Manna et al., J Biol Chem 2000
:
Protein tyrosine kinase p56lck is required for ceramide induced but not tumor necrosis factor induced activation of NF-kappa B, AP-1 , JNK, and apoptosis
Manna et al., J Immunol 2000
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Overall, our results demonstrate that p56lck plays a critical role in the activation of NF-kappa B, AP-1 , JNK, and apoptosis by HIV-tat protein but has minimal or no role in activation of these responses by TNF