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EPHB2 — TNF

Text-mined interactions from Literome

Murakami-Mori et al., J Immunol 1999 (Acquired Immunodeficiency Syndrome...) : Implication of TNF receptor-I mediated extracellular signal regulated kinases 1 and 2 ( ERK1/2 ) activation in growth of AIDS associated Kaposi 's sarcoma cells : a possible role of a novel death domain protein MADD in TNF-alpha induced ERK1/2 activation in Kaposi 's sarcoma cells ... We found that extracellular signal regulated kinases 1 and 2 ( ERK1/2 ) in KS cells were significantly activated by TNF-alpha through tyrosine/threonine phosphorylation ... Using neutralizing anti-TNFR-I and TNFR-II mAbs, we have now obtained evidence that TNF-alpha induced KS cell growth and ERK1/2 activation are mediated exclusively by TNFR-I, not by TNFR-II
Sato et al., J Immunol 1999 : TNF-alpha induced tyrosine phosphorylation and enzymatic activation of ERK2 , SAPK/JNK, and p38mapk, whereas IL-10 did not induce these events
Yazlovitskaya et al., Mol Carcinog 1999 (Adenocarcinoma...) : However, inhibition of TNF alpha induced ERK1/2 activity by the MAP/ERK kinase 1 inhibitor PD 98059 resulted in 60 % inhibition of cell growth in TNF alpha treated UCI 101 cells ... Thus, the inhibition of TNF alpha induced ERK1/2 activity was associated with induction of apoptosis in the TNF alpha-resistant cell line UCI 101 ... Inhibition of TNF alpha induced ERK1/2 activity was accompanied by a subsequent transient increase in TNF alpha induced JNK1 activity
Leonard et al., Kidney Int 1999 (MAP Kinase Signaling System) : PD98059 decreased both basal and TNF-alpha stimulated phosphorylation of ERK1,2
Wang et al., Hypertension 1999 (MAP Kinase Signaling System) : Tumor necrosis factor-alpha (TNF-alpha) alone can induce extracellular signal regulated kinase ( ERK ), p38 MAPK, and c-Jun N-terminal kinase activity in a rapid and transient manner, whereas interferon-gamma (IFN-gamma) can induce only ERK
Hoshi et al., J Biol Chem 2000 : The phosphorylation of ERK1/2 was rapidly induced by TRAP and bFGF but not by TNF-alpha
Maruoka et al., Am J Respir Crit Care Med 2000 : TNF-alpha induced p38 MAP kinase and Erk phosphorylation, but neither SB 203580 nor PD 98059 inhibited RANTES production
Goetze et al., J Biol Chem 2000 : In contrast, TNFalpha transiently suppressed insulin induced ERK1/2 activation
Lüschen et al., Biochem Biophys Res Commun 2000 : Activation of ERK1/2 and cPLA(2) by the p55 TNF receptor occurs independently of FAN ... Analysis of embryonal fibroblasts from FAN knockout mice revealed that TNF induced activation of both ERK and cPLA(2) occurs without involvement of FAN ... Furthermore, we provide evidence that the TNF dependent activation of ERK and cPLA(2) requires the intact death domain of TNF-R55
De et al., J Immunol 2000 : Although exogenous hsp27 stimulation activated all three monocyte mitogen activated protein kinase pathways ( extracellular signal related kinase ( ERK ) 1/2, c-Jun N-terminal kinase, and p38 ), only p38 activation was sustained and required for hsp27 induction of monocyte IL-10, while both ERK 1/2 and p38 activation were required for induction of TNF-alpha when using the p38 inhibitor SB203580 or the ERK inhibitor PD98059
Tudan et al., J Immunol 2000 (MAP Kinase Signaling System) : CPPD crystals were observed to induce a robust and transient activation of ERK1 , ERK2, and Akt, whereas TNF-alpha produced only a modest and delayed activation of Akt
Rutault et al., J Biol Chem 2001 : We have studied the role of ERK and p38 mitogen activated protein ( MAP ) kinase in controlling TNF-alpha mRNA levels in differentiated THP-1 cells and in freshly purified human monocytes
Mechtcheriakova et al., FASEB J 2001 (MAP Kinase Signaling System) : TNF-alpha mediated activation of MEK/ERK and EGR-1 can be blocked by adenoviral expression of a dominant negative mutant of IKK2, whereas the VEGF signaling pathway is unaffected
Yan et al., Cancer Res 2001 (MAP Kinase Signaling System) : To determine the role of KSR in TNF-alpha induced ERK1/ERK2 activation, we studied young adult mouse colon cells expressing a dominant negative, kinase-inactive ( ki ) KSR ... We report that TNF-alpha , a cell-permeable ceramide, and sphingomyelinase stimulate ERK1/ERK2 activation and increase the phosphoserine content of KSR, which are inhibited by kiKSR expression in intact cells ... We therefore conclude that KSR is an essential upstream regulator of TNF-alpha stimulated ERK1/ERK2 activation, most likely mediated via direct phosphorylation of Raf-1
Tran et al., J Biol Chem 2001 : Activation of the FasR, TNF-R1 , and TRAIL-R, respectively, rapidly induced subsequent ERK1/2 activation, an event independent from caspase activity
Surapisitchat et al., Proc Natl Acad Sci U S A 2001 (MAP Kinase Signaling System) : Fluid shear stress inhibits TNF-alpha activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells : Inhibitory crosstalk among MAPK family members ... TNF-alpha or IL-1 alone activated ERK1/2 , p38, and JNK maximally at 15 min in HUVEC
Nosaka et al., Biochem Biophys Res Commun 2001 (Fibrosarcoma) : The PI3K inhibitor LY294002 significantly inhibited TNFalpha activation of Rac as well as Erk and abolished that of the PI3K target Akt, without showing any inhibitory effects on JNK and p38 activation ... Furthermore, TNFalpha activation of Erk was abolished by a dominant negative Rac mutant, Rac17N, or by an activated Rac mutant, Rac12V
Barbin et al., Neurochem Res 2001 : The TNFalpha induced activation of ERK1/2 was specifically prevented by compound PD 98059 a specific inhibitor of the MAP kinase kinase MEK1/2
Yi et al., Int Immunol 2001 : Both extracellular receptor kinase (ERK) and p38 can regulate TNF-alpha gene transcription induced by CpG DNA
Lee et al., J Biol Chem 2001 : PD98059, a specific inhibitor of the ERK activating kinase MEK-1, abolished the TNF-alpha induced ERK phosphorylation and osteoclast survival, and in these responses the involvement of Grb2 and ceramide was observed
