UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

HCK — IL6

Pathways - manually collected, often from reviews:

OpenBEL Selventa BEL large corpus: HCK → IL6 (increases, IL6 Activity) Podar et al., J Biol Chem 2004
Evidence: We further demonstrate that these events are Src family tyrosine kinase-dependent and specifically identify the role of hematopoietic cell kinase (Hck) as a new Gab family adapter protein kinase. Conversely, inhibition of Src family tyrosine kinases by the pyrazolopyrimidine PP2, as in kinase-inactive Hck mutants, significantly reduces IL-6-triggered activation of extracellular signal-regulated kinase and AKT-1, leading to significant reduction of multiple myeloma cell proliferation and survival...
NCI Pathway Database IL6-mediated signaling events: GRB2/SOS1/GAB family complex (GRB2-SOS1-GAB1_GAB2) → IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/Hck complex (IL6-IL6R-IL6ST-JAK1-LMO4-HCK) (modification, collaborate)
Kim et al., Mol Cell Biol 1999, Podar et al., J Biol Chem 2004
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL6-mediated signaling events: SHP2 (PTPN11) → IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/Hck complex (IL6-IL6R-IL6ST-JAK1-LMO4-HCK) (modification, collaborate)
Kim et al., Mol Cell Biol 1999, Podar et al., J Biol Chem 2004
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → Hck (HCK) (modification, collaborate) Schaeffer et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/Hck complex (IL6-IL6R-IL6ST-JAK1-LMO4-HCK) (modification, collaborate)
Schaeffer et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL6-mediated signaling events: Hck (HCK) → IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/Hck complex (IL6-IL6R-IL6ST-JAK1-LMO4-HCK) (modification, collaborate)
Schaeffer et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction

Text-mined interactions from Literome

Schaeffer et al., Mol Cell Biol 2001 : Interleukin-6 (IL-6) induces the activation of the Src family kinase Hck , which is associated with the IL-6 receptor beta-chain, gp130
Hausherr et al., Oncogene 2007 (Multiple Myeloma) : IL-6-treatment of INA-6 cells induced the kinase activities of Fyn, Lyn and Hck , but not Src, and the IL-6 induced SFK activities were inhibited by peptide 18AD
Hallek et al., Exp Hematol 1997 : IL-6 induced the activation and tyrosine phosphorylation of p59Fyn, p56/59Hck , and p56Lyn ... Together, these results show for the first time that several Src kinases may become activated by IL-6 ( p59Fyn, p56/59Hck , and p56Lyn ) and associate with gp130 ( p56/59Hck and p56Lyn )