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MYLIP — STAT3

Text-mined interactions from Literome

Cascio et al., J Cell Physiol 2010 (Breast Neoplasms) : In summary, this report demonstrates, for the first time, that the VEGF expression in breast cancer cells is mediated by HIF-1 and STAT3 in a miR-20b dependent manner
Iliopoulos et al., Mol Cell 2010 (Adenocarcinoma...) : STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer ... STAT3 , a transcription factor activated by IL-6, directly activates miR-21 and miR-181b-1
Yang et al., Cancer Res 2010 (Prostatic Neoplasms) : STAT3 ablation abrogated IFN induction of miR-21, confirming the important role of STAT3 in regulating miR-21
Haghikia et al., Eur Heart J 2011 (Heart Failure) : Lentiviral shRNA mediated STAT3-knock-down in neonatal rat CMs markedly increased miR-199a promoter activity and miR-199a levels indicative of a suppressive effect of STAT3 on miR-199a transcription
Dai et al., Cancer Res 2011 (Lung Neoplasms) : Together, these results indicated that STAT3 mediated overexpression of miR-17 blocked BIM expression and caused resistance to AZD6244
Bourguignon et al., Oncogene 2012 (Carcinoma, Squamous Cell...) : Further analyses reveal that miR-21 is controlled by an upstream promoter containing Stat-3 binding site ( s ), while chromatin immunoprecipitation assays demonstrate that stimulation of miR-21 expression by HA/CD44 signaling is Nanog/Stat-3 dependent in HNSCC cells
Zhang et al., Hepatology 2011 (Carcinoma, Hepatocellular...) : In addition, miR-637 overexpression negatively regulated Stat3 phosphorylation by suppressing autocrine leukemia inhibitory factor (LIF) expression and exogenous LIF triggered Stat3 activation and rescued cell growth in these cells
Kohanbash et al., Semin Cancer Biol 2012 (Neoplasms) : There is a growing body of evidence demonstrating that STAT3 directly activates miR-21 , one of miRs that promote cancer cell survival and proliferation
Wang et al., Hepatology 2012 (Carcinoma, Hepatocellular...) : Finally, this study showed that the activation of interleukin (IL)-6-Stat3 signaling caused the up-regulation of miR-23a expression in HCC ... CONCLUSION : Based on these data, we conclude that gluconeogenesis is severely compromised in HCC by IL6-Stat3 mediated activation of miR-23a , which directly targets PGC-1a and G6PC, leading to decreased glucose production
Bornachea et al., Scientific reports 2012 (Carcinoma, Squamous Cell...) : The augmented expression of miR-21 , mediated by active mTOR and Stat3 signalling, conferred increased invasive properties to mouse keratinocytes in vitro and in vivo, whereas blockade of miR-21 in a metastatic spindle cell line inhibits metastasis development
Wang et al., CNS Neurosci Ther 2012 (Brain Neoplasms...) : Further, reduction of miR-21 decreased the expression of human telomerase reverse transcriptase ( hTERT ) and repressed STAT3 expression and STAT3 phosphorylation
He et al., Cell Death Differ 2013 (Leukemia, Myeloid, Acute) : More intriguingly, miR-17 and miR-20a directly inhibit the p21 and STAT3 ( signal transducer and activator of transcription 3 ) expression, both of which can reverse miR-17/miR-20a mediated abrogation of HIF-1a induced differentiation
Noguchi et al., Cell death & disease 2013 (Urinary Bladder Neoplasms) : Furthermore, exogenous miR-145 or socs7 silencing promoted nuclear translocation of STAT3
Zhang et al., Brain Res 2013 (Body Weight...) : Regulation of STAT3 by miR-106a is linked to cognitive impairment in ovariectomized mice ... STAT3 and phospho-STAT3 protein expression was upregulated or downregulated by a miR-106a inhibitor or miR-106a mimic, respectively, indicating that miR-106a negatively regulates STAT3 ... This study suggests that miR-106a negatively regulates STAT3 activation, and also that miR-106a may provide a marker of onset or potential therapeutic target for cognitive disturbances
Sawant et al., Mol Immunol 2013 (Inflammation) : Bcl6 represses and Stat3 activates miR-21 transcription through a Stat3 binding element in the promoter, indicating opposing regulation of miR-21 by the two transcription factors via the same DNA site
Elsarraj et al., J Cell Sci 2013 : Therefore, we conclude that during pregnancy miR146b is involved in luminal alveolar progenitor cell maintenance, at least partially, by regulating STAT3ß
Escobar et al., Invest Ophthalmol Vis Sci 2013 (Autoimmune Diseases...) : STAT3 activates miR-155 in Th17 cells and acts in concert to promote experimental autoimmune uveitis ... We used a combination of genomic and genetic tools to provide the first evidence that STAT3 binds directly to the miR-155 locus and that STAT3 is required for miR-155 expression ... Furthermore, STAT3 dependent increase in miR-155 expression in vivo correlated temporally with onset of EAU, and miR-155 ( -/- ) or CD4-STAT3KO mice did not suffer EAU ... We show here for the first time to our knowledge that STAT3 regulates miR-155 expression in Th17 cells
Rozovski et al., Molecular cancer 2013 (Leukemia, Lymphocytic, Chronic, B-Cell) : Because miR levels are deregulated in chronic lymphocytic leukemia ( CLL ) and signal transducer and activator of transcription ( STAT ) -3 is constitutively activated in CLL, we sought to determine whether STAT3 affects the transcription of miR genes in CLL cells
Li et al., PloS one 2013 : Given these findings, we hypothesized that STAT3 induces miR-155 ... Together, these results suggest that STAT3 activates miR-155 in CLL cells
Lin et al., Br J Cancer 2013 (Lung Neoplasms...) : STAT3 upregulates miR-92a to inhibit RECK expression and to promote invasiveness of lung cancer cells ... Anti-miR-92a attenuates MMP activity, migration and invasion of H1299 cells and STAT3 overexpressing H460 cells, suggesting miR-92a is critical for STAT3 induced invasiveness.Conclusion : The STAT3 induced miR-92a promotes cancer invasion by suppressing RECK and targeting of the STAT3/miR-92a axis may be helpful for cancer treatment