Kishore et al., Am J Physiol Gastrointest Liver Physiol 2002 (Alcoholism) : ERK1/2 and Egr-1 contribute to increased TNF-alpha production in rat Kupffer cells after chronic ethanol feeding ... Activation of ERK1/2 was required for maximal increases in TNF-alpha and IL-1beta mRNA and was associated with increased binding of early growth response-1 (Egr-1) to the TNF-alpha promoter after ethanol feeding ... Together, these data suggest that enhanced activation of ERK1/2 and Egr-1 contributes to increased TNF-alpha production after chronic ethanol feeding
Tse et al., J Immunol 2002 (MAP Kinase Signaling System) : In contrast, SmO induction of the ERK pathway was increased compared with the SmT morphotype, and inhibition of ERK resulted in decreased TNF-alpha synthesis and enhanced SmO growth
Yanagawa et al., J Leukoc Biol 2002 : These findings suggest that TNF-alpha induced ERK activation negatively controls maturation and IL-12 production in murine DC
Berk et al., Ann N Y Acad Sci 2001 (Arteriosclerosis...) : TNF ( 10 ng/ml ) alone activated both ERK1/2 and JNK maximally at 15 minutes in human umbilical vein EC ( HUVEC )
Haddad et al., Br J Pharmacol 2002 : MAPK ( ERK ) blockade ( PD-98059 ) attenuated TNF-alpha secretion, an effect synergistically amplified in the presence of SB-203580
Zhang et al., Chin J Traumatol 2001 (Endotoxemia...) : To study the rule of ERK1/2 activity and regulative effect of ERK1/2 pathway on the production of pro-inflammatory cytokine TNFalpha in mice Kupffer cells ( mKC ) induced by LPS, and to exploring novel methods to prevent and treat clinical patients of endotoxemia
Monier et al., J Infect Dis 2002 : ERK pathway inhibitors significantly reduced TNF secretion when added at the same time as pneumococcal challenge, and inhibitors of both ERK and p38 pathways reduced TNF secretion when added to the macrophages 1 h before stimulation
Weber et al., J Immunol 2002 (MAP Kinase Signaling System) : These findings were supported by functional data demonstrating that CQ and PD98059 interfered with TNF expression in several human and murine cell types while neither inhibitor blocked TNF production in murine RAW264.7 macrophages, a cell line that does not require MEK-ERK signaling for TNF production
Shi et al., Am J Physiol Cell Physiol 2002 : However, the role of ERK1/2 activation in mediating LPS stimulated TNF-alpha production is not well understood
Reunanen et al., J Biol Chem 2002 : Tumor necrosis factor-alpha rapidly and transiently activated ERK1/2 and JNK in fibroblasts, whereas the activation of p38 MAPK was more persistent
Zhang et al., Diabetes 2002 (MAP Kinase Signaling System) : TNF-alpha activated ERK and increased lipolysis ; these effects were inhibited by two specific MEK inhibitors, PD98059 and U0126
Trajkovic et al., Infect Immun 2002 : The activation of protein tyrosine kinases ( PTK ) and the serine/threonine kinases p38 MAPK and ERK was apparently required for MTSA-10 induction of TNF-alpha and NO release, as revealed by specific kinase inhibitors
Choi et al., Kidney Int 2003 : Western blotting showed that statins inhibited TNF-alpha induced ERK phosphorylation in a dose dependent fashion, but had no effect on p38
Chung et al., Exp Mol Med 2002 : TNF-alpha does not induce phosphorylation of ERK1/ERK2 and S727 in ECV304 and smooth muscle cells
Park et al., Cytokine 2002 : Together, the p43 induced TNF production was controlled by NFkB, p38 MAPK, and ERK that is dependent on the activities of PLC and PKC
Murr et al., J Gastrointest Surg 2003 (Acute Disease...) : It was concluded that pretranscriptional regulation of TNF gene expression in Kupffer cells follows an orderly activation of p38-MAPK, ERK1/2 , and SAPK/JNK that may not converge on NF-kappaB
Hide et al., Nihon Yakurigaku Zasshi 2003 (Hypersensitivity...) : ERK and JNK are also involved in ATP induced TNF transcription, while p38 regulates the transport of TNF mRNA from the nucleus to the cytosol
Yoshizumi et al., J Pharmacol Sci 2003 (Arteriosclerosis) : TNF-alpha activated ERK1/2 , JNK, and p38 maximally at 15 min in HUVEC
Devin et al., EMBO Rep 2003 (MAP Kinase Signaling System) : We found that TNF induced activation of ERK , p38 and JNK is decreased in Rip ( -/- ) cells
Song et al., J Clin Immunol 2003 (Tuberculosis) : The role of mitogen activated protein kinase ( MAPK ) pathways in the secretion of tumor necrosis factor (TNF)-alpha, interleukin (IL)-10, IL-8, and monocyte chemotactic protein-1 (MCP-1) was investigated in human monocytes that were infected with Mycobacterium tuberculosis H37Rv. Analysis of extracellular signal regulated kinases 1 and 2 ( ERK1/2 ) and p38 kinase showed rapid phosphorylation of both subfamilies in response to M. tuberculosis H37Rv. Using highly specific inhibitors of p38 ( SB203580 ) and of MAPK kinase-1 ( U0126 and PD98059 ), we found that both p38 and ERK were essential for M. tuberculosis H37Rv induced TNF-alpha production, whereas activation of the p38 pathway, but not that of ERK, was essential for M. tuberculosis H37Rv induced IL-10 production
Comalada et al., Am J Physiol Cell Physiol 2003 : JNK mainly regulates TNF-alpha transcription and apoptosis, whereas ERK and p38 contribute to the regulation of TNF-alpha production, probably through posttranscriptional mechanisms
Jana et al., J Neurochem 2003 : Interestingly, PD98059, an inhibitor of ERK , inhibited p40 induced expression of TNF-alpha through the inhibition of C/EBPbeta, but not that of NF-kappaB, whereas SB203580, an inhibitor of p38 MAPK, inhibited p40 induced expression of TNF-alpha through the inhibition of both NF-kappaB and C/EBPbeta
Yamaguchi et al., Hypertens Res 2003 (Arteriosclerosis...) : TNF-alpha had no effect on either IRS-1 phosphorylation or ERK in VSMC
Souza et al., J Cell Biochem 2003 : We demonstrated that U0126 or PD98059 blocked TNF-alpha induced ERK activity and decreased TNF-alpha induced lipolysis by 65 or 76 % respectively ... Pretreatment of adipocytes with these agents almost totally blocked TNF-alpha induced ERK activation and reduced lipolysis by greater than 90 %
