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LEP — UCN

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: LEP — UCN (in vivo) Kastin et al., Peptides 2002*
• IRef Hprd Interaction: LEP — UCN (in vitro) Kastin et al., Peptides 2002*

Text-mined interactions from Literome

Kotz et al., Am J Physiol Regul Integr Comp Physiol 2002 : Relative to food restricted control animals, UCN in the PVN significantly increased plasma leptin and UCP-1 mRNA in brown adipose tissue and decreased UCP-3 mRNA in acromiotrapezius muscle, suggesting a role for PVN UCN in the regulation of energy balance
Pan et al., J Mol Neurosci 2007 (Obesity) : After injection into the hypothalamus, urocortin can stimulate the release of leptin in the periphery
Nazarians-Armavil et al., Mol Endocrinol 2013 : Leptin directly repressed agouti related peptide mRNA levels but induced urocortin-2 , insulin receptor substrate (IRS)-1, IRS2, and IR transcription, through leptin mediated phosphatidylinositol 3-kinase/Akt activation ... Neuronal insulin resistance, as assessed by attenuated Akt phosphorylation, blocked leptin mediated signal transduction and agouti related peptide, urocortin-2 , IRS1, IRS2, and insulin receptor synthesis