EIF4B)
(modification, collaborate)
BioCarta mtor signaling pathway :
EIF-4E/EIF-4G/EIF-4A/eIF-4B/RNA strand/eIF3/40s Ribosome subunit complex (EIF4E-EIF4G1-EIF4A1-EIF4B-EIF3S10)
(modification, collaborate)
BioCarta mtor signaling pathway :
EIF-4A (EIF4A1)
→
eukaryotic translation initiation factor 4 gamma 1 (EIF4G1)
(modification, collaborate)
BioCarta mtor signaling pathway :
EIF-4A (EIF4A1)
→
EIF-4E/EIF-4G/EIF-4A complex (EIF4E-EIF4G1-EIF4A1)
(modification, collaborate)
BioCarta mtor signaling pathway :
eukaryotic translation initiation factor 4 gamma 1 (EIF4G1)
→
EIF-4E/EIF-4G/EIF-4A complex (EIF4E-EIF4G1-EIF4A1)
(modification, collaborate)
BioCarta mtor signaling pathway :
EIF-4E (EIF4E)
→
EIF-4E/EIF-4G/EIF-4A complex (EIF4E-EIF4G1-EIF4A1)
(modification, collaborate)
BioCarta mtor signaling pathway :
Mnk1 (MKNK1)
→
EIF-4E/EIF-4G/EIF-4A complex (EIF4E-EIF4G1-EIF4A1)
(modification, activates)
BioCarta internal ribosome entry pathway :
eIF-4G/eIF3/EIF-4A complex (EIF4G1-EIF4G2-EIF4G3-EIF3S10-EIF4A1)
→
eIF-4G/eIF-4E/PTB complex (EIF4G1-EIF4G2-EIF4G3-EIF4E-PTBP1_PTBP2)
(translational initiation, activates)
BioCarta mtor signaling pathway :
EIF-4E/EIF-4G/EIF-4A/eIF-4B/RNA strand complex (EIF4E-EIF4G1-EIF4A1-EIF4B)
→
EIF-4E/EIF-4G/EIF-4A complex (EIF4E-EIF4G1-EIF4A1)
(modification, collaborate)
BioCarta mtor signaling pathway :
EIF-4E/EIF-4G/EIF-4A/eIF-4B/RNA strand complex (EIF4E-EIF4G1-EIF4A1-EIF4B)
→
eIF-4B (EIF4B)
(modification, collaborate)
BioCarta mtor signaling pathway :
EIF-4E/EIF-4G/EIF-4A complex (EIF4E-EIF4G1-EIF4A1)
→
eIF-4B (EIF4B)
(modification, collaborate)
BioCarta skeletal muscle hypertrophy is regulated via akt-mtor pathway :
PABP/EIF-4F complex (EIF4E-EIF4G1-EIF4A1-PABPC1)
→
48S/S6 complex (PSMC4-EIF4G1-PABPC1-EIF4E-EIF4A1)
(modification, collaborate)
BioCarta skeletal muscle hypertrophy is regulated via akt-mtor pathway :
PABP/EIF-4F complex (EIF4E-EIF4G1-EIF4A1-PABPC1)
(modification, collaborate)
BioCarta skeletal muscle hypertrophy is regulated via akt-mtor pathway :
48S/S6 complex (PSMC4-EIF4G1-PABPC1-EIF4E-EIF4A1)
(modification, collaborate)
BioCarta mtor signaling pathway :
EIF-4E/EIF-4G/EIF-4A/eIF-4B/RNA strand complex (EIF4E-EIF4G1-EIF4A1-EIF4B)
→
RPS6(+)/eIF3/40s Ribosome subunit complex (RPS6-EIF3S10)
(modification, collaborate)
BioCarta mtor signaling pathway :
EIF-4E/EIF-4G/EIF-4A/eIF-4B/RNA strand complex (EIF4E-EIF4G1-EIF4A1-EIF4B)
→
EIF-4E/EIF-4G/EIF-4A/eIF-4B/RNA strand/eIF3/40s Ribosome subunit complex (EIF4E-EIF4G1-EIF4A1-EIF4B-EIF3S10)
(modification, collaborate)
BioCarta mtor signaling pathway :
EIF-4E/EIF-4G/EIF-4A/eIF-4B/RNA strand complex (EIF4E-EIF4G1-EIF4A1-EIF4B)
→
RPS6
(modification, collaborate)
BioCarta mtor signaling pathway :
RPS6(+)/eIF3/40s Ribosome subunit complex (RPS6-EIF3S10)
→
EIF-4E/EIF-4G/EIF-4A/eIF-4B/RNA strand/eIF3/40s Ribosome subunit complex (EIF4E-EIF4G1-EIF4A1-EIF4B-EIF3S10)
(modification, collaborate)
BioCarta mtor signaling pathway :
EIF-4E/EIF-4G/EIF-4A/eIF-4B/RNA strand/eIF3/40s Ribosome subunit complex (EIF4E-EIF4G1-EIF4A1-EIF4B-EIF3S10)
→
RPS6
(modification, collaborate)
BioCarta internal ribosome entry pathway :
eIF-4G/eIF-4E/PTB complex (EIF4G1-EIF4G2-EIF4G3-EIF4E-PTBP1_PTBP2)
→
eIF-4G/eIF3/EIF-4A complex (EIF4G1-EIF4G2-EIF4G3-EIF3S10-EIF4A1)
(modification, collaborate)
BioCarta internal ribosome entry pathway :
eIF-4G/eIF-4E/PTB complex (EIF4G1-EIF4G2-EIF4G3-EIF4E-PTBP1_PTBP2)
→
c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2)