Nakayama et al., Biochem Biophys Res Commun 2003 (MAP Kinase Signaling System) : We demonstrated in DC2.4 dendritic cells that ERK regulates tyrosine phosphorylation of phosphatidyl-inositol-3-kinase (PI3-K) and the production of TNF-alpha
Kwon et al., Arch Pharm Res 2003 : Salicylate inhibited the IL-1beta and TNF-alpha induced COX-2 expressions, regulated the activation of ERK , IKK and IkappaB degradation, and the subsequent activation of NF-kappaB, in neonatal rat ventricular cardiomyocytes
Kutsuna et al., Am J Physiol Cell Physiol 2004 : These findings suggest that TNF , GM-CSF, and G-CSF induce actin depolymerization and morphological changes through activation of ERK and/or p38 MAPK and that cytokine induced actin reorganization may be partly responsible for the inhibitory effect of these cytokines on neutrophil chemotaxis
Bhattacharya et al., Am J Physiol Gastrointest Liver Physiol 2004 : Pretreatment of polyamine depleted IEC-6 cells with a cell membrane-permeable MEK1/2 inhibitor, U-0126, significantly inhibited TNF-alpha/CHX induced ERK phosphorylation and significantly increased DNA fragmentation, JNK activity, and caspase-3 activity in response to TNF-alpha/CHX
Xie et al., J Immunol 2003 : Furthermore, LPS up-regulated the secretion of IL-1beta, IL-6, IL-8, IL-10, and TNF-alpha ; reduced Ag presentation capacity ; and inhibited phosphorylation of ERK , but activated p38, leading to a reduced NF-kappaB activity in treated cells
Suzuki et al., J Neurosci 2004 : Together, these findings indicate that both ERK and JNK are involved in the regulation of TNF mRNA expression, that p38 is involved in the nucleocytoplasmic transport of TNF mRNA, and that a PTK ( protein tyrosine kinase ), possibly a member of the src family, acts downstream of the P2X7 receptor to activate JNK and p38
Moon et al., J Cell Physiol 2004 : Finally, the transient transfection of HASMC with dominant negative Ras ( RasN17 ) suppressed TNF-alpha induced ERK activity, MMP-9 production, and promoter activity
Kesavan et al., J Cell Physiol 2004 : Bacterial lipopolysaccharide (LPS) and TNFalpha neither activate ERK5 nor require MEKK2 for JNK activation, demonstrating specificity of MEKK2 in FGF-2 receptor signaling and control of cytokine gene expression
Ait-Ali et al., Mol Endocrinol 2004 : Stimulatory effects of TNF-alpha on neuropeptide gene expression and release appeared to be mediated through the type 2 TNF-alpha receptor, and required activation of ERK 1/2 and p38, but not Janus kinase, MAPKs
Lee et al., J Pharm Pharmacol 2004 (Anaphylaxis) : A. semen also inhibited the expression of TNF-alpha and the activation of mitogen activated protein kinase, ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells, as indicated by the suppression of the activating phosphorylation of ERK1/2
Kim et al., Int Immunopharmacol 2004 : Bis-indolylmaleimide, an inhibitor of protein kinase C, partially blocked the up-regulation of CD83 and ERK phosphorylation induced by PA and TNF-alpha ... These results suggest that PA and TNF-alpha induce the up-regulation of CD83 and that their action is regulated by ERK and JNK
Lee et al., J Ethnopharmacol 2004 (Anaphylaxis) : Chrysanthemi sibirici herba also inhibited the expression of TNF-alpha and the activation of the MAP kinase, ERK1/2 , which is critical for the production of inflammatory cytokines in mast cells, as indicated by the suppression of activating phosphorylation of ERK1/2
Yoshino et al., Am J Reprod Immunol 2004 (Endometriosis) : IL-1beta, TNFalpha and H ( 2 ) O ( 2 ) stimulated the phosphorylation of ERK , p38 and JNK, while the total amounts of proteins of the respective MAPKs were virtually the same compared with those in the unstimulated controls
Boislève et al., Toxicology 2005 (MAP Kinase Signaling System) : Our results also suggest that activation of p38 MAPK by TNF-alpha could partially suppress ERK activation and abrogates the inhibitory effect of ERK on DC maturation
Kim et al., Int Immunopharmacol 2005 : In addition, luteolin inhibited TNF-alpha induced phosphorylation of p38 MAPK and extracellular regulated kinases (ERK) , IkappaB degradation, and NF-kappaB activation
Goral et al., J Immunol 2005 (Inflammation) : However, inhibitors of serine/threonine protein phosphatase type 1 and type 2A significantly increased IL-6 and TNF-alpha levels, and prolonged activation of p38 and ERK1/2 when triggered by TLR4 and TLR9 ligands
el-Naggar et al., Kobe J Med Sci 2004 : The anabolic effect of TNF-alpha was mediated at least in part by mitogen activated protein kinase ( MAPK ), especially by an extracellular regulated kinases (ERK)
van Vliet et al., Nat Immunol 2005 (MAP Kinase Signaling System) : Selective regulation of tumor necrosis factor induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase
Li et al., Mol Cell Biol 2005 : Knockdown of TRAF4 expression using siRNA had no effect on p47phox phosphorylation or binding to p22phox but inhibited TNF-alpha induced ERK1/2 activation ... In coronary microvascular EC from p47phox-/- mice, TNF-alpha induced NADPH oxidase activation, ERK1/2 activation , and cell surface intercellular adhesion molecule 1 ( ICAM-1 ) expression were all inhibited
Lecureur et al., FEBS Lett 2005 : ERK dependent induction of TNFalpha expression by the environmental contaminant benzo ( a ) pyrene in primary human macrophages
Tsang et al., J Leukoc Biol 2005 (Inflammation...) : Results indicated that SCF activated ERK , and TNF-alpha activated the p38 MAPK and NF-kappaB pathway ... Therefore, SCF and TNF-alpha acted through ERK and the NF-kappaB pathway to regulate the ICAM-1 expression and elicited the synergistic effect
Li et al., J Biol Chem 2005 (Arteriosclerosis...) : The increases in TNF-alpha and IL-6 mRNA and protein were mediated by FC-induced activation of the IkappaB kinase/NF-kappaB pathway as well as activation of MKK3/p38, Erk1/2 , and JNK1/2 mitogen activated protein kinases ( MAPK )
