Gene interactions and pathways from curated databases and text-mining

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BCL2 — IFNG

Text-mined interactions from Literome

Su et al., J Immunol 1999 (Burkitt Lymphoma) : Instead, IFN-alpha and IFN-beta, but not IFN-gamma , significantly increase the levels of the survival protein Bcl-2 , and to a lesser extent, Bcl-xL expression
Nishikawa et al., Parasitology 2001 (Coccidiosis) : The present study suggests that the IFN-gamma induced increases of FasL expression and down-regulated Bcl-2 expression in N. caninum infected cells are associated with apoptosis in vitro
Marselli et al., J Clin Endocrinol Metab 2001 : IL-1beta, interferon gamma , and TNF alpha caused no major change in either islet cell survival or Bcl-2 and Bax mRNA expression after a 12-h incubation ; however, a marked increase in the amount of dead cells, with a major decrease of Bcl-2 mRNA expression, was observed after 72 h
Liu et al., Cytokine 2003 : Effect of IFNgamma on caspase-3, Bcl-2 and Bax expression, and apoptosis in rabbit placenta
Zhou et al., J Interferon Cytokine Res 2008 (Leukemia) : IFN-gamma induces apoptosis in HL-60 cells through decreased Bcl-2 and increased Bak expression ... This study thus provides the basis for additional research to uncover the molecular mechanism by which IFN-gamma regulates the expression of Bcl-2 family members in various cell types