(modification, collaborate)
BioCarta internal ribosome entry pathway :
eIF-4G/eIF3/EIF-4A complex (EIF4G1-EIF4G2-EIF4G3-EIF3S10-EIF4A1)
→
c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2)
(modification, collaborate)
BioCarta internal ribosome entry pathway :
Active caspases (CASP5/CASP3/CASP4/CASP8/CASP1/CASP7/CASP6/CASP2/CASP9/CASP10)
→
eIF-4G/eIF3/EIF-4A complex (EIF4G1-EIF4G2-EIF4G3-EIF3S10-EIF4A1)
(modification, activates)
BioCarta internal ribosome entry pathway :
Active caspases (CASP5/CASP3/CASP4/CASP8/CASP1/CASP7/CASP6/CASP2/CASP9/CASP10)
→
c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2)
(modification, activates)
BioCarta internal ribosome entry pathway :
eIF-4G/eIF-4E/PTB complex (EIF4G1-EIF4G2-EIF4G3-EIF4E-PTBP1_PTBP2)
→
eIF-4G/eIF3/EIF-4A complex (EIF4G1-EIF4G2-EIF4G3-EIF3S10-EIF4A1)
(modification, collaborate)
BioCarta internal ribosome entry pathway :
eIF-4G/eIF-4E/PTB complex (EIF4G1-EIF4G2-EIF4G3-EIF4E-PTBP1_PTBP2)
→
c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2)
(modification, collaborate)
BioCarta internal ribosome entry pathway :
eIF-4G/eIF3/EIF-4A complex (EIF4G1-EIF4G2-EIF4G3-EIF3S10-EIF4A1)
→
c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2)
(modification, collaborate)
BioCarta mtor signaling pathway :
EIF-4A (EIF4A1)
→
eukaryotic translation initiation factor 4 gamma 1 (EIF4G1)
(modification, collaborate)
BioCarta mtor signaling pathway :
EIF-4A (EIF4A1)
→
EIF-4E/EIF-4G/EIF-4A complex (EIF4E-EIF4G1-EIF4A1)
(modification, collaborate)
BioCarta mtor signaling pathway :
eukaryotic translation initiation factor 4 gamma 1 (EIF4G1)
→
EIF-4E/EIF-4G/EIF-4A complex (EIF4E-EIF4G1-EIF4A1)
(modification, collaborate)
BioCarta mtor signaling pathway :
EIF-4E (EIF4E)
→
EIF-4E/EIF-4G/EIF-4A complex (EIF4E-EIF4G1-EIF4A1)
(modification, collaborate)
BioCarta eukaryotic protein translation :
40s Ribosome subunit/RNA strand complex ()
→
48s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3-EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E)
(modification, collaborate)
BioCarta eukaryotic protein translation :
eIF3 (EIF3S10)
→
48s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3-EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E)
(modification, collaborate)
BioCarta eukaryotic protein translation :
eIF1 (EIF1)
→
48s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3-EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E)
(modification, activates)
BioCarta eukaryotic protein translation :
48s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3-EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E)
→
EIF-2 complex (EIF2S1-EIF2S2-EIF2S3)
(modification, collaborate)
BioCarta internal ribosome entry pathway :
PTB (PTBP1/PTBP2)
→
c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2)
(modification, collaborate)
BioCarta internal ribosome entry pathway :
eIF3 (EIF3S10)
→
c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2)
(modification, collaborate)
BioCarta internal ribosome entry pathway :
c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2)
→
EIF-4E (EIF4E)
(modification, collaborate)
BioCarta internal ribosome entry pathway :
c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2)
→
EIF-4A (EIF4A1)
(modification, collaborate)
BioCarta internal ribosome entry pathway :
c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2)
→
eIF-4G (dimer) complex (EIF4G1-EIF4G2-EIF4G3)
(modification, collaborate)