Kang et al., Int J Mol Med 2005 : In addition, GA inhibited TNF-alpha induced phosphorylation of p38 MAPK and extracellular regulated kinases (ERK) , I kappa B alpha degradation, and NF-kappa B activation
Yamada et al., J Urol 2005 (Urinary Bladder Neoplasms) : TNF-alpha also activated NF-kappaB, AP-1 and ERK1/2
Lüschen et al., Exp Cell Res 2005 : The Fas associated death domain protein/caspase-8/c-FLIP signaling pathway is involved in TNF induced activation of ERK ... Therefore, we have analyzed TNF induced ERK activation in various human and murine cell lines and show that it occurs in a cell-type-specific manner ... In addition, we provide evidence for the involvement of the signaling components Fas associated death domain protein ( FADD ), caspase-8, and c-FLIP in the pathway activating ERK in response to TNF ... ( II ) TNF induced ERK activation is strongly diminished in the absence of FADD ... Interestingly, the enzymatic function of caspase-8 is not required for TNF induced ERK activation
Theiss et al., J Biol Chem 2005 (Fibrosis...) : TNFalpha also activated ERK1/2
Jung et al., J Clin Immunol 2005 (MAP Kinase Signaling System...) : The analysis of cytokine production using specific inhibitors of the MAPK pathway revealed that both p38 and ERK activation are essential for PPD induced TNF-alpha production, whereas p38, but not ERK, activation is essential for IL-10 secretion
Kobayashi et al., Exp Dermatol 2005 : We show ( i ) UV induced up-regulation of TNF-alpha mRNA and protein expression in keratinocytes ; ( ii ) cells treated with KTI before UV irradiation showed a significantly lower accumulation of TNF-alpha protein in a dose dependent manner and a reduced UV-induced up-regulation of TNF-alpha mRNA expression ; ( iii ) KTI inhibited the induction of TNF-alpha target molecules interleukin-1beta (IL-1beta) and IL-6 proteins ; ( iv ) UV irradiation transiently activated c-Jun N-terminal kinase (JNK) and Akt signaling but only weakly activated extracellular signal regulated kinase ( ERK ) and p38 ; ( v ) KTI specifically inhibited UV-induced activation of ERK , JNK, and p38, but not Akt ; ( vi ) treatment of cells with SP600125, a pharmacological inhibitor of JNK, predominantly suppressed UV-induced up-regulation of TNF-alpha expression ; and ( vii ) KTI did not enhance suppression of UV-induced JNK phosphorylation by SP600125
Lee et al., Infect Immun 2005 : This correlated with the requirement for ERK1/2 in TNF-alpha but not NOS2 promoter activity ... Our data indicate that the increased Ets/Elk and NF-kappaB promoter activities associated with M. smegmatis infected macrophages are responsible, at least in part, for the increased TNF-alpha and NOS2 production observed in these infected cells and that ERK1/2 is required for Ets/Elk activity and full TNF-alpha production
Görtz et al., Arthritis Res Ther 2005 (Arthritis...) : In vivo, overexpression of TNF induced activation of p38MAPKalpha and ERK in the synovial membrane, whereas activation of JNK was less pronounced and rarely observed on immunohistochemical analysis ... These data indicate that TNF preferentially activates p38MAPKalpha and ERK in synovial membrane exposed to TNF
Gomez et al., J Immunol 2005 (Arthritis, Rheumatoid...) : PGE2 also blocked IL-1beta/TNF-alpha stimulated ERK activation, and the ERK inhibitor, PD98059, mimicked PGE2 in blocking p65, but enhancing p50 nuclear translocation, suggesting that the effects of PGE2 on p65 and p50 are mediated via effects on ERK
Masamune et al., J Cell Biochem 2006 : Curcumin inhibited interleukin-1beta- and TNF-alpha induced activation of activator protein-1 (AP-1) and mitogen activated protein ( MAP ) kinases ( ERK , c-Jun N-terminal kinase (JNK), and p38 MAP kinase ), but not of nuclear factor-kappaB (NF-kappaB)
Bhatnagar et al., Cell Microbiol 2006 (Mycobacterium avium-intracellulare Infection) : Interestingly, TNF-alpha secretion by macrophages infected with SmO or SmT 2151 was dependent on p38, ERK1/2 and NF-kappaB while TNF-alpha secretion by Rg 2151 infected macrophages was dependent on NF-kappaB but not the MAPKs
Huang et al., Acta Med Okayama 2005 (Fibrosarcoma) : TNFalpha induced p38 and ERK activation, whereas oridonin triggered only ERK activation
Zhao et al., Cell Immunol 2005 (MAP Kinase Signaling System) : Although gAd partially increased cAMP concentration and PKA activity, it directly reduced leptin induced ERK1/2 and p38 MAPK phosphorylation thus inhibiting TNF-alpha production
Méndez-Samperio et al., J Infect 2006 (Calcium Signaling...) : We now define distinct signaling pathways that regulate induction of TNF-alpha and activation of ERK1/2 by intracellular signaling mechanisms during M. bovis infection
Ahmed et al., Am J Physiol Gastrointest Liver Physiol 2006 : TNF attenuated JAK2/STAT5 and ERK1/2 phosphorylation and IGF-I and Spi 2.1 mRNA expression following GH stimulation
Zhang et al., Free Radic Biol Med 2006 : These results suggest that notoginsenoside R1 inhibits TNF-alpha induced ERK activation and subsequent fibronectin overexpression and migration in HASMCs by suppressing NADPH oxidase mediated ROS generation and directly scavenging ROS
Granata et al., Eur J Immunol 2006 : sPLA ( 2 ) induced the phosphorylation of the MAPK p38 and ERK1/2 , and inhibition of these kinases by SB203580 and PD98059, respectively, reduced TNF-alpha and CXCL8 release
Jin et al., Am J Physiol Gastrointest Liver Physiol 2006 (MAP Kinase Signaling System) : Inhibition of Rac1 does not modulate TNF-alpha induced ERK1/2 and Akt activation
Page et al., Allergy 2006 (Asthma) : We found that selective activation of PAR-2 using the peptide SLIGKV augmented TNFalpha induced MMP-9 protein levels and increased ERK phosphorylation
Séguin et al., Matrix Biol 2006 (Disease Models, Animal...) : We demonstrate that in nucleus pulposus cells, the p38 and JNK pathways regulate induction of MMP-1 and -3 ; p38, JNK, and NF-kappaB regulate the induction of MMP-13 ; and ERK regulates the up-regulation of MT1-MMP mRNA in response to TNFalpha
