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CDKN1A — PRKAA1

Text-mined interactions from Literome

Zhuang et al., Journal of molecular signaling 2008 : Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK , downregulation of cyclin D1, and requires p27Kip1 or p21Cip1
Yang et al., Cancer Res 2010 (Digestive System Neoplasms) : Atorvastatin induced AMPK activation could induce p21 expression, which was also positively correlated with beclin-1 expression in CRC patients ... In summary, activation of AMPK by atorvastatin enhances p21 expression and ER stress response, leading to autophagy, which promotes survival of cancer cells
Zhang et al., J Biol Chem 2010 (Glioblastoma) : In further studies, we found that activation of AMPK is involved in TMZ induced p53 activation and subsequent p21 , Noxa, and Bax up-regulation
Chen et al., Bioorg Med Chem 2012 : Activation of AMPK by these EGCG analogs resulted in inhibition of cell proliferation, up-regulation of the cyclin dependent kinase inhibitor p21 , down-regulation of mTOR pathway, and suppression of stem cell population in human breast cancer cells