◀ Back to GRAP2

DUSP1 — GRAP2

Text-mined interactions from Literome

Shi et al., Breast Cancer Res Treat 2006 (Breast Neoplasms) : Inhibition of p38 resulted in suppression of induction of anti-apoptotic MAPK phosphatase (MKP)-1 , in association with enhanced activation of the pro-apoptotic c-Jun-N-terminal kinase (JNK)
Hu et al., Cell Signal 2007 : Furthermore, inhibition of p38 by SB 203580 prevented the expression of MKP-1 in LPS tolerized macrophages, restored the activation of MAP kinases after LPS restimulation
Tephly et al., Am J Respir Cell Mol Biol 2007 : Since kinase activity is tightly regulated by phosphatases, we hypothesized that the dual specificity phosphatase MAP kinase phosphatase (MKP)-1 regulates p38 activity and TNF-alpha production in alveolar macrophages due to insufficient H ( 2 ) O ( 2 ) generation in response to asbestos
King et al., J Biol Chem 2009 : Adenoviral expression of MKP-1 profoundly reduces p38 MAPK phosphorylation and IL-8 expression
Rastogi et al., Am J Respir Crit Care Med 2011 (Sarcoidosis, Pulmonary) : Adenovirus mediated overexpression of MKP-1 attenuated p38 activation and decreased the production of IL12/IL23p40 and TNF-a in sarcoid BAL cells
Hsu et al., Biochim Biophys Acta 2011 : TSA suppression of JNK and p38MAPK phosphorylation and subsequent COX-2 expression were restored by selective inhibition of MKP-1 using MKP-1 siRNA
Ayush et al., J Invest Dermatol 2013 (Dermatitis, Contact...) : These results suggest that Gln suppresses DNFB induced CD via deactivation of p38 MAPK through the early induction of MKP-1 , the negative regulator of p38 , in an ERK dependent manner
Taylor et al., J Neurosci 2013 (Huntington Disease) : Overexpression of MKP-1 prevented the polyglutamine expanded huntingtin induced activation of c-Jun N-terminal kinases (JNKs) and p38 MAPKs, whereas extracellular signal regulated kinase ( ERK ) 1/2 activation was not altered by either polyglutamine expanded Htt or MKP-1