Fushimi et al., J Cell Biochem 2007 (MAP Kinase Signaling System) : Exogenously added PGE ( 2 ) potently inhibited TNF-alpha induced both MMP-1 production and activation of ERK1/2
Fusello et al., J Immunol 2006 (Arthritis) : The MAPK ERK is required for LPS induced TNF production by macrophages
Radeff-Huang et al., J Biol Chem 2007 (Brain Neoplasms...) : ERK activation was also required for TNF-alpha stimulated DNA synthesis but likewise TNF-alpha induced ERK activation was not blocked by inhibition of SphK ... Additional studies demonstrated that TNF-alpha effects on DNA synthesis, ERK , and Akt phosphorylation are not mediated through cell surface Gi -coupled S1P receptors, because none of these responses were inhibited by pertussis toxin
Kilpatrick et al., J Leukoc Biol 2006 (MAP Kinase Signaling System) : The purpose of this study was to determine whether the MAPK, ERK1/2 , and p38 MAPK are involved in TNF antiapoptotic signaling and whether delta-PKC is a key regulator of MAPK activation by TNF ... In human neutrophils, TNF activated both p38 MAPK and ERK1/2 principally via TNFR-1 ... A specific delta-PKC antagonist, V1.1delta-PKC-Tat peptide, inhibited TNF mediated ERK1/2 activation, but not p38 MAPK
Kunisch et al., Ann Rheum Dis 2007 (Arthritis, Rheumatoid...) : In RA- and OA-SFB, TNFalpha induced phosphorylation of p38, ERK or JNK was exclusively mediated by TNF-R1
Zhan et al., J Cell Sci 2007 (Mechanotransduction, Cellular) : Disrupting TNF-alpha signaling by TNF-alpha neutralizing antibody or knocking out TNF-alpha receptors blocked stretch activation of p38, but not ERK1/2 , JNK or AKT
Windheim et al., Biochem J 2007 : We also show that MDP activates ERK1 ( extracellular-signal regulated kinase 1 ) /ERK2 and p38alpha MAPK in human peripheral-blood mononuclear cells and that the activity of both MAPKs and TAK1 are required for MDP induced signalling and production of IL-1beta and TNFalpha in these cells
Li et al., Endocrinology 2007 : TNF-alpha also potently stimulated the phosphorylation of ERK1/2 and AMPK ... Treatment with SB203580 decreased p38 MAPK phosphorylation back to the baseline and restored insulin sensitivity of IRS-1 tyrosine and Akt phosphorylation and eNOS activity in TNF-alpha treated bAECs without affecting TNF-alpha induced ERK1/2 and AMPK phosphorylation ... We conclude that in cultured bAECs, TNF-alpha induces insulin resistance in the phosphatidylinositol 3-kinase/Akt/eNOS pathway via a p38 MAPK dependent mechanism and enhances ERK1/2 and AMPK phosphorylation independent of the p38 MAPK pathway
Park et al., J Biol Chem 2007 : Inhibition of ERK1/2 with U0126 potently suppressed gAcrp stimulated Egr-1 promoter activity, as well as TNF-alpha promoter activity
Hong et al., BMC molecular biology 2007 : Functionally, transiently overexpressed Zfra sequestered NF-kappaB ( p65 ), WOX1, p53 and phospho-ERK ( extracellular signal activated kinase ) in the cytoplasm, and TNF or UV light could not effectively induce nuclear translocation of these proteins
Strle et al., J Neuroimmunol 2007 : This protection occurs without decreasing global activity of TNF receptors since IL-10 does not impair TNFalpha induced IL-6 synthesis or ERK1/2 phosphorylation
Koga et al., Am J Physiol Lung Cell Mol Physiol 2007 : Both U0126, an inhibitor of MEK1/2, and dominant negative ERK1 prevented TNF-alpha induced MUC1 promoter activation, and anti-TNFR1 antibody blocked TNF-alpha stimulated ERK1/2 activation
Deleault et al., Mol Immunol 2008 (MAP Kinase Signaling System) : To further characterize the control of TTP function, we examined the combinatorial effect of p38, ERK and JNK activation on TNF-alpha post-transcriptional expression and TTP function
Zeldich et al., J Cell Physiol 2007 : Although TNF induced the activation of p38 MAPK, JNK, ERK and PI-3K signaling, these pathways were not crucial for EMD protection of hGFs
Defer et al., J Biol Chem 2007 (Calcium Signaling...) : Together with cPLA(2) redistribution and AA release, TNFalpha induced a time dependent phosphorylation of ERK , MSK1, PKCzeta, CaMKII, and phospholamban on the threonine 17 residue
Cheon et al., Exp Mol Med 2007 (MAP Kinase Signaling System) : These results indicate that TNF-alpha production by TCDD in differentiated THP-1 macrophages is AhR dependent and involves activation of EGFR and ERK , but not c-Src, JNK, nor p38 MAPK
Plaisance et al., Am J Physiol Endocrinol Metab 2008 : TNF-alpha activated two signaling cascades : 1 ) ERK1/2 and its target eIF4E and 2 ) Akt and its downstream effectors GSK-3, p70 ( S6K ), and 4E-BP1 ... TNF-alpha induced phosphorylation of Akt, and ERK1/2 was inhibited by an antibody against TNF-alpha receptor 1 (TNF-R1) ... PD-98059 pretreatment abolished TNF-alpha induced phosphorylation of ERK1/2 and eIF4E, whereas PS was only partially inhibited
Jin et al., J Cell Biochem 2008 : Tanshinone IIA inhibited TNF-alpha induced ERK and c-jun phosphorylation, but not other MAPKs such as JNK and p38
Rajesh et al., Br J Pharmacol 2008 : TNF-alpha triggered up to approximately 80 % increase ( depending on the method used ) in CB2 receptor mRNA and/or protein expression in HCASMCs, and induced Ras, p38 MAPK, ERK 1/2, SAPK/JNK and Akt activation, while increasing proliferation and migration
Gaultier et al., J Clin Invest 2008 (Chronic Disease...) : In cultures of Schwann cells, astrocytes, and microglia, sLRP-alpha inhibited TNF-alpha induced activation of p38 MAPK and ERK/MAPK
Hurtado et al., Biochem Biophys Res Commun 2008 : TNF-alpha stimulated MMP-9 expression and Erk1/2 activation were both significantly inhibited by LOX-PP. Immunohistochemistry studies carried out with affinity purified anti-LOX-PP antibody showed that LOX-PP epitopes were expressed at elevated levels in vascular lesions of injured arteries