BioCarta internal ribosome entry pathway :
EIF-4A (EIF4A1)
→
eIF-4G (dimer) complex (EIF4G1-EIF4G2-EIF4G3)
(modification, collaborate)
BioCarta skeletal muscle hypertrophy is regulated via akt-mtor pathway :
EIF-4A (EIF4A1)
→
eukaryotic translation initiation factor 4 gamma 1 (EIF4G1)
(modification, collaborate)
BioCarta skeletal muscle hypertrophy is regulated via akt-mtor pathway :
EIF-4A (EIF4A1)
→
EIF-4F complex (EIF4G1-EIF4E-EIF4A1)
(modification, collaborate)
BioCarta skeletal muscle hypertrophy is regulated via akt-mtor pathway :
eukaryotic translation initiation factor 4 gamma 1 (EIF4G1)
→
EIF-4F complex (EIF4G1-EIF4E-EIF4A1)
(modification, collaborate)
BioCarta skeletal muscle hypertrophy is regulated via akt-mtor pathway :
EIF-4E (EIF4E)
→
EIF-4F complex (EIF4G1-EIF4E-EIF4A1)
(modification, collaborate)
BioCarta skeletal muscle hypertrophy is regulated via akt-mtor pathway :
Mnk1 (MKNK1)
→
EIF-4F complex (EIF4G1-EIF4E-EIF4A1)
(modification, activates)
BioCarta regulation of eif-4e and p70s6 kinase :
48S/S6 complex (PSMC4-EIF4G1-PABPC1-EIF4E-EIF4A1)
→
p70S6K (RPS6KB1)
(transcription, collaborate)
BioCarta skeletal muscle hypertrophy is regulated via akt-mtor pathway :
PABP/EIF-4F complex (EIF4E-EIF4G1-EIF4A1-PABPC1)
→
EIF-4F complex (EIF4G1-EIF4E-EIF4A1)
(modification, collaborate)
BioCarta skeletal muscle hypertrophy is regulated via akt-mtor pathway :
PABP/EIF-4F complex (EIF4E-EIF4G1-EIF4A1-PABPC1)
→
PABP (PABPC1)
(modification, collaborate)
BioCarta skeletal muscle hypertrophy is regulated via akt-mtor pathway :
EIF-4F complex (EIF4G1-EIF4E-EIF4A1)
→
PABP (PABPC1)
(modification, collaborate)
BioCarta eukaryotic protein translation :
43s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3)
→
48s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3-EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E)
(modification, collaborate)
BioCarta eukaryotic protein translation :
43s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3)
→
eIF4F/mRNA complex (EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E)
(modification, collaborate)
BioCarta eukaryotic protein translation :
48s Ribosome subunit complex (EIF3S10-EIF2S1-EIF2S2-EIF2S3-EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E)
→
eIF4F/mRNA complex (EIF4A1-EIF4A2-EIF4G1-EIF4G2-EIF4G3-EIF4E)
(modification, collaborate)
KEGG RNA transport :
EIF4G1/EIF4G2/EIF4G3
→
EIF4A1/EIF4A2
(protein-protein, binding/association)
Reactome Reaction :
EIF4A1
→
EIF4G1
(reaction)
Albert et al., Nucleic Acids Res 2000 , Pestova et al., Nature 2000 , Gao et al., Mol Cell 2000 , Asano et al., Genes Dev 2000 , Wilusz et al., Nat Rev Mol Cell Biol 2001 , Chen et al., EMBO J 2002 , Aström et al., J Biol Chem 1992 , Parker et al., Nature structural & molecular biology 2004 , Fritz et al., Cell Biochem Biophys 2004 , Moore et al., Science 2005 , Yamashita et al., Nature structural & molecular biology 2005 , Kim et al., Mol Cell 2006 , Garneau et al., Nat Rev Mol Cell Biol 2007 , Chakrabarti et al., J Biol Chem 1991 , Zheng et al., J Cell Biol 2008 , Houseley et al., Cell 2009 , Lau et al., Biochem J 2009 , Peterson et al., J Biol Chem 1979 , Trachsel et al., J Mol Biol 1977 , Benne et al., J Biol Chem 1978 , Yoder-Hill et al., J Biol Chem 1993 * , Körner et al., J Biol Chem 1997
Reactome Reaction :
EIF4A1
→
EIF4G1
(indirect_complex)
Yoder-Hill et al., J Biol Chem 1993 *
Reactome Reaction :
EIF4A1
→
EIF4G1
(direct_complex)
