We have a suspicion that you are an automated web bot software, not a real user. To keep our site fast for other users, we have slowed down this page. The slowdown will gradually disappear. If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu. Also note that all data for hgGeneGraph can be obtained through our public MySQL server and all our software source code is available and can be installed locally onto your own computer. If you are unsure how to use these resources, do not hesitate to contact us.
UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to TLR2

TLR1 — TLR2

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Krutzik et al., Nat Med 2003 (Leprosy) : In addition, interferon (IFN)-gamma and granulocyte-macrophage colony stimulating factor ( GM-CSF ) enhanced TLR1 expression in monocytes and dendritic cells, respectively, whereas IL-4 downregulated TLR2 expression
Oshikawa et al., Biochem Biophys Res Commun 2003 (Lung Diseases) : The results demonstrated three patterns of gene expression : the TLR2 and myeloid differentiation factor 88 ( MyD88 ) gene expressions were induced in AM in response to lipopolysaccharide (LPS), interleukin (IL)-1beta, or tumor necrosis factor-alpha or in the lung tissue of an LPS induced acute lung injury model ; the gene expressions of TLR1 , -3, -6, CD14, and MD2 were unchanged ; and the TLR4 and TLR5 gene expressions were downregulated in AM following inflammatory stimuli
Massari et al., J Immunol 2006 : Together, these data provide new evidence that TLR2 recognizes PorB through direct binding, and that PorB induced cell activation is mediated by a TLR2/TLR1 complex
Wu et al., Int J Immunogenet 2008 : As an important member of TLRs, TLR1 is involved in the recognition of triacylated lipoproteins and mycobacterial products by binding to TLR2 to form a heterodimer ... As an important member of TLRs, TLR1 is involved in the recognition of triacylated lipoproteins and mycobacterial products by binding to TLR2 to form a heterodimer
Aravalli et al., Journal of neuroinflammation 2008 (Histoplasmosis) : Furthermore, Yps3p induced TLR2 signaling was suppressed by vaccinia virus encoded TLR inhibitors
Regueiro et al., Infect Immun 2009 : We showed that Klebsiella induced TLR2 and TLR4 upregulation was dependent on TLR activation
So et al., Glia 2009 (Cardiovirus Infections) : More importantly, TLR3 was required for TMEV induced early TLR2 upregulation in primary astrocytes leading to the production of TLR2 dependent cytokines such as IL-6
Chamorro et al., J Immunol 2009 : TLR triggering on tolerogenic dendritic cells results in TLR2 up-regulation and a reduced proinflammatory immune program
Bayas et al., Clin Exp Immunol 2009 (Bacterial Infections...) : In peripheral blood mononuclear cells, TLR-9 stimulation with type A CpG ODN resulted in a higher expression of TLR-1 , -2, -4, -5 and -8 in MS patients ( n = 7 ) compared with healthy controls ( n = 11 )
Messlik et al., J Proteome Res 2009 (Chronic Disease...) : The aim of this study was to characterize the role of TLR2 or TLR4 deficiency in epithelial cell stress responses under noninflamed and inflamed conditions using TLR-deficient mice and TLR ( -/- ) cross bred IL-10-deficient mice as a model for genetically driven experimental colitis
Goethals et al., Glia 2010 (Wallerian Degeneration) : Upon axotomy, TLR1 becomes strongly induced , while most other TLR expression levels remain unaffected
Yang et al., Bing Du Xue Bao 2011 (Marek Disease...) : By comparing the TLRs transcription between YL040920 and CVI988/Rispens infected microglia, it was suggested that vvMDV YL040920 might induce more TLR15 transcript than the attenuated vaccine strain CVI988/Rispens ( P < or = 0.01/0.001 ), while CVI988/Rispens induced more TLR1LB transcript than YL040920 ( P < or = 0.001 )
Stridh et al., Journal of neuroinflammation 2011 (Hypoxia-Ischemia, Brain) : In contrast, TLR-2 was constitutively expressed in the brain and TLR-2 deficiency reduced HI injury
Kim et al., FEMS Microbiol Lett 2012 (Inflammation) : L. plantarum genomic DNA mediated inhibition of signaling pathway and tumor necrosis factor-alpha was accompanied by the suppression of toll-like receptor (TLR) 2 , TLR4, and TLR9 and the induction of interleukin-1 receptor associated kinase M, a negative regulator of TLR
Jia et al., Shanghai Kou Qiang Yi Xue 2011 : CD14, TLR4 receptors are involved in P.e-LPS effect and CD14, TLR2 and TLR4 receptors are involved in P.g-LPS effect in mouse osteoblast
Kumar et al., PloS one 2012 (Infection...) : Moreover, stimulation of the Muller glia with TLR 2 , 3, 4, 5, 7 and 9 agonists resulted in an increased TLR expression as assayed by Western blot and flow cytometry
Wang et al., PloS one 2012 (Cell Transformation, Neoplastic...) : TLR2 : TLR6 complexes mediate the effect of NF-?B inactivation by CDA-2
Feriotti et al., PloS one 2013 (Disease Susceptibility...) : Mannan or P. brasiliensis induced decreased expression of MR and TLR2 on A/J macrophages, whereas CR3, TLR4 and TLR2 were reduced on B10.A cells