Ziv et al., J Cell Biochem 2008 (Inflammation...) : By using the EGF receptor (EGFR) tyrosine kinase inhibitor, AG1487 and the Src family inhibitor, PP-1, we established that TNF activated ERK in an EGFR and Src dependent and an EGFR and Src independent modes
Lagoumintzis et al., Scand J Immunol 2008 (Pseudomonas Infections) : TNF-alpha levels were significantly reduced by ERK1/2 inhibitor ( PD98059 ), or p38 inhibitor ( SB203580 )
Yamashita et al., J Endocrinol 2008 (MAP Kinase Signaling System) : Simvastatin potently suppressed TNF-alpha induced phosphorylation of ERK1/2 and SAPK/JNK by inhibiting TNF-alpha induced membrane localization of Ras and RhoA
Yan et al., Inflammation 2008 : Furthermore, the TNF-alpha induced decrease in the phosphorylation of ERK1/2 was abolished by overexpression of SOCS-1
Nizamutdinova et al., Int Immunopharmacol 2008 : All three compounds failed to block TNF-alpha induced phosphorylation of ERK1/2 , which is involved in regulating ICAM-1 production by TNF-alpha
Ogura et al., Int Immunopharmacol 2008 : ERK and p38 MAP kinase are involved in downregulation of cell surface TNF receptor 1 induced by acetoxycycloheximide
Faurschou et al., Exp Dermatol 2008 : In this work, we demonstrate that in the premalignant keratinocyte cell line HaCaT, TNF-alpha activates Akt, ERK1/2 and p38 ... The specific peptide blocking the activity of the atypical protein kinase C ( aPKC ) species zeta and iota/lambda abrogated the effects of TNF-alpha on Akt and ERK1/2 but increased the activation of p38 ... The TNF-alpha dependent phosphorylation of Akt-ERK1/2 was slightly decreased by NF kappaB inhibition and in the presence of p38 blockers
Kang et al., Int Arch Allergy Immunol 2008 (Anaphylaxis) : TNF-alpha-induces cPLA(2) activation through the pathway involving p38 MAPK and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis
Funakoshi-Tago et al., Biochem Pharmacol 2008 : On the other hand, Celecoxib had no effect on the TNFalpha induced nuclear translocation of c-jun and activation of ERK , JNK, p38 and Akt
Ho et al., Immunobiology 2008 (Inflammation...) : Moreover, p38 MAPK inhibitor was found to abrogate the TNF-alpha induced ERK phosphorylation, suggesting that there was a one-way interaction between p38 MAPK and ERK pathways during the TNF-alpha activation
Itatsu et al., Liver Int 2009 (Cholangiocarcinoma) : These data suggest that TNF-alpha/TNF-R1 interaction leads to the phosphorylation of Erk1/2 and p38MAPK and nuclear translocation of NF-kappaB, which is closely associated with the production and activation of MMP-9 in cultured CC cells of HuCTT-1 and CCKS-1
Navenot et al., Mol Pharmacol 2009 : Activation of GPR54 resulted in the ERK dependent expression of tumor necrosis factor-alpha and FasL in a lymphoid cell line, the latter being the main trigger of apoptosis
Kakiashvili et al., J Biol Chem 2009 : Importantly TNF-alpha enhanced the ERK pathway dependent phosphorylation of Thr-678 of GEF-H1 that was key for activation
Yu et al., Vascul Pharmacol 2009 (MAP Kinase Signaling System) : TNF-alpha stimulated the phosphorylation levels of p38 MAPK, JNK, ERK1/2 and Akt in vascular endothelial cells
Kurada et al., J Biol Chem 2009 (Neoplasms) : We investigated the physiological role of endogenous MAPK activating death domain containing protein ( MADD ), a splice variant of the IG20 gene, that can interact with TNFR1 in tumor necrosis factor-alpha (TNFalpha) induced activation of NF-kappaB, MAPK, ERK1/2 , JNK, and p38
Wang et al., FASEB J 2009 (MAP Kinase Signaling System) : In the present study, we demonstrate that CGRP is involved in morphine tolerance by differentially regulating the ERK dependent up-regulation of IL-1beta, TNF-alpha , and microsomal prostaglandin E synthase-1 ( mPGES-1 ) in astrocytes and p38 dependent up-regulation of IL-6 in microglia in the rat spinal cord
Fu et al., Wound Repair Regen 2009 (Disease Models, Animal...) : TNF-alpha at 50 microg/L increased the expression of phospho-ERK and phospho-p38, and SB203580, but not PD98059, could suppress the chemotaxis effect and up-regulation of ICAM-1 induced by TNF-alpha in MSCs ( p < 0.05 )
Wang et al., Surgery 2009 : TNF-alpha and/or TGF-alpha stimulation increased phospho-MEK and phospho-ERK in cells transfected with TNFR1 siRNA
Bruun et al., Mol Cell Endocrinol 2009 : SOCS-3 inhibited TNFalpha induced phosphorylation of the mitogen activated protein kinases ERK1/2 , p38 and JNK in INSr3 # 2 cells and in primary rat islets
Cuong et al., Life Sci 2009 (Inflammation...) : Pre-treatment with C-K significantly inhibited zymosan mediated secretion of tumor necrosis factor-alpha , interleukin (IL)-6, and IL-12 p40, and the activation of ERK1/2 and p38
Ramana et al., Mol Immunol 2009 (Lung Diseases) : We further demonstrate that Egr-1 induction is triggered by TNF-alpha dependent ERK activation, and inhibition of this pathway ablates Egr-1 expression
Liu et al., Proc Natl Acad Sci U S A 2009 : Neither JNK1 activation by IL-1beta or UV nor TNF-alpha induced activation of p38, ERK , or IkappaB kinase complex is affected by the loss of Miz1
Xing et al., J Gen Virol 2010 (Influenza in Birds) : Moreover, ERK alone suppressed TNF-alpha and FasL and inhibited TNF-family mediated extrinsic apoptosis in H9N2 infected chicken macrophages
Ichikawa et al., Biochem Biophys Res Commun 2010 (Vasculitis) : In rat adult VSMCs, adenoviral over-expression of UCH-L1 inhibited TNFalpha induced activation of ERK and DNA synthesis
Lowin et al., Arthritis Rheum 2009 : In addition, cortisol increased the adhesion of SFs to fibronectin and inhibited ERK signaling upon integrin activation or upon stimulation with tumor necrosis factor
Watford et al., J Immunol 2010 (Pneumonia) : The protein kinase encoded by the Tpl2 proto-oncogene regulates ERK activation and cytokine gene expression in macrophages in response to LPS and TNF-alpha
Cho et al., J Cell Physiol 2010 (Calcinosis) : TNF-alpha activated ERK and increased NF-kappaB promoter activity
