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CXCL12 — KDR

Text-mined interactions from Literome

Petreaca et al., Mol Biol Cell 2007 : IL-8/CXCL8 stimulates VEGFR2 phosphorylation in a VEGF independent manner, suggesting VEGFR2 transactivation ... An inhibitor of Src kinases blocked IL-8/CXCL8 induced VEGFR2 phosphorylation, receptor complex formation, and endothelial permeability
Martin et al., J Biol Chem 2009 : CXCL8/IL8 stimulates vascular endothelial growth factor ( VEGF ) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM ( Carma3/Bcl10/Malt1 ) complex ... Here, we found that CXCL8/IL8 , a potent proangiogenic and inflammatory chemokine, up-regulates VEGF mRNA and protein levels in endothelial cells by acting on its cognate receptor, CXCR2, and that this results in the autocrine activation of VEGFR2
Walenta et al., Basic Res Cardiol 2011 : Migration assays revealed that SDF-1 , fractalkine, and LTB4 significantly increase migration of CD34 ( - ) /CD133 ( + ) /VEGFR2 ( + ) EPCs, while SDF-1 was the only potent agonist of migration of CD34 ( + ) /CD133 ( + ) /VEGFR2 ( + ) EPCs