Wilusz et al., Nat Rev Mol Cell Biol 2001 , Uchida et al., J Biol Chem 2004 , Parker et al., Nature structural & molecular biology 2004 , Fritz et al., Cell Biochem Biophys 2004 , Moore et al., Science 2005 , Yamashita et al., Nature structural & molecular biology 2005 , Garneau et al., Nat Rev Mol Cell Biol 2007 , Okumura et al., Genes Dev 2007 , Siddiqui et al., J Biol Chem 2007 , Zheng et al., J Cell Biol 2008 , Houseley et al., Cell 2009
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
IRef Biogrid Interaction :
EIF4A1
—
EIF4G1
(physical association, affinity chromatography technology)
Dorrello et al., Science 2006
IRef Biogrid Interaction :
EIF4A1
—
EIF4G1
(physical association, affinity chromatography technology)
Kroczynska et al., Mol Cell Biol 2012 *
IRef Biogrid Interaction :
EIF4A1
—
EIF4G1
(colocalization, biochemical)
Havugimana et al., Cell 2012
IRef Biogrid Interaction :
EIF4A1
—
EIF4G1
(physical association, affinity chromatography technology)
Ewing et al., Molecular systems biology 2007
IRef Biogrid Interaction :
EIF4A1
—
EIF4G1
(physical association, affinity chromatography technology)
Connolly et al., Mol Cell Biol 2006 *
IRef Biogrid Interaction :
EIF4A1
—
EIF4G1
(physical association, affinity chromatography technology)
Harris et al., EMBO J 2006 *
MIPS CORUM MNK1-eIF4F complex :
MNK1-eIF4F complex complex (EIF4A1-EIF4E-MKNK1-EIF4G1-EIF4G2)
Pyronnet et al., EMBO J 1999
IRef Corum Interaction :
Complex of EIF4E-EIF4G1-EIF4A1-EIF4G2-MKNK1
(association, anti bait coimmunoprecipitation)
Pyronnet et al., EMBO J 1999
IRef Dip Interaction :
EIF4G1
—
EIF4A1
(direct interaction, dynamic light scattering)
Schütz et al., Proc Natl Acad Sci U S A 2008 *
IRef Dip Interaction :
EIF4G1
—
EIF4A1
(direct interaction, molecular sieving)
Schütz et al., Proc Natl Acad Sci U S A 2008 *
IRef Dip Interaction :
EIF4G1
—
EIF4A1
(direct interaction, isothermal titration calorimetry)
Virgili et al., Structure 2013 *
IRef Dip Interaction :
EIF4G1
—
EIF4A1
(direct interaction, molecular sieving)
Virgili et al., Structure 2013 *
IRef Hprd Interaction :
EIF4A1
—
EIF4G1
(in vitro)
Li et al., J Biol Chem 2001 * , Imataka et al., Mol Cell Biol 1997 *
IRef Hprd Interaction :
EIF4A1
—
EIF4G1
(in vivo)
Li et al., J Biol Chem 2001 * , Imataka et al., Mol Cell Biol 1997 *
IRef Intact Interaction :
EIF4G1
—
EIF4A1
(direct interaction, surface plasmon resonance)
Marintchev et al., Cell 2009 *
IRef Intact Interaction :
EIF4G1
—
EIF4A1
(direct interaction, molecular sieving)
Marintchev et al., Cell 2009 *
IRef Intact Interaction :
EIF4G1
—
EIF4A1
(direct interaction, nuclear magnetic resonance)
Marintchev et al., Cell 2009 *
IRef Intact Interaction :
EIF4G1
—
EIF4A1
(physical association, anti tag coimmunoprecipitation)
Zhu et al., EMBO J 2012 *
IRef Intact Interaction :
EIF4G1
—
EIF4A1
(physical association, coimmunoprecipitation)
Li et al., J Biol Chem 2001 *
IRef Intact Interaction :
EIF4G1
—
EIF4A1
(physical association, pull down)
Li et al., J Biol Chem 2001 *
IRef Intact Interaction :
EIF4G1
—
EIF4A1
(physical association, anti tag coimmunoprecipitation)
Lee et al., EMBO J 2006 *
IRef Intact Interaction :
EIF4G1
—
EIF4A1
(physical association, pull down)
Lee et al., EMBO J 2006 *
IRef Intact Interaction :
EIF4G1
—
EIF4A1
(physical association, anti bait coimmunoprecipitation)
Ewing et al., Molecular systems biology 2007
IRef Intact Interaction :
Complex of 18 proteins
(physical association, tandem affinity purification)
Hutchins et al., Science 2010