Ratchford et al., J Biol Chem 2010 : The EGFR dependent stimulation of UTP induced ERK1/2 phosphorylation in HSG cells is inhibited by the adamalysin inhibitor tumor necrosis factor-alpha protease inhibitor or by small interfering RNA that selectively silences ADAM10 and ADAM17 expression, suggesting that ADAM metalloproteases are required for P2Y(2)R mediated activation of the EGFR
Hui et al., Anat Rec (Hoboken) 2010 : In addition, ACSO also inhibited TNF-alpha induced phosphorylation of JNK, ERK1/2 and IkappaB, but not p38
Zha et al., PloS one 2010 : Berberine significantly inhibited HIV PI-induced TNF-alpha and IL-6 expression by modulating ER stress signaling pathways and subsequent ERK activation, in turn preventing the accumulation of the RNA binding protein HuR in cytosol and inhibiting the binding of HuR to the 3'-UTRs of TNF-alpha and IL-6 in macrophages
Nishiumi et al., Toxicological sciences : an official journal of the Society of Toxicology 2010 (Insulin Resistance) : Taken together, TCDD stimulates expression and secretion of TNF-alpha in adipocytes through activation of AhR, ERK1/2 , and JNK, and the secreted TNF-alpha causes the downregulation of IRbeta, IRS1, and GLUT4 through TNFR1, resulting in insulin resistance
Zhang et al., Can J Physiol Pharmacol 2010 (Calcium Signaling...) : Interestingly, endothelial nitric oxide synthase (eNOS) promotes TNF-alpha expression by enhancing p38 MAPK activation, whereas neuronal NOS (nNOS) inhibits TNF-alpha production by reducing Ca2+ dependent ERK1/2 activity
Xuan et al., Cell Physiol Biochem 2010 : Both LPS and GA stimulated the production of IL-6, IL-10, IL12p70 and TNFalpha in a p38- and/or ERK dependent manner
Rastogi et al., Am J Respir Crit Care Med 2011 (Sarcoidosis, Pulmonary) : Inhibition of p38, but not ERK , attenuated production of both IL12/IL23p40 and TNF-a
Leonardi et al., Clin Exp Allergy 2011 (Conjunctivitis, Allergic) : In addition, histamine, IL-4 and TNF-a increased JNK and ERK1/2 expression
Ibrahim et al., Molecular vision 2010 (Diabetes Mellitus, Experimental...) : Genistein represses the release of TNF-a and significantly inhibits ERK and P38 phosphorylation in activated microglial cells by acting as a tyrosine kinase inhibitor
Park et al., Int J Mol Med 2011 : We found that overexpression of the GM3 synthase gene inhibited DNA synthesis and ERK1/2 activity induced by TNF-a in VSMC, whereas the basal levels of DNA synthesis and ERK1/2 activity remained unchanged
Basuroy et al., Am J Physiol Cell Physiol 2011 : The ability of CO to inhibit TNF-a induced ERK1/2 and p38 MAPK activities in an Akt dependent manner appears to be the key element in ROS dependent survival of endothelial cells during TNF-a mediated brain inflammatory disease
Clark et al., Microcirculation 2011 : MEK5 is activated by shear stress, activates ERK5 and induces KLF4 to modulate TNF responses in human dermal microvascular endothelial cells
Wang et al., Inflamm Res 2011 : TNF-a induced phosphorylation of ERK1/2 and JNK, and TNF-a induced IL-6 expression and release were inhibited by selective ERK1/2 and JNK blockers
Kakiashvili et al., J Biol Chem 2011 (MAP Kinase Signaling System) : Surprisingly, TNF-a induced ERK and RhoA stimulation in tubular cells were prevented by epidermal growth factor receptor (EGFR) inhibition or silencing
Cao et al., Acta Diabetol 2013 : TNF-a ( 10 ng/ml ) increased ERK1/2 levels 1.76 ± 0.23-fold ( P < 0.01 ) after 25 mmol/l glucose pretreatment, but added glucose did not enhance ERK1/2 activation when given subsequent to TNF-a treatment
Chen et al., Neurochem Int 2011 : Pharmacological studies revealed that the integrity of lipid raft and the activation of Src, Ras, Raf, ERK , and NF-?B all contributed to JEV induced TNF-a and IL-1ß expression
Wang et al., J Cell Mol Med 2012 (Carcinoma, Hepatocellular...) : Tumour necrosis factor-a (TNF-a) significantly induced phosphorylation of p38 MAPK, ERK , Akt and production of IL-8 from HCC cells, which were prevented by SB203580 ( p38 MAPK inhibitor ), PD98059 ( ERK inhibitor ), LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor )
Ahn et al., Inflammation 2012 (Arthritis, Rheumatoid) : TNF-a induced ERK and NF-?B activation was suppressed in FLS with RKIP overexpression
Uriarte et al., J Immunol 2011 : Pretreatment with TAT-SNAP-23 inhibited the increase in plasma membrane expression of gp91(phox) in TNF-a primed neutrophils, whereas TNF-a activation of ERK1/2 and p38 MAPK was not affected
Kim et al., J Pharmacol Exp Ther 2011 : Furthermore, luteolin inhibited TNF-a induced phosphorylation of mitogen activated protein kinase/extracellular signal regulated kinase ( ERK ) kinase 1/ERK/p90 ( RSK ), mitogen activated protein kinase kinase 4/c-Jun N-terminal kinase/c-Jun, and Akt/p70 ( S6K )
Zhang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2011 : Pretreatment of PD98059 or U0126 inhibited TNF induced IL-6 release and ERK phosphorylation in P815 cells ( P < 0.05 ), whereas pretreatment of SB203580 or AG490 hardly affect IL-6 release, with little effect on phosphorylation of p38 and STAT3 respectively
Hernandez et al., Eur J Pharmacol 2011 (Leprosy) : The drug also reduced M. leprae induced TNF-a production and inhibited p38 and ERK1/2 activation
Kim et al., Immune network 2011 : We further demonstrated that JNK activation was required for TAT-CD137Lct induced production of TNF-a, while activation of Erk and p38 MAPK were involved in IL-6 and TNF-a production
Montecucco et al., Eur Heart J 2012 (Carotid Stenosis...) : This effect was associated with the reduction in TNF-a induced ERK1/2 phosphorylation in human neutrophils
Yan et al., J Biol Chem 2012 (Inflammation...) : Moreover, both ERK1/2 and p38 MAPK are involved in C/EBP induction and TNF-a , MIP-2, and MIP-1a production induced by IgG IC
Kim et al., Vascul Pharmacol 2012 (Atherosclerosis...) : Sulforaphane also suppressed TNF-a induced production of intracellular reactive oxygen species ( ROS ) and activation of p38, ERK and JNK
