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ERBB2 — RAC1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Yang et al., Mol Cell Biol 2006
(Breast Neoplasms) :
Using specific ErbB receptor inhibitors and depletion of receptors by RNA interference ( RNAi ), we established that, surprisingly, activation of
Rac by HRG is
mediated not only by ErbB3 and
ErbB2 but also by transactivation of EGFR, and it is independent of ErbB4
Kawano et al., J Biol Chem 2009
:
ErbB2 and ErbB3, members of the EGF receptor/ErbB family, form a heterodimer upon binding of a ligand,
inducing the activation of
Rac small G protein and Akt protein kinase for cell movement and survival, respectively
Johnson et al., J Biol Chem 2010
(Breast Neoplasms) :
ErbB2 induction of migration
requires activation of the small GTPases
Rac1 and Cdc42