Zhang et al., Cardiovasc Res 2012 (Endotoxemia...) : MKP1 attenuates ERK1/2 and p38 activation, inhibits myocardial TNF-a expression, and improves cardiac function in endotoxemia
Liu et al., Mol Biol Rep 2012 : Blocking Erk or Akt by pharmacological agent reduced TNF-a or NO production in MMD overexpressing macrophages, respectively
He et al., PloS one 2012 (Inflammation...) : Further studies show that these antagonistic actions occur via mechanisms involving GILZ inhibition of TNF-a induced ERK MAP kinase activation and protein degradation
Wang et al., Invest Ophthalmol Vis Sci 2012 : BBR inhibited the expression of IL-6, IL-8, and MCP-1 remarkably at both protein and mRNA levels and down-regulated the phosphorylation of p38, ERK1/2 , and JNK upon stimulation with TNF-a
Yang et al., Mol Cell Biol 2012 : The Nfkb1 ( SSAA ) mutation prevented the agonist induced release of TPL-2 from its inhibitor p105, which blocked activation of ERK by lipopolysaccharide (LPS), tumor necrosis factor (TNF) , CpG, tripalmitoyl-Cys-Ser-Lys ( Pam ( 3 ) CSK ), poly ( I · C ), flagellin, and R848
Kim et al., Cell Physiol Biochem 2012 (MAP Kinase Signaling System) : The downregulation of IRAK1 or TRADD inhibited TNF-a induced ERK and JNK activation, and hBMSCs proliferation
Kwon et al., J Cell Sci 2012 : We also observed that in THP-1 and PBMCs, AIMP1 induced TNF-a secretion, mediated by CD23, involved activation of ERK1/2
Jia et al., J Cell Physiol 2013 (MAP Kinase Signaling System...) : Blocking FPR2 using the specific antagonist WRW4 mimicked the effects of AnxA1 silencing on TNF induced proliferation, IL-6, ERK , and NF-?B activation
Zhong et al., Biochem Biophys Res Commun 2012 (MAP Kinase Signaling System) : Omentin pretreatment significantly inhibited TNF-a induced ERK activity and ERK phosphorylation in HUVECs
Jijon et al., Mediators Inflamm 2012 : TNF-a treatment of IECs resulted in an association between EGFR and HER2 and inhibition of HER2 using a specific inhibitor AG879 in combination with AG1478 suppressed TNF-a dependent ERK phosphorylation and IL-8 release
Berasain et al., Dig Dis 2012 (Carcinoma, Hepatocellular...) : AR was necessary for TNF-a activation of ERK1/2 and Akt signaling in hepatocytes
Xu et al., Pharmacol Res 2013 : Western blot analysis revealed that pilocarpine and physostigmine enhanced the TNF-a induced phosphorylation of ERK1/2 and p38 MAPK and the degradation of I?Ba
Norsted Gregory et al., J Neurosci Res 2013 : Furthermore, we show that pentoxifylline and propentofylline also inhibit JNK and p38, but not ERK , activation induced by TNF
Nasimian et al., Inflamm Res 2013 : NF-kB, JNK, p38 and ERK specific inhibitors significantly reduced the production of TNF-a and IL-6 in macrophages stimulated with palmitate and also PTP1B knockdown cells
Jeong et al., Food Chem Toxicol 2013 : In addition, PA inhibited LPS- or TNF-a stimulated ERK1/2 activation by decreasing phosphorylation of ERK1/2
Kempuraj et al., J Neuroimmune Pharmacol 2013 : IL-33 induces CCL2, TNF-a and nitric oxide release through phosphorylation of ERK in mouse astrocytes
Wu et al., Biochem Pharmacol 2013 (Inflammation) : Taken together, statins, via ERK5 activation, suppress TNF stimulated Rac-1 activation, ROS generation, NF-?B activation and VCAM-1 and ICAM-1 expression in human ECs, which provides a novel explanation for the pleiotropic effects of statins that benefit the cardiovascular system
Lee et al., Food Chem Toxicol 2013 : Further studies revealed that PL suppressed the production of tumor necrosis factor-a (TNF-a) or Interleukin (IL)-6 and activation of nuclear factor-?B ( NF-?B ) or extracellular regulated kinases (ERK) 1/2 by LPS
Hu et al., Cell Signal 2013 (Ischemia) : This inhibitory effect of AGGF1 was further proved through blocking the phosphorylation of ERK induced by TNF-a
Lee et al., Int Immunopharmacol 2013 (Dermatitis, Atopic...) : QGR, dexamethasone, cyclosporine A, Bay 11-7085 ( an inhibitor of NF-?B activation ) and cell signaling ERK inhibitor attenuated the TNF-a induced formation of inflammatory mediators and activation of the NF-?B and ERK
Cheng et al., J Immunol 2013 (MAP Kinase Signaling System) : GILZ overexpression also inhibited TNF induced activation of p38, ERK , and JNK MAPKs, as well as increased expression of the MAPK inhibitory phosphatase, MKP-1
Tsai et al., PloS one 2013 : Bla g 2 can stimulate up-regulation of inflammatory cytokines including TNF-alpha and IL-6 and activation of nuclear factor kappa B ( NF-kB/p65 ), p38 mitogen activated protein kinase ( p38 ), ERK , and JNK in cultured fibrocytes ... This increased secretion of TNF-alpha and IL-6 and activation of NF-kB, ERK , and JNK was significantly inhibited by the addition of either mannan or mannose
Wu et al., Cell Res 2013 : Mlkl-deficient MEFs and macrophages were indistinguishable from wild-type cells in their ability to activate NF-?B, ERK , JNK, and p38 in response to TNF and lipopolysaccharides (LPS), respectively
Hosokawa et al., Cell Physiol Biochem 2013 : Western blot analysis revealed that EGCG treatment prevented IL-1ß/IL-4 or TNF-a/IL-4 induced ERK and JNK activation in HGFs. Conclusions : These data provide that CCL11 production in HGFs could be associated with Th2 cells infiltration in periodontal lesions
Dionne et al., Biochem Biophys Res Commun 1998 : TNF-alpha increased ERK1 and ERK2 MAPK phosphorylation
Trotta et al., J Immunol 1998 : We have reported that ERK2 phosphorylation and activation follows engagement of the low affinity receptor for the Fc portion of IgG ( CD16 ) on NK cells, and is necessary for CD16 induced TNF-alpha mRNA expression
Suzuki et al., Blood 1999 : MEK inhibitor ( PD98059 ) reduced tyrosine phosphorylation of ERK , but not p38 MAPK, induced by G-CSF, GM-CSF, or TNF
Goebeler et al., Blood 1999 : We show that tumor necrosis factor-alpha (TNF-alpha) , a potent inflammatory activator of endothelium, leads to activation of MAP kinases ERK , p38, and JNK in human umbilical vein endothelial cells ( HUVEC )